Lithium cation
- Generic Name
- Lithium cation
- Drug Type
- Small Molecule
- Chemical Formula
- Li
- CAS Number
- 7439-93-2
- Unique Ingredient Identifier
- 8H8Z5UER66
- Background
Lithium was used during the 19th century to treat gout. Lithium salts such as lithium carbonate (Li2CO3), lithium citrate, and lithium orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression. Lithium can also be used to augment other antidepressant drugs. It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. The active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several critical neuronal enzymes and neurotransmitter receptors.
- Indication
Lithium, in its salt forms, is used as a mood stabilizer and for the treatment of depression and mania. It is most frequently prescribed in the treatment of bipolar disorder.
- Associated Conditions
- Bipolar Disorder (BD), Depression, Depression, Bipolar, Acute Manic episode
Treatment and Outcome of Early Onset Bipolar Disorder
- Conditions
- Bipolar Disorder
- First Posted Date
- 2002-11-13
- Last Posted Date
- 2014-01-22
- Lead Sponsor
- Northwell Health
- Target Recruit Count
- 40
- Registration Number
- NCT00048802
- Locations
- 🇺🇸
The Zucker Hillside Hospital, Long Island Jewish Medical Center, Glen Oaks, New York, United States
Optimizing Electroconvulsive Therapy for Depression
- Conditions
- DepressionDepressive DisorderBipolar Disorder
- Interventions
- Procedure: High dosage electroconvulsive therapyProcedure: Low dosage electroconvulsive therapy
- First Posted Date
- 2002-09-17
- Last Posted Date
- 2013-08-13
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 340
- Registration Number
- NCT00045916
- Locations
- 🇺🇸
Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, United States
🇺🇸New York State Psychiatric Institute at Columbia University, New York, New York, United States
🇺🇸Wake Forest University, Winston-Salem, North Carolina, United States
Relapse Prevention for Bipolar Type-II Disorder
- Conditions
- DepressionBipolar Disorder
- First Posted Date
- 2002-09-05
- Last Posted Date
- 2015-10-06
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 180
- Registration Number
- NCT00044616
- Locations
- 🇺🇸
Depression Research Unit, Univ Penn, Philadelphia, Pennsylvania, United States
Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder
- First Posted Date
- 2001-11-01
- Last Posted Date
- 2025-05-16
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 2350
- Registration Number
- NCT00025935
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
Sequenced Treatment Alternatives to Relieve Depression (STAR*D)
- Conditions
- Depression
- First Posted Date
- 2001-07-23
- Last Posted Date
- 2009-09-25
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 4000
- Registration Number
- NCT00021528
- Locations
- 🇺🇸
Harbor UCLA Family Health Care Center, Harbor City, California, United States
🇺🇸UCLA General Outpatient Psychiatry Clinic, Los Angeles, California, United States
🇺🇸UCLA Internal Medicine Clinic, Los Angeles, California, United States
Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
- Conditions
- Bipolar Disorder
- First Posted Date
- 2001-03-15
- Last Posted Date
- 2007-05-04
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 5000
- Registration Number
- NCT00012558
- Locations
- 🇺🇸
Case Western Reserve University, Cleveland, Ohio, United States
🇺🇸University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, United States
🇺🇸University of Pittsburgh, Pittsburgh, Pennsylvania, United States
Long-Term Lithium Treatment for Aggressive Conduct Disorder
- First Posted Date
- 1999-11-03
- Last Posted Date
- 2013-11-26
- Lead Sponsor
- Drexel University
- Target Recruit Count
- 59
- Registration Number
- NCT00000385
- Locations
- 🇺🇸
Drexel University College of Medicine at Friends Hospital, Philadelphia, Pennsylvania, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.