Proguanil
- Generic Name
- Proguanil
- Brand Names
- Malarone
- Drug Type
- Small Molecule
- Chemical Formula
- C11H16ClN5
- CAS Number
- 500-92-5
- Unique Ingredient Identifier
- S61K3P7B2V
- Background
Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
- Indication
For the causal prevention and suppression of malaria caused by susceptible strains of P. falciparum and other species of Plasmodium found in some geographical areas of the world.
- Associated Conditions
- Malaria caused by Plasmodium falciparum, Acute, uncomplicated Malaria caused by plasmodium falciparum
- Associated Therapies
- -
Atoguanil BA Study
- First Posted Date
- 2021-04-30
- Last Posted Date
- 2022-05-05
- Lead Sponsor
- Medicines for Malaria Venture
- Target Recruit Count
- 16
- Registration Number
- NCT04866602
- Locations
- 🇬🇧
Richmond Pharmacology Limited, London, United Kingdom
Malarone Pharmacokinetics Under Simulated Physiologic Stressors of Deployment
- First Posted Date
- 2019-06-19
- Last Posted Date
- 2021-04-30
- Lead Sponsor
- Walter Reed Army Institute of Research (WRAIR)
- Registration Number
- NCT03991208
- Locations
- 🇺🇸
Uniformed Services University, Bethesda, Maryland, United States
DSM265 Chemoprophylaxis of Plasmodium Falciparum Malaria
- Conditions
- Interventions
- First Posted Date
- 2015-05-21
- Last Posted Date
- 2021-01-13
- Lead Sponsor
- Medicines for Malaria Venture
- Target Recruit Count
- 22
- Registration Number
- NCT02450578
- Locations
- 🇩🇪
Universitätsklinikum Tübingen, Institut für Tropenmedizin, Tübingen, Germany
Impact of CYP2C19*17 on the Pharmacokinetics of Proguanil and Clopidogrel
- First Posted Date
- 2011-10-20
- Last Posted Date
- 2013-07-03
- Lead Sponsor
- University of Southern Denmark
- Target Recruit Count
- 31
- Registration Number
- NCT01456546
- Locations
- 🇩🇰
Clinical Pharmacology, University of Southern Denmark, Odense, Fyn, Denmark
Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine Versus Mefloquine Prophylaxis
- Conditions
- Interventions
- First Posted Date
- 2011-08-25
- Last Posted Date
- 2013-04-29
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 20
- Registration Number
- NCT01422954
- Locations
- 🇳🇱
Leiden University Medical Centre, Leiden, Netherlands
Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell Disease
- Conditions
- Interventions
- First Posted Date
- 2011-03-21
- Last Posted Date
- 2014-03-21
- Lead Sponsor
- London School of Hygiene and Tropical Medicine
- Target Recruit Count
- 270
- Registration Number
- NCT01319448
- Locations
- 🇳🇬
Department of Paediatrics and Child Health, University of Ilorin Teaching Hospital, Ilorin, Kwara, Nigeria
Safety and Efficacy Study of IV Artesunate to Treat Malaria
- First Posted Date
- 2006-03-02
- Last Posted Date
- 2019-10-01
- Target Recruit Count
- 30
- Registration Number
- NCT00298610
- Locations
- 🇰🇪
New Nyanza Provincial Hospital, Kisumu, New Nyanza, Kenya
Drug Development Updates
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