Paracetamol Plus Tramadol Versus Fentanyl in Day Case Surgeries
- Conditions
- Post Operative Pain
- Interventions
- Registration Number
- NCT05990686
- Lead Sponsor
- Zagazig University
- Brief Summary
Postoperative pain is an important problem, especially for day case surgeries. It has negative effects on patient's hemodynamics and can cause delayed ambulation resulting in prolonged duration of hospital stay and poor patient satisfaction.
Multiple analgesic strategies have been proposed including NSAID, opioids, epidural analgesia. Each of them has its limitations.
In this study the investigators will compare between the effect of preemptive use of paracetamol plus tramadol versus preemptive intravenous fentanyl in controlling postoperative pain
- Detailed Description
After routine pre-operative evaluation, standard monitors will be connected to the patients: pulse oximetery, non invasive blood pressure and electrocardiogram and baseline parameter will be recorded (heart rate, mean arterial pressure and peripheral oxygen saturation). Intravenous (IV) line will be inserted for all patients, and IV fluid will be started.
Patients will be allocated into two equal groups;
Group (T) (n=66):
Intravenous infusion of 15mg/kg paracetamol together with 1mg/kg tramadol will be started and to be finished before starting of induction of anesthesia (induction agent will be Propofol 2mg/kg)
Group ( F ) (n=66):
Intravenous injection of 1microgram/kg fentanyl will be given to the patient followed by induction agents ( Propofol 2mg/kg).
In both groups intraoperative monitoring of heart rate (beat/min) and mean arterial blood pressure (mm gh) will be documented.
Postoperatively:
In the recovery room and in the surgical ward patient's mean blood pressure and heart rate will be measured and recorded at 1, 2, 4, 6, and 12 hours postoperatively. Also the postoperative pain assessment for all patients will be done by an anesthesiologist (independent observer) at 1, 2, 4, 6 and 12 hours after surgery based on visual analog scale (VAS) ( a 10-cm line labeled with "worst pain imaginable" on the right border and "no pain" on the left border). The patient is instructed to make a mark along the line to represent the intensity of pain currently being experienced.
Standard postoperative analgesia consisted of paracetamol 1gm i.v. after 6 hours. A rescue analgesic diclofenac 75mg IV infusion will be applied to patients if their VAS score was ≥ 3 and if paracetamol had been administered less than 6 hours before. Time of first required dose of rescue analgesic and total rescue analgesic consumption over the 24-h study period will be documented.
Rescue antiemetics will be given to any patient complaining of nausea and vomiting, occurrence of other side effects including bradycardia or hypotension will be recorded and managed (hypotension defined as a decrease in mean arterial pressure (MAP) of more than 20% of baseline value and planned to be treated with crystalloid infusion and 5 mg bolus of ephedrine, Bradycardia is considered if the heart rate (HR) went below 50 b/min and planned to be managed with atropine 0.2-0.5 mg). Patient satisfaction and length of postoperative hospital stay will also be recorded.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 132
- Patients scheduled for day case surgeries.
- Both sex
- Patient's age 21 - 60 years.
- Patients with ASA physical status I, II.
- BMI 25 - 30 kg m-2.
- Uncooperative patients and patients with psychological problems.
- Patients with liver or renal impairment..
- Patients with history of allergy to drug used in the study.
- Patients with chronic pain.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description paracetamol plus tramadol Tramadol Hydrochloride randomized selection of 66 adult patients fentanyl Fentanyl injection randomized selection of 66 adult patients
- Primary Outcome Measures
Name Time Method postoperative analgesia immediately postoperative (0 hour), 1 hour, 2 hours , 4 hours, 6 hours and 12 hours Assess quality of postoperative analgesia in both groups analogue score (VAS) scale where zero means no pain and ten means worst pain
- Secondary Outcome Measures
Name Time Method side effects up to twenty four hours after surgery document the incidence of side effects including: bradycardia, hypotension, nausea and vomiting
mean arterial Blood pressure 5 minutes after start of surgery (intraoperative) , immediately after surgery (0 hour) , 1 hour, 2 hours , 4 hours , 6 hours and 12 hours after surgery Compare mean arterial blood pressure in (mm hg) between patients in both groups
rescue analgesic immediately after surgery (0 hour) , 1 hour, 2 hours , 4 hours , 6 hours and 12 hours after surgery document the first time for the need of rescue analgesics
length of hospital stay up to twenty four hours after surgery Compare the length of hospital stay in both groups
Heart Rate 5 minutes after start of surgery ( intraoperative), immediately after surgery (0 hour) , 1 hour, 2 hours , 4 hours , 6 hours and 12 hours after surgery compare the heart rate in rate per minutes (rpm) between patients in both groups
Trial Locations
- Locations (1)
Zagazig University , Fuculty of Medicine
🇪🇬Zagazig, Sharquia, Egypt