Carvedilol
- Generic Name
- Carvedilol
- Brand Names
- Coreg
- Drug Type
- Small Molecule
- Chemical Formula
- C24H26N2O4
- CAS Number
- 72956-09-3
- Unique Ingredient Identifier
- 0K47UL67F2
- Background
Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. It is currently used to treat heart failure, left ventricular dysfunction, and hypertension. The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension.
Carvedilol was granted FDA approval on 14 September 1995.
- Indication
Carvedilol is indicated to treat mild to severe heart failure, left ventricular dysfunction after myocardial infarction with ventricular ejection fraction ≤40%, or hypertension.
- Associated Conditions
- Atrial Fibrillation, Chronic Stable Angina Pectoris, Hypertension, LVEF ≤40% Left ventricular dysfunction, NYHA Class I or II heart failure, Chronic heart failure with reduced ejection fraction (NYHA Class III), Chronic heart failure with reduced ejection fraction (NYHA Class IV)
- Associated Therapies
- -
Comparison of Effect of cARvedilol Compared To bISoprolol on cenTral Pulse Pressure in Hypertension (ARTIST) Study
- First Posted Date
- 2010-11-19
- Last Posted Date
- 2012-07-19
- Lead Sponsor
- Yoshio Matsui
- Target Recruit Count
- 200
- Registration Number
- NCT01243827
- Locations
- 🇯🇵
Iwakuni City Medical Center, Yamaguchi, Japan
Carvedilol Versus Placebo for Treatment in Post Traumatic Stress Disorder (PTSD)
- First Posted Date
- 2010-10-15
- Last Posted Date
- 2011-06-08
- Lead Sponsor
- Columbia Northwest Pharmaceuticals
- Target Recruit Count
- 80
- Registration Number
- NCT01221792
- Locations
- 🇺🇸
Lake Charles Clinical Trials, Lake Charles, Louisiana, United States
🇺🇸Artemis Institute for Clinical Research, San Diego, California, United States
🇺🇸Northwest Clinical Research Center, Bellevue, Washington, United States
Carvedilol for Pre-primary Prophylaxis of Esophageal Varices in Cirrhosis
- First Posted Date
- 2010-09-30
- Last Posted Date
- 2019-11-05
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 132
- Registration Number
- NCT01212250
- Locations
- 🇮🇳
Institute of Liver & Biliary Sciences (ILBS), New Delhi, Delhi, India
Early Primary Prophylaxis of Esophageal Varices
- First Posted Date
- 2010-09-08
- Last Posted Date
- 2016-06-15
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 140
- Registration Number
- NCT01196507
- Locations
- 🇮🇳
Institute of Liver & Biliary Sciences (ILBS), New Delhi, Delhi, India
Heart Rate Reduction in Heart Failure
- First Posted Date
- 2010-08-10
- Last Posted Date
- 2014-09-30
- Lead Sponsor
- IRCCS San Raffaele
- Target Recruit Count
- 121
- Registration Number
- NCT01178528
- Locations
- 🇮🇹
Centre for Clinical and Basic Research - IRCCS San Raffaele, Roma, Italy
🇮🇹IRCCS San Raffaele, Roma, Italy
Carvedilol Post-intervention Long-term Administration in Large-scale Trial
- First Posted Date
- 2010-07-02
- Last Posted Date
- 2017-06-27
- Lead Sponsor
- Takeshi Morimoto
- Target Recruit Count
- 801
- Registration Number
- NCT01155635
- Locations
- 🇯🇵
Division of Cardiology, Kyoto University Hospital, Kyoto, Japan
A Trial of Nadolol Plus Isosorbide Mononitrate Versus Carvedilol for the Prevention of Variceal Rebleeding
- First Posted Date
- 2010-04-14
- Last Posted Date
- 2010-10-26
- Lead Sponsor
- E-DA Hospital
- Target Recruit Count
- 121
- Registration Number
- NCT01103154
RCT of Carvedilol Versus Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage
- Conditions
- Portal Hypertension
- Interventions
- Drug: CarvedilolProcedure: Esophageal variceal band ligation
- First Posted Date
- 2010-02-18
- Last Posted Date
- 2010-02-18
- Lead Sponsor
- Aga Khan University
- Target Recruit Count
- 148
- Registration Number
- NCT01070641
- Locations
- 🇵🇰
Aga Khan University Hospital, Karachi, Sindh, Pakistan
Carvedilol 25 mg Film-coated Tablets, Bioequivalence Study of Dr. Reddys Under Fasting Conditions
- First Posted Date
- 2010-02-08
- Last Posted Date
- 2010-02-08
- Lead Sponsor
- Dr. Reddy's Laboratories Limited
- Target Recruit Count
- 36
- Registration Number
- NCT01064154
Carvedilol 25 mg Film-coated Tablets, Bioequivalence Study of Dr. Reddys Under Fed Conditions
- First Posted Date
- 2010-02-08
- Last Posted Date
- 2010-02-08
- Lead Sponsor
- Dr. Reddy's Laboratories Limited
- Target Recruit Count
- 24
- Registration Number
- NCT01064180
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.