Vilazodone

Generic Name: Vilazodone

Brand Names: Viibryd

Drug Type: Small Molecule

Chemical Formula: C_₂₆H_₂₇N_₅O_₂

CAS Number: 163521-12-8

Unique Ingredient Identifier: S239O2OOV3

Background: Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors. Vilazodone may also be associated with less sexual dysfunction and weight gain. Vilazodone was given FDA approval on January 21, 2011.

Indication: 用于治疗成人重度抑郁症（MDD）。

Associated Conditions: Major Depressive Disorder (MDD)

Associated Therapies: -

Clinical Trials

Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies

Terminated

Conditions: Bipolar Disorder

First Posted Date: 2016-09-08

Last Posted Date: 2024-03-12

Lead Sponsor: University of New Mexico

Target Recruit Count: 1037352

Registration Number: NCT02893371

Locations: 🇺🇸
Christophe G Lambert, Albuquerque, New Mexico, United States

A Study of Vilazodone in Pediatric Patients With Major Depressive Disorder

Phase 3

Completed

Conditions: Major Depressive Disorder

Interventions: Drug: Vilazodone

First Posted Date: 2015-05-06

Last Posted Date: 2019-09-11

Lead Sponsor: Forest Laboratories

Target Recruit Count: 330

Registration Number: NCT02436239

Locations: 🇺🇸
ATP Clinical Research, Costa Mesa, California, United States
🇺🇸
Psychiatric Associates, Overland Park, Kansas, United States
🇺🇸
Pharmsite Research Inc., Baltimore, Maryland, United States

and more 52 locations

Safety and Efficacy of Vilazodone in Pediatric Patients With Major Depressive Disorder (VLZ-MD-22)

Phase 3

Completed

Conditions: Major Depressive Disorder

Interventions: Drug: Vilazodone
Drug: Placebo
Drug: Fluoxetine

First Posted Date: 2015-02-26

Last Posted Date: 2019-10-01

Lead Sponsor: Forest Laboratories

Target Recruit Count: 473

Registration Number: NCT02372799

Locations: 🇺🇸
Harmonex Neuroscience Research, Dothan, Alabama, United States
🇺🇸
Woodland International Research Group, INC, Little Rock, Arkansas, United States
🇺🇸
ATP Clinical Research, Costa Mesa, California, United States

and more 56 locations

The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressives

Phase 4

Withdrawn

Conditions: Comorbidity
Major Depressive Disorder
Anxiety

Interventions: Drug: Citalopram
Drug: Vilazodone

First Posted Date: 2014-01-06

Last Posted Date: 2016-11-08

Lead Sponsor: Massachusetts General Hospital

Registration Number: NCT02028026

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

Switching From Generic Selective Serotonin Reuptake Inhibitors (SSRIs) and Selective Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) to Three Different Dose Initiation Strategies With Vilazodone

Phase 3

Completed

Conditions: Major Depressive Disorder (MDD)

Interventions: Drug: Vilazodone

First Posted Date: 2013-12-19

Last Posted Date: 2015-04-16

Lead Sponsor: Duke University

Target Recruit Count: 70

Registration Number: NCT02015546

Locations: 🇺🇸
Duke University Medical Center / Civitan Building, Durham, North Carolina, United States

Vilazodone for Separation Anxiety Disorder

Phase 4

Completed

Conditions: Separation Anxiety Disorder

Interventions: Drug: Placebo
Drug: Vilazodone

First Posted Date: 2013-12-03

Last Posted Date: 2018-03-07

Lead Sponsor: New York State Psychiatric Institute

Target Recruit Count: 24

Registration Number: NCT01999920

Locations: 🇺🇸
New York State Psychiatric Institute, New York, New York, United States

Safety and Efficacy of Vilazodone in Adolescent Patients With Major Depressive Disorder

Phase 3

Completed

Conditions: Major Depressive Disorder

Interventions: Drug: Placebo
Drug: Vilazodone

First Posted Date: 2013-06-14

Last Posted Date: 2019-12-24

Lead Sponsor: Forest Laboratories

Target Recruit Count: 529

Registration Number: NCT01878292

Locations: 🇺🇸
Forest Investigative Site 054, Baltimore, Maryland, United States
🇺🇸
Forest Investigative Site 034, Oakland Park, Florida, United States
🇺🇸
Forest Investigative Site 030, Roswell, Georgia, United States

and more 49 locations

Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction?

Phase 4

Terminated

Conditions: Sexual Dysfunction
Major Depressive Disorder

Interventions: Drug: Vilazodone
Drug: Sertraline

First Posted Date: 2013-05-17

Last Posted Date: 2016-08-25

Lead Sponsor: Thomas Jefferson University

Target Recruit Count: 4

Registration Number: NCT01856127

Locations: 🇺🇸
University of Pennsylvania, Philadelphia, Pennsylvania, United States
🇺🇸
University of Virginia, Charlottesville, Virginia, United States
🇺🇸
Thomas Jefferson University, Philadelphia, Pennsylvania, United States

Safety, Efficacy and Tolerability of Vilazodone in (GAD) Generalized Anxiety Disorder

Phase 3

Completed

Conditions: Generalized Anxiety Disorder

Interventions: Drug: Placebo
Drug: Vilazodone

First Posted Date: 2013-05-01

Last Posted Date: 2019-12-18

Lead Sponsor: Forest Laboratories

Target Recruit Count: 415

Registration Number: NCT01844115

Locations: 🇺🇸
Forest Investigative Site 023, Birmingham, Alabama, United States
🇺🇸
Forest Investigative Site 013, Phoenix, Arizona, United States
🇺🇸
Forest Investigative Site 001, Costa Mesa, California, United States

and more 33 locations

Vilazodone for Corticosteroid-Induced Memory Impairment

Phase 2

Completed

Conditions: Memory Impairment

Interventions: Drug: Vilazodone
Drug: Placebo
Drug: Hydrocortisone

First Posted Date: 2013-04-10

Last Posted Date: 2019-04-11

Lead Sponsor: University of Texas Southwestern Medical Center

Target Recruit Count: 24

Registration Number: NCT01828515

Locations: 🇺🇸
UT Southwestern Medical Center, Dallas, Texas, United States

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