Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
the Effects of Epidural Fentanyl on Vaginal Delivery
- Conditions
- Cervical DilatationBishop ScoreDuration of Delivery
- Interventions
- Drug: FentanylDrug: Normal saline
- First Posted Date
- 2014-05-09
- Last Posted Date
- 2014-05-09
- Lead Sponsor
- University of Athens
- Target Recruit Count
- 60
- Registration Number
- NCT02135224
- Locations
- 🇬🇷
Aretaieio Hospital, University of Athens, Athens, Attiki, Greece
Horner's SD After Thoracic Epidural Block
- Conditions
- Horner's Syndrome
- Interventions
- Procedure: thoracic epidural anesthesiaProcedure: mastectomyDrug: RopivacaineDrug: PropofolDrug: Fentanyl
- First Posted Date
- 2014-05-05
- Last Posted Date
- 2014-05-05
- Lead Sponsor
- Soonchunhyang University Hospital
- Target Recruit Count
- 450
- Registration Number
- NCT02130739
- Locations
- 🇰🇷
Soonchunhyang University Seoul Hospital, Seoul, Korea, Republic of
The Value of Adding Either Meperdine or Fentanyl to Clonidine-bupivacaine
- First Posted Date
- 2014-05-01
- Last Posted Date
- 2015-04-07
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 90
- Registration Number
- NCT02128451
- Locations
- 🇪🇬
Faculty of Medicine ,Tanta University., Tanta, Algharbiya, Egypt
🇪🇬Tanta University Hospitals, Tanta, Algharbyia, Egypt
Effectiveness of Intranasal Versus Intravenous Fentanyl in Preterm and Term Newborns for Pain Prevention
- First Posted Date
- 2014-04-29
- Last Posted Date
- 2018-02-06
- Lead Sponsor
- HaEmek Medical Center, Israel
- Target Recruit Count
- 21
- Registration Number
- NCT02125201
- Locations
- 🇮🇱
NICU, Afula, Israel
Sequential Use of Propofol/Midazolam and Dexmedetomidine for Sedation in Mechenical Ventialtion Patients in ICU.
- Conditions
- Mechanical Ventilation Complication
- Interventions
- Drug: FentanylProcedure: Sedation assessmentProcedure: Screen of weaningDrug: PropofolDrug: MidazolamDrug: Dexmedetomidine
- First Posted Date
- 2014-04-24
- Last Posted Date
- 2014-04-24
- Lead Sponsor
- Tianjin Third Central Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT02122055
Decreasing the Incidence of Delirium After Cardiac Surgery
- Conditions
- C.Surgical Procedure; CardiacDelirium
- Interventions
- First Posted Date
- 2014-04-22
- Last Posted Date
- 2018-06-12
- Lead Sponsor
- University of California, Los Angeles
- Registration Number
- NCT02119806
- Locations
- 🇺🇸
Ronald Reagan UCLA Medical Center, Department of Anesthesiology, Los Angeles, California, United States
Epidural Calcitonin in Lower Limb Amputation
- First Posted Date
- 2014-04-16
- Last Posted Date
- 2016-08-31
- Lead Sponsor
- Tanta University
- Target Recruit Count
- 60
- Registration Number
- NCT02115360
- Locations
- 🇪🇬
Tanta University Hospitals, Tanta, Algharbyia, Egypt
μ-opioid Receptor Polymorphism and Opioid Analgesia
- Conditions
- Pharmacogenetic and Duration of Labor Fentanyl Analgesia
- Interventions
- First Posted Date
- 2014-03-31
- Last Posted Date
- 2018-02-22
- Lead Sponsor
- American University of Beirut Medical Center
- Target Recruit Count
- 250
- Registration Number
- NCT02099877
- Locations
- 🇱🇧
American University of Beirut, Beirut, Lebanon
Safety and Efficacy of Combined Sedation With Midazolam and Dexmedetomidine in ICU Patients
- First Posted Date
- 2014-03-06
- Last Posted Date
- 2014-03-06
- Lead Sponsor
- Qilu Hospital of Shandong University
- Target Recruit Count
- 600
- Registration Number
- NCT02080169
- Locations
- 🇨🇳
Department ICU, Shandong university affiliated Qilu Hospital., Jinan, Shandong, China
The Effect of Analgesia Based Sedation Protocol on Brain Function of Critical Care Patients
- First Posted Date
- 2014-03-05
- Last Posted Date
- 2014-07-16
- Lead Sponsor
- Peking University People's Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT02078583
Drug Development Updates
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