Fentanyl

Generic Name: Fentanyl

Brand Names: Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₈N_₂O

CAS Number: 437-38-7

Unique Ingredient Identifier: UF599785JZ

Background: Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.

Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.

Fentanyl was FDA approved in 1968.

Indication: Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.

Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.

Associated Conditions: Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain

Associated Therapies: Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy

Clinical Trials

Dexmedetomidine Versus Fentanyl Following Pressure Equalization Tube Placement

Phase 2

Completed

Conditions: Chronic Otitis Media

Interventions: Drug: Dexmedetomidine
Drug: Fentanyl
Drug: Midazolam

First Posted Date: 2010-08-25

Last Posted Date: 2014-04-01

Lead Sponsor: Nationwide Children's Hospital

Target Recruit Count: 100

Registration Number: NCT01188551

Locations: 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States

Fentanyl vs. Low-Dose Ketamine for the Relief of Moderate to Severe Pain in Aeromedical Patients

Not Applicable

Withdrawn

Conditions: Trauma
Pain

Interventions: Drug: Fentanyl
Drug: Ketamine

First Posted Date: 2010-07-23

Last Posted Date: 2012-06-04

Lead Sponsor: University of Utah

Registration Number: NCT01169025

Locations: 🇺🇸
University of Utah Medical Center, Salt Lake City, Utah, United States

Population Pharmacokinetics of Fentanyl in Patients Undergoing Living Donor Liver Transplantation

Not Applicable

Completed

Conditions: Living Donor Liver Transplantation

Interventions: Drug: Fentanyl

First Posted Date: 2010-06-15

Last Posted Date: 2011-06-22

Lead Sponsor: Asan Medical Center

Target Recruit Count: 20

Registration Number: NCT01144312

Locations: 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of

Combined Ketamine/Propofol for Emergency Department Procedural Sedation

Not Applicable

Terminated

Conditions: Procedural Sedation and Analgesia

Interventions: Drug: Placebo
Drug: Ketamine
Drug: Fentanyl
Drug: Propofol

First Posted Date: 2010-05-20

Last Posted Date: 2023-04-24

Lead Sponsor: University of Missouri-Columbia

Target Recruit Count: 107

Registration Number: NCT01126957

Locations: 🇺🇸
University of Missouri - Columbia dept. of Emergency Medicine, Columbia, Missouri, United States

Labetalol and Esmolol: Vital Signs and Post Operative Pain Management

Phase 4

Completed

Conditions: Laparoscopic Surgery

Interventions: Drug: Labetalol
Drug: Fentanyl
Drug: Esmolol

First Posted Date: 2010-05-03

Last Posted Date: 2020-02-20

Lead Sponsor: Cedars-Sinai Medical Center

Target Recruit Count: 75

Registration Number: NCT01114971

Locations: 🇺🇸
Cedars Sinai Medical Center, Los Angeles, California, United States

Patient-controlled Sedation With Propofol and Remifentanyl for Endoscopic Retrograde Cholangiopancreatography (ERCP)

Phase 4

Completed

Conditions: Endoscopic Retrograde Cholangiopancreatography

Interventions: Device: infusion pump
Device: infusion pump for patient-controlled sedation
Drug: propofol
Drug: fentanyl
Drug: sedative mixture
Drug: remifentanil hydrochlorid