Overview
Allantoin is a substance that is endogenous to the human body and also found as a normal component of human diets . In healthy human volunteers, the mean plasma concentration of allantoin is about 2-3 mg/l. During exercise, the plasma allantoin concentration rapidly increases about two fold and remains elevated . In human muscle, urate is oxidized to allantoin during such exercise . The concentration of allantoin in muscles increases from a resting value of about 5000 ug/kg to about 16000 ug/kg immediately after short-term exhaustive cycling exercise . More specifically, allantoin is a diureide of glyoxylic acid that is produced from uric acid. It is a major metabolic intermediate in most organisms. Allantoin is found in OTC cosmetic products and other commercial products such as oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions . Allantoin has also demonstrated to ameliorate the wound healing process in some studies .
Indication
Allantoin is commonly applied in a variety of topical vehicles or applications such as cosmetic creams, toothpastes, mouthwashes, shampoos, lipsticks, anti-acne products, and lotions for the purpose of moisturizing skin, enhancing the smoothness of skin, stimulating the healing of wounds, and soothing irritated skin .
Associated Conditions
- Scarring
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2024/11/29 | Phase 1 | Recruiting | |||
2022/11/07 | Phase 1 | Active, not recruiting | |||
2022/02/02 | Phase 1 | Active, not recruiting | |||
2021/06/22 | Phase 1 | Active, not recruiting | |||
2017/10/26 | Phase 1 | Completed | |||
2017/01/02 | Phase 2 | Completed | David Oh | ||
2016/04/07 | Phase 1 | Terminated | |||
2016/03/15 | Not Applicable | Completed | Suleymaniye Birth And Women's Health Education And Research Hospital | ||
2016/02/01 | Phase 3 | Terminated | |||
2015/03/10 | Phase 3 | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Pharmaceutics Corporation | 49430-053 | TOPICAL | 2 mg in 1 1 | 3/20/2015 | |
| RENU LABORATORIES, LLC | 76348-720 | TOPICAL | 1.18 g in 118 mL | 5/6/2025 | |
| Aidance Scientific, Inc, DBA Aidance Skincare & Topical Solutions | 24909-034 | TOPICAL | 0.6 g in 100 g | 5/23/2025 | |
| TAGRID LLC | 85384-0007 | TOPICAL | 10 mg in 1 g | 5/8/2025 | |
| N/A | 50555-210 | ORAL | 0.05 g in 100 mL | 5/14/2025 | |
| Reedfresh Co., LTD | 85514-6538 | TOPICAL | 1 g in 100 g | 4/28/2025 | |
| Carolina Cannabis Creations LLC | 82876-224 | TOPICAL | 0.85 g in 118.76 g | 9/2/2025 | |
| Puretek Corporation | 59088-326 | TOPICAL | 22.5 mg in 1 g | 5/7/2025 | |
| Alivio Medical Products, LLC | 69512-020 | TOPICAL | 2 g in 100 g | 4/13/2015 | |
| Patchwerx Labs | 69329-011 | TOPICAL | 2 g in 100 g | 5/28/2015 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| ZINTOIN CREAM | N/A | N/A | N/A | 5/31/1986 | |
| BETOCAINE CREAM | N/A | N/A | N/A | 4/2/1990 | |
| ALOX CREAM | N/A | N/A | N/A | 5/31/1986 | |
| CONTRACTUBEX OINT | N/A | N/A | N/A | 6/4/1983 | |
| SKINDERM CREAM | N/A | N/A | N/A | 9/19/1987 |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| MEDIPULV ANTISEPTIC POWDER topical dusting powder tube | 16129 | Pharmacare Laboratories Pty Ltd | Medicine | A | 10/3/1991 |
| APURA SKIN PREPARATION SKIN RELIEF CREAM tube | 91426 | Medicine | A | 10/22/2002 | |
| APURA SKIN PREPARATIOIN BLEMISH CONTROL GEL tube | 91428 | Medicine | A | 10/22/2002 | |
| APURA SKIN PREPARATION SCALP RELIEF SHAMPOO bottle | 91422 | Medicine | A | 10/22/2002 |
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| ELTA DERMAL WOUND CLEANSER | swiss american products inc. | 02231349 | Lotion - Topical | 2 % | N/A |
| ALPHOSYL LOTION | reed & carnrick, division of block drug company (canada) ltd. | 00167800 | Lotion - Topical | 2 % | 12/31/1958 |
| W15883-CS | warner-lambert canada inc. | 02240584 | Ointment - Topical | 1.5 % | N/A |
| VIONEX SKIN PROTECTANT CREAM | metrex research, llc | 02245489 | Cream - Topical | 0.51 % | 2/11/2002 |
| OPTREX EYE DROPS | schering-plough healthcare products canada, a division of schering canada inc. | 02236576 | Drops - Ophthalmic | 0.08 % | 8/20/1998 |
| MOISTURE EXTREME SPF 15 | maybelline canada | 02274701 | Stick - Topical | 0.6 % | 7/31/2006 |
| TEGRIN CREAM | block drug company (canada) ltd. | 00067229 | Cream - Topical | 1.97 % | 12/31/1963 |
| NATURAL ICE HEALER | the mentholatum company of canada ltd | 02242614 | Ointment - Topical | 1 % | 10/1/2001 |
| ELTA DERMAL GEL FOR WOUND DRESSING | swiss american products inc. | 02231350 | Gel - Topical | 2 % | N/A |
| OPTREX EYE DROPS | knoll pharma inc. | 02185482 | Drops - Ophthalmic | 0.08 % | 12/31/1996 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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