Azathioprine
- Generic Name
- Azathioprine
- Brand Names
- Azasan, Imuran, Jayempi
- Drug Type
- Small Molecule
- Chemical Formula
- C9H7N7O2S
- CAS Number
- 446-86-6
- Unique Ingredient Identifier
- MRK240IY2L
- Background
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index. Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transp...
- Indication
Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.
- Associated Conditions
- Atopic Dermatitis, Crohn's Disease (CD), Immune Thrombocytopenia (ITP), Kidney Transplant Rejection, Lupus Nephritis, Multiple Sclerosis, Pericarditis, Psoriasis, Rheumatoid Arthritis, Uveitis
- Associated Therapies
- -
Th1, Th2 and Monokine Responses as Risk Factors of Renal Transplant Rejection
- Conditions
- First Posted Date
- 2005-09-08
- Last Posted Date
- 2007-05-10
- Lead Sponsor
- University of Giessen
- Target Recruit Count
- 84
- Registration Number
- NCT00150891
- Locations
- 🇩🇪
Department of Internal Medicine, University of Giessen, Giessen, Germany
Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis
- First Posted Date
- 2005-08-10
- Last Posted Date
- 2018-12-13
- Lead Sponsor
- University Medical Center Groningen
- Target Recruit Count
- 131
- Registration Number
- NCT00128895
- Locations
- 🇳🇱
Erasmus Medical Centre, Rotterdam, Netherlands
🇳🇱VU University Medical Centre, Amsterdam, Netherlands
🇳🇱University Hospital Maastricht, Maastricht, Netherlands
Rituximab for the Treatment of Wegener's Granulomatosis and Microscopic Polyangiitis
- Conditions
- Interventions
- First Posted Date
- 2005-02-25
- Last Posted Date
- 2017-04-21
- Target Recruit Count
- 197
- Registration Number
- NCT00104299
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
🇺🇸University of Alabama, Birmingham, Alabama, United States
🇺🇸Johns Hopkins University, Baltimore, Maryland, United States
Imuran (Azathioprine) Dose-Ranging Study in Crohn's Disease
- First Posted Date
- 2004-12-06
- Last Posted Date
- 2014-02-21
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 31
- Registration Number
- NCT00098111
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
A Randomized, Double-Blind, Three-Arm, Phase 3b Study Comparing the Safety and Efficacy of Interferon Gamma-1b With Azathioprine, and Azathioprine Alone in Patients With IPF Receiving Prednisone
- Conditions
- First Posted Date
- 2003-01-22
- Last Posted Date
- 2007-11-06
- Lead Sponsor
- InterMune
- Registration Number
- NCT00052039
- Locations
- 🇮🇹
Ospedale S. Luigi Gonzaga - Regione, Torino, Orbassano, Italy
Drug Development Updates
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