Effect of Intravenous Aminophylline on Hemodynamics and Recovery of Patients Undergoing Functional Endoscopic Sinus Surgery Under Dexmedetomidine Hypotensive Anesthesia: A Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Time to extubation
研究概览
简要总结
This study will be conducted to evaluate the effect of intravenous aminophylline on hemodynamics and recovery of patients receiving dexmedetomidine infusion during functional endoscopic sinus surgery.
详细描述
Aminophylline is a nonselective adenosine receptor antagonist used for the treatment of asthma and chronic obstructive pulmonary disease. It has been used to antagonize the effects of anaesthetic and analgesic agents
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients aged between 18 to 50 years, have American society of anesthesiology (ASA) physical status I - II and scheduled for elective FESS under general anesthesia and receiving dexmedetomidine infusion for controlled hypotension during surgery.
排除标准
- •Patients with central nervous system diseases, cardiovascular diseases, hypertension, arrhythmias, cerebrovascular diseases, convulsions, renal impairment or hepatic dysfunction.
- •Pregnancy or lactation.
- •Patients with a history of allergy to aminophylline.
- •Patients with recurrent sinus surgery, hypertension.
研究组 & 干预措施
Aminophylline group
Patients will receive 4 mg/kg aminophylline diluted in 50 ml normal saline over 30 minutes.
干预措施: Aminophylline group (Drug)
Control group
Patients will receive 50 ml normal saline over 30 minutes.
干预措施: normal saline (Drug)
结局指标
主要结局
Time to extubation
时间窗: Two hours after discontinuation of anesthetics
Extubation time, defined as the interval between the discontinuation of anesthetics to safe tracheal extubation.
次要结局
- Intraoperative mean arterial blood pressure(Intraoperative period)
- Time to discharge from post anesthesia care unit(Two hours after tracheal extubation.)
- Intraoperative heart rate(Intraoperative period)
- Postoperative sedation score(60 minutes after tracheal extubation)
研究者
Osama Rehab
Lecturer of Anesthesiology, Intensive Care and Pain Medicine
Tanta University