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Zinc chloride is a medication used to treat zinc deficiencies and associated symptoms and also in total parenteral nutrition.
Zinc chloride is a medication used to treat zinc deficiencies and associated symptoms and also in total parenteral nutrition.
Zinc performs catalytic, structural, and regulatory roles in the body. Zinc is a component of approximately 3000 human proteins. Zinc is cytoprotective against reactive oxygen species mediated apoptosis through the action of metallothioneins. In a promyelocytic leukemia cell line, zinc enhances the up-regulation of A20 mRNA, which, via the TRAF pathway, decreases NF-kappaB activation, leading to decreased gene expression and generation of TNF-α, IL-1β, and IL-8 . In patients with diarrhea, zinc restores mucosal barrier integrity, restores enterocyte brush-border enzyme activity, promotes the production of antibodies, and promotes the production of circulating lymphocytes against intestinal pathogens. Zinc also directly affects ion channels as a potassium channel blocker of cAMP-mediated chlorine secretion. Zinc deficiency decreases thymulin, inhibiting T-helper cell maturation and decreased Th-1 cytokines like IL-2. Decreased IL-2 decreases the activity of NK cells and CD8+ T cells. Zinc deficiency also leads to the generation of CD4+ T cells, decreased NF-κB activation, decreased phosphorylation of IκB, and decreased binding of NF-κB to DNA.
Zinc chloride injections are indicated for use total parenteral nutrition to maintain zinc serum levels and prevent deficiency syndromes.
每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。
