MedPath

Indinavir

Generic Name
Indinavir
Brand Names
Crixivan
Drug Type
Small Molecule
Chemical Formula
C36H47N5O4
CAS Number
150378-17-9
Unique Ingredient Identifier
9MG78X43ZT
Background

A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]

Indication

Indinavir is an antiretroviral drug for the treatment of HIV infection.

Associated Conditions
Human Immunodeficiency Virus Type 1 (HIV-1) Infection
Associated Therapies
-

Safety and Effectiveness of an Anti-HIV Drug Combination With and Without Hydroxyurea in Patients With Early HIV Infection

Phase 2
Withdrawn
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-11-01
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Registration Number
NCT00006339

Drug Interactions of Amprenavir and Efavirenz, in Combination With a Second Protease Inhibitor, in HIV-Negative Volunteers

Not Applicable
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-11-01
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
90
Registration Number
NCT00005762
Locations
🇺🇸

Stanford CRS, Palo Alto, California, United States

🇺🇸

University of Colorado Hospital CRS, Aurora, Colorado, United States

🇺🇸

Indiana Univ. School of Medicine, Infectious Disease Research Clinic, Indianapolis, Indiana, United States

and more 5 locations

A Phase II Study of Intermittent Recombinant Human Interleukin-2 (rhIL-2) by Intravenous or Subcutaneous Administration in Subjects With HIV Infection on Highly Active Antiretroviral Therapy (HAART) Compared to HAART Alone

Phase 2
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2012-05-21
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
200
Registration Number
NCT00000870
Locations
🇺🇸

The Ohio State Univ. AIDS CRS, Columbus, Ohio, United States

🇺🇸

Beth Israel Deaconess - East Campus A0102 CRS, Boston, Massachusetts, United States

🇺🇸

Case CRS, Cleveland, Ohio, United States

and more 17 locations

A Study of Indinavir Sulfate Plus Zidovudine (AZT) Plus Lamivudine in HIV-Infected Patients Who Have Taken AZT for Six or More Months

Phase 3
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
1750
Registration Number
NCT00000841
Locations
🇺🇸

Univ of Southern California / LA County USC Med Ctr, Los Angeles, California, United States

🇺🇸

UCLA CARE Ctr, Los Angeles, California, United States

🇺🇸

Emory Univ, Atlanta, Georgia, United States

and more 84 locations

A Randomized Trial of the Efficacy and Safety of a Strategy of Starting With Nelfinavir Versus Ritonavir Added to Background Antiretroviral (AR) Nucleoside Therapy in HIV-Infected Individuals With CD4+ Cell Counts Less Than or Equal to 200/mm3

Not Applicable
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-10-29
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
1300
Registration Number
NCT00000859
Locations
🇺🇸

AIDS Research Consortium of Atlanta, Atlanta, Georgia, United States

🇺🇸

AIDS Research Alliance - Chicago, Chicago, Illinois, United States

🇺🇸

Baltimore TRIALS, Baltimore, Maryland, United States

and more 40 locations

The Addition of Indinavir to Anti-HIV Treatment in HIV-Infected Patients

Not Applicable
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-10-28
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
1900
Registration Number
NCT00000861
Locations
🇺🇸

Southern New Jersey AIDS Cln Trials / Dept of Med, Camden, New Jersey, United States

🇺🇸

Veterans Administration Med Ctr / Regional AIDS Program, Washington, District of Columbia, United States

🇺🇸

North Jersey Community Research Initiative, Newark, New Jersey, United States

and more 11 locations

A Study of Three Anti-HIV Drug Combinations in Patients Who Have Taken Amprenavir

Phase 2
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-11-04
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
94
Registration Number
NCT00001095
Locations
🇺🇸

St Louis Regional Hosp / St Louis Regional Med Ctr, Saint Louis, Missouri, United States

🇺🇸

Univ of North Carolina, Chapel Hill, North Carolina, United States

🇺🇸

Univ of Southern California / LA County USC Med Ctr, Los Angeles, California, United States

and more 9 locations

Ritonavir and Indinavir in Children Failing Other Anti-HIV Treatment

Phase 1
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-11-01
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
29
Registration Number
NCT00012519
Locations
🇺🇸

Howard Univ. Washington DC NICHD CRS, Washington, District of Columbia, United States

🇺🇸

Univ. of Florida Jacksonville NICHD CRS, Jacksonville, Florida, United States

🇺🇸

Metropolitan Hosp. Ctr., New York, New York, United States

and more 9 locations

Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children

Phase 1
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2021-10-28
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
24
Registration Number
NCT00000901
Locations
🇺🇸

UCSD Med Ctr / Pediatrics / Clinical Sciences, La Jolla, California, United States

🇺🇸

Univ of Florida Health Science Ctr / Pediatrics, Jacksonville, Florida, United States

🇺🇸

Incarnation Children's Ctr / Columbia Presbyterian Med Ctr, New York, New York, United States

and more 16 locations

Effects on the Immune System of Anti-HIV Drugs in Patients Recently Infected With HIV

Not Applicable
Completed
Conditions
HIV Infections
First Posted Date
2001-08-31
Last Posted Date
2011-03-02
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
288
Registration Number
NCT00001119
Locations
🇺🇸

Seattle HIVNET, Seattle, Washington, United States

🇺🇸

Univ of Washington, Seattle, Washington, United States

🇺🇸

Univ of Minnesota, Minneapolis, Minnesota, United States

and more 9 locations
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