Effect of Intraoperative Aminophylline Infusion on Pain Intensity After Ureterocopic Lithotripsy Surgeries
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Intensity of pain
研究概览
简要总结
This study will be conducted to evaluate the effect of intraoperative systemic aminophylline infusion on pain intensity in patients undergoing ureteroscopic lithotripsy surgeries with ureteric stent placement at the end of the procedure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged between 18 to 50 years
- •American society of anesthesiology (ASA) physical status I - II
- •Body mass index (BMI) less than 30.0 kg/m2
- •Scheduled for ureteroscopic lithotripsy surgery with D-J ureteric stent placement at the end of procedure
- •Under general anesthesia.
排除标准
- •Patients with central nervous system diseases, cardiovascular diseases, arrhythmias, cerebrovascular diseases, convulsions, renal impairment or hepatic dysfunction.
- •Pregnancy or lactation.
- •Patients with a history of allergy to aminophylline.
- •Coffee consumption (more than 2 cups/day)
- •Patients with opioid addiction or patients treated with B agonists, tranquilizers, or antidepressants.
- •Short procedures less than 30 minutes or procedures not requiring D-J stent placement.
研究组 & 干预措施
Aminophylline group
Patients will receive 4 mg/kg aminophylline diluted in 100 ml normal saline over 20 minutes after induction of anesthesia and positioning of patients in lithotomy position.
干预措施: Aminophylline group (Drug)
Control group
Patients will receive 100 ml normal saline over 20 minutes after induction and lithotomy positioning.
干预措施: Control group (Other)
结局指标
主要结局
Intensity of pain
时间窗: In post anesthesia care unit (PACU)
Visual analogue score (VAS) score: will be measured on arrival to PACU, at 30 minutes, 1 hour, 2 hour, 6, 12 and 24 hour after surgery.
次要结局
- The incidence of postoperative adverse reactions(24 hour after surgery)
- Intensity of pain(24 hour after surgery)
- Total amount of opioid dose(24 hour after surgery)
研究者
Osama Rehab
Lecturer of Anesthesiology, Intensive Care and Pain Medicine
Tanta University