Overview
Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play a role in ensuring that cancer cells do not continue to replicate uncontrollably. Ribociclib was approved by the U.S. FDA in March, 2017 as Kisqali.
Background
Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play a role in ensuring that cancer cells do not continue to replicate uncontrollably. Ribociclib was approved by the U.S. FDA in March, 2017 as Kisqali.
Indication
用于联合芳香酶抑制剂或氟维司群治疗激素受体(HR)阳性、人表皮生长因子受体2(HER2)阴性的晚期或转移性乳腺癌成人患者。
Associated Conditions
- Advanced Breast Cancer
- Metastatic Breast Cancer
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2021/12/10 | N/A | Completed | |||
2021/09/09 | N/A | AVAILABLE | |||
2021/07/16 | Phase 3 | Active, not recruiting | |||
2021/04/28 | Phase 3 | Recruiting | |||
2021/04/21 | N/A | UNKNOWN | Blokhin's Russian Cancer Research Center | ||
2021/03/17 | Phase 1 | Recruiting | |||
2021/03/17 | Not Applicable | Terminated | Peter MacCallum Cancer Centre, Australia | ||
2020/12/08 | Phase 4 | Terminated | |||
2020/10/14 | Phase 1 | Withdrawn | |||
2020/06/04 | Phase 2 | Active, not recruiting |
FDA Drug Approvals
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| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
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HSA Drug Approvals
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NMPA Drug Approvals
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PPB Drug Approvals
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| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
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| No TGA approvals found for this drug. | |||||