Fentanyl

Generic Name: Fentanyl

Brand Names: Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₈N_₂O

CAS Number: 437-38-7

Unique Ingredient Identifier: UF599785JZ

Background: Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.

Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.

Fentanyl was FDA approved in 1968.

Indication: Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.

Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.

Associated Conditions: Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain

Associated Therapies: Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy

Clinical Trials

Analgesic Additives to Epidural Bupivacaine in Normal Labor

Not Applicable

Not yet recruiting

Conditions: Labor Pain

Interventions: Drug: Dexmedetomidine
Drug: fentanyl
Drug: Nalbuphine

First Posted Date: 2023-02-27

Last Posted Date: 2023-02-27

Lead Sponsor: Assiut University

Target Recruit Count: 69

Registration Number: NCT05746351

Observational Study on the Incorporation of Opioids and Their Metabolites Into Hair of Pediatric Patients

Completed

Conditions: Opioid Use, Unspecified

Interventions: Drug: Fentanyl

First Posted Date: 2023-02-23

Last Posted Date: 2025-03-30

Lead Sponsor: University of Zurich

Target Recruit Count: 150

Registration Number: NCT05740657

Locations: 🇨🇭
University's Children Hospital, Zurich, Switzerland

Effect of Neurostimulator Usage on Block Success

Not Applicable

Completed

Conditions: PATIENTS WITH UPPER EXTREMITY SURGERY

Interventions: Drug: fentanyl will be added
Procedure: general anesthesia

First Posted Date: 2023-01-31

Last Posted Date: 2023-01-31

Lead Sponsor: Gaziosmanpasa Research and Education Hospital

Target Recruit Count: 60

Registration Number: NCT05706090

Locations: 🇹🇷
Gazoosmanpasa Education and Research Hospital, Istanbul, Turkey

Efficacy and Safety of Remifentanil for Mechanically Ventilated Patients in Intensive Care Unit

Phase 3

Recruiting

Conditions: Analgesia

Interventions: Drug: Remifentanil
Drug: Fentanyl

First Posted Date: 2022-12-08

Last Posted Date: 2022-12-08

Lead Sponsor: Southeast University, China

Target Recruit Count: 138

Registration Number: NCT05641909

Locations: 🇨🇳
Anhui Provincial People's Hospital, Hefei, Anhui, China
🇨🇳
The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing, China
🇨🇳
First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

and more 15 locations

Affective Effects of Pre-surgery Opioids: a Randomized, Doubleblind Placebo-controlled Trial

Phase 4

Recruiting

Conditions: Opioid Use
Affective Symptoms

Interventions: Drug: Oxycodone 2.5 mg i.v.
Drug: Oxycodone 5 mg i.v.
Drug: Oxycodone 10 mg i.v.
Drug: Morphine 10 mg i.v.
Drug: Fentanyl 0.1 mg i.v.
Drug: Placebo
Drug: Morphine 2.5 mg i.v.
Drug: Morphine 5 mg i.v.
Drug: Fentanyl 0.025 mg i.v.
Drug: Fentanyl 0.05 mg i.v.

First Posted Date: 2022-12-06

Last Posted Date: 2023-09-18

Lead Sponsor: Oslo University Hospital

Target Recruit Count: 1000

Registration Number: NCT05639712

Locations: 🇳🇴
Harald Lenz, Oslo, Norway

Muscle Reflex Inhibition in Hypoxic Exercise

Not Applicable

Not yet recruiting

Conditions: Dyspnea
Muscle Strain

Interventions: Other: Saline
Drug: Fentanyl

First Posted Date: 2022-11-17

Last Posted Date: 2022-11-23

Lead Sponsor: University of British Columbia

Target Recruit Count: 14

Registration Number: NCT05619887

Locations: 🇨🇦
University of British Columbia - Okanagan Campus, Kelowna, British Columbia, Canada

The NONA-LISA Trial

Not Applicable

Recruiting

Conditions: Respiratory Distress Syndrome in Premature Infant

Interventions: Procedure: Less Invasive Surfactant Administration (LISA)
Drug: Isotonic saline
Drug: Fentanyl
Behavioral: Non-pharmacological standard operating procedure

First Posted Date: 2022-11-08

Last Posted Date: 2024-07-16

Lead Sponsor: Rigshospitalet, Denmark

Target Recruit Count: 324

Registration Number: NCT05609877

Locations: 🇩🇰
Neonatalafsnittet, Børn- og Ungeafdelingen, Reberbansgade 15, Aalborg, Denmark
🇩🇰
Department of Paediatrics (Intensive Care Neonatology) and Perinatal Research Unit, Aarhus, Denmark
🇩🇰
Department of Neonatal and Pediatric Intensive Care, Blegdamsvej 9, Copenhagen, Denmark

and more 1 locations

Ultrasound Guided Erector Spinae Block vs Thoracolumbar Interfascial Plane Block

Not Applicable

Completed

Conditions: Analgesia
Lumbar Spine Disease

Interventions: Drug: Propofol
Drug: Fentanyl
Drug: Rocuronium
Drug: Sevoflurane
Other: Erector spinae plane block
Other: Thoracolumbar interfascial plane block