Esketamine
- Generic Name
- Esketamine
- Brand Names
- Spravato
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16ClNO
- CAS Number
- 33643-46-8
- Unique Ingredient Identifier
- 50LFG02TXD
- Background
Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide. On March 5, 2019, the nasal spray drug, esketamine, also known as Spravato (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression.
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- Indication
Esketamine is indicated in combination with an oral antidepressant for the treatment of treatment-resistant depression in adults. It is also indicated for the treatment of depressive symptoms in adults with major depressive disorder experiencing acute suicidal ideation or behaviour.
- Associated Conditions
- Major Depressive Disorder (MDD), Major depressive disorder, recurrent episode, Pain
- Associated Therapies
- Intubation
Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery
- Conditions
- Interventions
- First Posted Date
- 2023-10-02
- Last Posted Date
- 2023-10-04
- Lead Sponsor
- Peking University First Hospital
- Target Recruit Count
- 312
- Registration Number
- NCT06062550
- Locations
- 🇨🇳
Beijing University First Hospital, Beijing, Beijing, China
Fentanyl OR Esketamine for Traumatic PAIN (FORE-PAIN) Trial
- Conditions
- Interventions
- First Posted Date
- 2023-09-22
- Last Posted Date
- 2024-01-17
- Target Recruit Count
- 608
- Registration Number
- NCT06051227
- Locations
- 🇳🇱
Ambulance Amsterdam, Amsterdam, Netherlands
Effect of Quadratus Lumborum Block With Compound Lidocaine and Esketamine on Pain After Colorectal Surgery
- Conditions
- Interventions
- First Posted Date
- 2023-07-28
- Last Posted Date
- 2023-07-28
- Lead Sponsor
- Tianjin Medical University General Hospital
- Target Recruit Count
- 160
- Registration Number
- NCT05964985
Esketamine and Propofol for Children With Autism Spectrum Disorder Undergoing Colonoscopy
- Conditions
- Interventions
- First Posted Date
- 2023-07-19
- Last Posted Date
- 2023-10-10
- Target Recruit Count
- 46
- Registration Number
- NCT05951465
- Locations
- 🇨🇳
Sir Run Run Hospital, Nanjing, Jiangsu, China
Mini-dose Dexmedetomidine-Esketamine Infusion and Perioperative Sleep Quality
- Conditions
- Interventions
- First Posted Date
- 2023-07-18
- Last Posted Date
- 2023-11-24
- Lead Sponsor
- Peking University First Hospital
- Target Recruit Count
- 154
- Registration Number
- NCT05950646
- Locations
- 🇨🇳
Beijing Hospital, Beijing, Beijing, China
🇨🇳Peking University First Hospital, Beijing, Beijing, China
Clinical Study of Oral Midazolam Combined With Esketamine Administered Intranasally for Pediatric Preoperative Sedation
- Conditions
- Interventions
- First Posted Date
- 2023-06-29
- Last Posted Date
- 2023-06-29
- Target Recruit Count
- 126
- Registration Number
- NCT05925283
- Locations
- 🇨🇳
The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients
- Conditions
- Interventions
- First Posted Date
- 2023-05-03
- Last Posted Date
- 2023-11-22
- Lead Sponsor
- Nanfang Hospital, Southern Medical University
- Target Recruit Count
- 124
- Registration Number
- NCT05839366
- Locations
- 🇨🇳
Southern medical university Nanfang hospital, Guangzhou, China
Effects of Epidural Labor Analgesia With Esketamine on the Incidence of Postpartum Depression in Parturients
- First Posted Date
- 2023-04-24
- Last Posted Date
- 2024-08-20
- Target Recruit Count
- 364
- Registration Number
- NCT05826327
- Locations
- 🇨🇳
Women's hospital, school of medicine, Zhejiang university, Hangzhou, Zhejiang, China
Median Effective Dose of Esketamine Pretreatment to Prevent Sufentanil-induced Cough
- First Posted Date
- 2023-04-12
- Last Posted Date
- 2023-04-12
- Lead Sponsor
- Yangzhou University
- Target Recruit Count
- 30
- Registration Number
- NCT05809804
Dexmedetomidine-esketamine Combined Nasal Administration and Perioperative Sleep Quality
- Conditions
- Interventions
- First Posted Date
- 2023-02-16
- Last Posted Date
- 2023-05-25
- Lead Sponsor
- Peking University First Hospital
- Target Recruit Count
- 180
- Registration Number
- NCT05732064
- Locations
- 🇨🇳
Peking University First Hospital, Beijin, Bejing, China
Drug Development Updates
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