Aminophylline

Generic Name: Aminophylline

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₂₄N_₁₀O_₄

CAS Number: 317-34-0

Unique Ingredient Identifier: 27Y3KJK423

Background: Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic bronchitis, and COPD. The majority of aminophylline medications are discontinued and the remaining medications on the market are in short supply.

Indication: For the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.

Associated Conditions: Acute Exacerbation of Chronic Bronchitis (AECB), Asthma, Bronchial Asthma, Bronchospasm, Chronic Bronchitis, Exacerbation of asthma

Clinical Trials

The Effect of Preoperative Aminophylline

Phase 1

Conditions: Recovery From Anesthesia

Interventions: Drug: Aminophylline

First Posted Date: 2019-11-05

Last Posted Date: 2019-11-05

Lead Sponsor: Beni-Suef University

Target Recruit Count: 45

Registration Number: NCT04151381

Locations: 🇪🇬
Beni-Suef University Hospital, Banī Suwayf, Egypt
🇪🇬
Faculty of Medicine, Beni-SuefUniversity, Banī Suwayf, Egypt

Effect of Compound Sodium Chlorate and Aminophylline Tablets on Chronic Obstructive Pulmonary Disease(COPD).

Phase 4

Recruiting

Conditions: Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Interventions: Drug: Compound Ipratropium Bromide Solution(C1) for Inhalation
Drug: Placebo Tablets
Drug: Compound Sodium Chlolate and Aminophylline Tablets(C2)

First Posted Date: 2019-09-24

Last Posted Date: 2019-09-24

Lead Sponsor: Wuhan Union Hospital, China

Target Recruit Count: 200

Registration Number: NCT04101500

Locations: 🇨🇳
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Is Aminophylline More Effective Than Neostigmine/Atropine Mixture in the Treatment of Post-dural Puncture Headache

Phase 4

Completed

Conditions: Post-Dural Puncture Headache

Interventions: Drug: IV Aminophylline
Drug: IV Neostigmine Methylsulfate + Atropine Sulphate

First Posted Date: 2019-06-25

Last Posted Date: 2020-02-05

Lead Sponsor: Damanhour Teaching Hospital

Target Recruit Count: 60

Registration Number: NCT03997006

Locations: 🇪🇬
Damanhour Teaching Hospital, Damanhūr, El-Beheira, Egypt

Preventing Acute Kidney Injury (AKI) in Pediatric Patients

Phase 3

Conditions: Acute Kidney Injury

Interventions: Drug: Placebo
Drug: Aminophylline

First Posted Date: 2019-04-01

Last Posted Date: 2022-04-18

Lead Sponsor: Le Bonheur Children's Hospital

Target Recruit Count: 80

Registration Number: NCT03897335

Locations: 🇺🇸
LeBonheur Children's Hospital, Memphis, Tennessee, United States

Non-invasive Ventilation vs. Standard Therapy for Children Hospitalized With an Acute Exacerbation of Asthma

Not Applicable

Conditions: Asthma Acute
Asthma in Children

Interventions: Device: CPAP
Device: BiPAP
Drug: Ipratropium
Drug: Magnesium Sulfate
Drug: Aminophylline
Drug: Standard steroid dose, hourly salbutamol, oxygen as needed

First Posted Date: 2017-09-28

Last Posted Date: 2018-05-02

Lead Sponsor: University of British Columbia

Target Recruit Count: 100

Registration Number: NCT03296579

Progesterone and Aminophylline for the Prevention of Preterm Labour

Phase 1

Conditions: Premature Obstetric Labor

Interventions: Drug: Progesterone
Drug: Aminophylline

First Posted Date: 2017-05-15

Last Posted Date: 2018-02-28

Lead Sponsor: St Stephens Aids Trust

Target Recruit Count: 70

Registration Number: NCT03152942

Locations: 🇬🇧
Chelsea and Westminster Hospital, London, United Kingdom

Effects of Aminophylline on Renal Function and Urine Volume of AKI Patient

Early Phase 1

Conditions: Acute Kidney Injury

Interventions: Drug: aminophylline
Drug: normal saline
Drug: frusemide

First Posted Date: 2016-12-06

Last Posted Date: 2016-12-06

Lead Sponsor: Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Target Recruit Count: 60

Registration Number: NCT02983422

Aminophylline for Patients With Post-Dural Puncture Headache

Phase 3

Completed

Conditions: Post-dural Puncture Headache

Interventions: Drug: isotonic saline
Drug: Aminophylline

First Posted Date: 2015-08-13

Last Posted Date: 2016-10-31

Lead Sponsor: The First Affiliated Hospital of Zhengzhou University

Target Recruit Count: 126

Registration Number: NCT02522013

Locations: 🇨🇳
Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, China
🇨🇳
Jinzhou central hospital, Jinzhou, Liaoning, China
🇨🇳
Suzhou municipal hospital, Suzhou, Anhui, China

and more 1 locations

A Pilot Study Into Health Pre and Post Treatment With Intravenous Aminophylline and Hydrocortisone in Severe Asthmatics

Terminated

Conditions: Asthma

First Posted Date: 2014-10-21

Last Posted Date: 2015-10-28

Lead Sponsor: Royal Brompton & Harefield NHS Foundation Trust

Target Recruit Count: 5

Registration Number: NCT02270827

Locations: 🇬🇧
Royal Brompton Hospital, London, United Kingdom

A Study to Test the Safety of Combined Dosing With Aminophylline and Ambrisentan in Exercising Healthy Human Volunteers at Simulated High Altitude

Phase 1

Completed

Conditions: Acute Mountain Sickness and Fatigue

Interventions: Drug: Aminophylline 400 mg
Other: Placebo
Drug: Ambrisentan 5 mg

First Posted Date: 2013-02-18

Last Posted Date: 2015-11-13

Lead Sponsor: Robert J Noveck, M.D.

Target Recruit Count: 92

Registration Number: NCT01794078

Locations: 🇺🇸
Duke Center for Hyperbaric Medicine, Durham, North Carolina, United States
🇺🇸
Duke Clinical Research Unit (DCRU), Durham, North Carolina, United States

Drug Development Updates

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