Aminophylline
- Generic Name
- Aminophylline
- Drug Type
- Small Molecule
- Chemical Formula
- C16H24N10O4
- CAS Number
- 317-34-0
- Unique Ingredient Identifier
- 27Y3KJK423
- Background
Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic bronchitis, and COPD. The majority of aminophylline medications are discontinued and the remaining medications on the market are in short supply.
- Indication
For the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
- Associated Conditions
- Acute Exacerbation of Chronic Bronchitis (AECB), Asthma, Bronchial Asthma, Bronchospasm, Chronic Bronchitis, Exacerbation of asthma
Comparison of the Effect of Aminophylline, Magnesium Sulphate and Placebo in Prevention of Post Dural Puncture Headache in Parturient Undergoing Caesarean Section.
- Conditions
- Post-Dural Puncture Headache
- Interventions
- First Posted Date
- 2024-02-22
- Last Posted Date
- 2024-02-22
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 630
- Registration Number
- NCT06272916
Prevention of Cisplatin-induced Nephrotoxicity
- Conditions
- Renal TubulopathyAcute Kidney Injury
- Interventions
- First Posted Date
- 2024-01-09
- Last Posted Date
- 2024-01-09
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 24
- Registration Number
- NCT06196853
- Locations
- 🇹🇭
Siriraj hospital, Mahidol university, Bangkok, Thailand
Effects of Aminophylline Bolus on TCI (Target Controlled Infusion) Concentrations at Burst Suppression Occurence
- First Posted Date
- 2023-11-18
- Last Posted Date
- 2024-04-25
- Lead Sponsor
- University of Padova
- Target Recruit Count
- 32
- Registration Number
- NCT06134037
- Locations
- 🇮🇹
Treviso Regional Hospital, Treviso, TV, Italy
Effects of Aminophylline Bolus on TCI (Target Controlled Infusion) Concentrations at Return of Responsiveness
- First Posted Date
- 2023-10-24
- Last Posted Date
- 2024-04-25
- Lead Sponsor
- University of Padova
- Target Recruit Count
- 48
- Registration Number
- NCT06098196
- Locations
- 🇮🇹
ULSS2 Marca Trevigiana, Treviso, Italy
🇮🇹ULSS 2 Marca Trevigiana, Treviso, Tv, Italy
Diuretic Efficacy of Aminophylline and Furosemide Combination vs Furosemide Alone in Critically Ill Adults
- First Posted Date
- 2023-07-06
- Last Posted Date
- 2023-07-11
- Lead Sponsor
- University of Malaya
- Target Recruit Count
- 132
- Registration Number
- NCT05933642
- Locations
- 🇲🇾
University of Malaya, Kuala Lumpur, Malaysia
Aminophylline on Recovery in Functional Endoscopic Sinus Surgery Under Dexmedetomidine Hypotensive Anesthesia
- Conditions
- AminophyllineFunctional Endoscopic Sinus SurgeryDexmedetomidine
- Interventions
- Drug: normal saline
- First Posted Date
- 2023-02-21
- Last Posted Date
- 2023-08-29
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 52
- Registration Number
- NCT05738135
- Locations
- 🇪🇬
Tanta University Hospitals, Tanta, ElGharbiaa, Egypt
Aminophylline Infusion on Pain Intensity After Ureterocopic Lithotripsy
- Conditions
- PainUreterocopic LithotripsyAminophylline
- Interventions
- Other: Control group
- First Posted Date
- 2023-01-30
- Last Posted Date
- 2023-06-27
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 50
- Registration Number
- NCT05705050
- Locations
- 🇪🇬
Tanta University Hospitals, Tanta, ElGharbiaa, Egypt
Reversal of Complete Heart Block With Aminophylline in Inferior Wall Myocardial Infarction Patients
- Conditions
- Complete Heart BlockInferior Wall Myocardial Infarction
- Interventions
- First Posted Date
- 2022-12-27
- Last Posted Date
- 2022-12-27
- Target Recruit Count
- 73
- Registration Number
- NCT05666219
Effect of Aminophylline Bolus Versus Infusion on Recovery Time in Patients Undergoing Lumbar Spine Surgery
- Conditions
- Anesthesia
- Interventions
- First Posted Date
- 2022-12-19
- Last Posted Date
- 2023-01-04
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 33
- Registration Number
- NCT05655806
- Locations
- 🇪🇬
Kasr Alainy, Cairo, Egypt
Postdural Puncture Headache Relief With Aminophylline and SPGB
- Conditions
- Anesthesia
- Interventions
- First Posted Date
- 2022-09-23
- Last Posted Date
- 2023-01-11
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 75
- Registration Number
- NCT05552404
- Locations
- 🇪🇬
faculty of medicine, Ain Shams University, Cairo, Egypt
Drug Development Updates
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