Lifitegrast
- Generic Name
- Lifitegrast
- Brand Names
- Xiidra
- Drug Type
- Small Molecule
- Chemical Formula
- C29H24Cl2N2O7S
- CAS Number
- 1025967-78-5
- Unique Ingredient Identifier
- 038E5L962W
- Background
Lifitegrast is a FDA approved drug for the treatment of keratoconjunctivitis sicca (dry eye syndrome). It is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design process. The ophthalmic solution was approved in July, 2016 under the trade name Xiidra. It has shown ...
- Indication
适用于治疗干眼病（DED）的症状和体征。
- Associated Conditions
- Dry Eye Syndrome (DES)
- Associated Therapies
- -
Examining the Clinical Characteristics, Treatment Patterns, Real-world Effectiveness, and Healthcare Resource Utilization of Patients With Dry Eye Disease
- First Posted Date
- 2023-05-15
- Last Posted Date
- 2023-09-01
- Lead Sponsor
- Novartis Pharmaceuticals
- Registration Number
- NCT05857748
The Effect of Xiidra on Comfort and Dryness in Symptomatic Contact Lens Wearers
- First Posted Date
- 2020-03-05
- Last Posted Date
- 2024-06-27
- Lead Sponsor
- University of Waterloo
- Target Recruit Count
- 45
- Registration Number
- NCT04297618
- Locations
- 🇨🇦
Centre for Ocular Research & Education, Waterloo, Ontario, Canada
Clinical Efficacy of Two Topical Dry Eye Drops for Central Corneal Stain Clearing Over 90 Days
- Conditions
- Interventions
- First Posted Date
- 2019-11-21
- Last Posted Date
- 2022-10-20
- Lead Sponsor
- Toyos Clinic
- Target Recruit Count
- 100
- Registration Number
- NCT04172961
- Locations
- 🇺🇸
Toyos Clinic, Nashville, Tennessee, United States
A Study of the Drugs AGN-242428 and AGN-231868 in Participants With Dry Eye Disease
- Conditions
- Interventions
- First Posted Date
- 2019-07-24
- Last Posted Date
- 2023-03-20
- Lead Sponsor
- Allergan
- Target Recruit Count
- 292
- Registration Number
- NCT04030962
- Locations
- 🇺🇸
Piedmont Eye Center /ID# 232698, Lynchburg, Virginia, United States
🇺🇸Cornea and Cataract Consultants of Arizona /ID# 232769, Phoenix, Arizona, United States
🇺🇸Total Eye Care, PA /ID# 232657, Memphis, Tennessee, United States
The Effect Of Lifitegrast On Refractive Accuracy And Symptoms In Dry Eye Patients Undergoing Cataract Surgery
- First Posted Date
- 2019-03-07
- Last Posted Date
- 2020-03-19
- Lead Sponsor
- MDbackline, LLC
- Target Recruit Count
- 103
- Registration Number
- NCT03866629
- Locations
- 🇺🇸
Harvard Eye Associates, Laguna Hills, California, United States
Lifitegrast 5% Ophthalmic Solution and Contact Lens Dryness
- Conditions
- Interventions
- First Posted Date
- 2018-09-27
- Last Posted Date
- 2018-09-28
- Lead Sponsor
- EV Clinical Trials
- Target Recruit Count
- 21
- Registration Number
- NCT03686878
- Locations
- 🇺🇸
Eye & Vision, Richardson, Texas, United States
Effect of Lifitegrast on Dry Eye Disease Signs and Symptoms
- First Posted Date
- 2018-03-01
- Last Posted Date
- 2018-03-19
- Lead Sponsor
- Lifelong Vision Foundation
- Target Recruit Count
- 30
- Registration Number
- NCT03451396
- Locations
- 🇺🇸
Lifelong Vision Foundation, Chesterfield, Missouri, United States
Use of 5.0% Lifitegrast Ophthalmic Solution for the Treatment of Dry Eye Disease in Contact Lens Wearers
- First Posted Date
- 2018-02-13
- Last Posted Date
- 2018-10-25
- Lead Sponsor
- University of Alabama at Birmingham
- Registration Number
- NCT03431272
- Locations
- 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease
- Conditions
- Interventions
- First Posted Date
- 2018-01-23
- Last Posted Date
- 2019-05-17
- Lead Sponsor
- University of Alabama at Birmingham
- Registration Number
- NCT03408015
A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3)
- First Posted Date
- 2014-11-06
- Last Posted Date
- 2021-06-11
- Lead Sponsor
- Shire
- Target Recruit Count
- 711
- Registration Number
- NCT02284516
- Locations
- 🇺🇸
Chicago Cornea Consultants, Ltd., Hoffman Estates, Illinois, United States
🇺🇸Jackson Eye, SC, Lake Villa, Illinois, United States
🇺🇸Lifelong Vision Foundation, Chesterfield, Missouri, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.