Salsalate is a nonsteroidal anti-inflammatory agent for oral administration. Salsalate's mode of action as an anti-inflammatory and antirheumatic agent may be due to inhibition of synthesis and release of prostaglandins. The usefulness of salicylic acid, the active in vivo product of salsalate, in the treatment of arthritic disorders has been established. In contrast to aspirin, salsalate causes no greater fecal gastrointestinal blood loss than placebo. Salsalate is readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. A significant portion of the parent compound is absorbed unchanged and undergoes rapid esterase hydrolysis in the body. The parent compound has an elimination half-life of about 1 hour. Salicylic acid (the active metabolite) biotransformation is saturated at anti-inflammatory doses of salsalate. Such capacity limited biotransformation results in an increase in the half-life of salicylic acid from 3.5 to 16 or more hours.
For relief of the signs and symptoms of rheumatoid arthritis, osteoarthritis and related rheumatic disorders.
University of Iowa, Iowa City, Iowa, United States
University of Massaschusetts Medical School, Worcester, Massachusetts, United States
Johns Hopkins University Geriatrics Center, Baltimore, Maryland, United States
Lakeview Medical Research, Summerfield, Florida, United States
St Joseph's/Candler Health System, Savannah, Georgia, United States
Indiana University Hospital, Indianapolis, Indiana, United States
University of Michigan, Ann Arbor, Michigan, United States
Baltimore VA Medical Center, Baltimore, Maryland, United States
Maryland Psychiatric Research Center, Baltimore, Maryland, United States
University Hospitals Case Medical Center, Cleveland, Ohio, United States
Emory University School of Medicine, Atlanta, Georgia, United States
Kaiser Permanente, Tucker, Georgia, United States
University of Texas Southwestern, Dallas, Texas, United States
Brigham and Women's Hospital, Boston, Massachusetts, United States
Joslin Diabetes Center, Boston, Massachusetts, United States
Heart Center of Metrowest, Framingham, Massachusetts, United States
Seacoast Cardiology, York, Maine, United States
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