Urokinase
- Generic Name
- Urokinase
- Brand Names
- Kinlytic
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 9039-53-6
- Unique Ingredient Identifier
- 83G67E21XI
- Background
Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond.
Urokinase was granted FDA approval on 16 January 1978.
- Indication
In Canada, urokinase is indicated for lysis of acute massive pulmonary emboli, acute thrombi obstructing coronary arteries, occlusive thromboemboli in peripheral arteries and grafts, and restoration of patency to intravenous catheters.
- Associated Conditions
- Obstruction; Catheter, Infusion Catheter (Vascular), Pulmonary Embolism, Pulmonary Embolism Acute Massive, Thromboembolism of the Coronary Artery, Thromboembolism of the Graft, Thromboembolism of the Peripheral Artery
- Associated Therapies
- -
Early Lumbar Drainage Combined With Intrathecal Urokinase Injection for Treatment of Severe Aneurysmal SAH (LD-ITUK)
- Conditions
- Interventions
- First Posted Date
- 2024-02-29
- Last Posted Date
- 2024-04-15
- Target Recruit Count
- 424
- Registration Number
- NCT06284642
- Locations
- 🇨🇳
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
Treatment of Acute Ischemic StroKe With Intravenous UroKinase Real-world Research: a Multicenter, Prospective Study
- First Posted Date
- 2024-01-08
- Last Posted Date
- 2024-01-08
- Target Recruit Count
- 1800
- Registration Number
- NCT06194968
- Locations
- 🇨🇳
Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
🇨🇳Red Cross Hospital of Yulin City, Yulin, Guangxi, China
🇨🇳The First People's Hospital of Yulin, Yulin, Guangxi, China
Brain Aneurysms: Utility of Cisternal Urokinase Irrigation
- First Posted Date
- 2021-03-11
- Last Posted Date
- 2021-03-11
- Lead Sponsor
- University of Valencia
- Target Recruit Count
- 247
- Registration Number
- NCT04792944
- Locations
- 🇪🇸
Hospital General Universitario de Valencia, Valencia, Spain
Intravenous Thrombolysis Registry for Acute Ischemic Stroke in China
- First Posted Date
- 2019-06-25
- Last Posted Date
- 2019-06-25
- Lead Sponsor
- General Hospital of Shenyang Military Region
- Registration Number
- NCT03997292
- Locations
- 🇨🇳
General Hospital of Shenyang Military Region, Shenyang, Liaoning, China
Intravenous Thrombolysis Registry for Chinese Ischemic Stroke Within 4.5 h Onset
- First Posted Date
- 2016-08-03
- Last Posted Date
- 2019-12-17
- Lead Sponsor
- General Hospital of Shenyang Military Region
- Target Recruit Count
- 4000
- Registration Number
- NCT02854592
- Locations
- 🇨🇳
General Hospital of ShenYang Military Region, ShenYang, China
Study of a Novel Thrombectomy Device to Treat Acute Iliofemoral Deep Venous Thrombosis
- First Posted Date
- 2015-04-13
- Last Posted Date
- 2017-01-18
- Lead Sponsor
- Xuzhou Medical University
- Target Recruit Count
- 40
- Registration Number
- NCT02414802
- Locations
- 🇨🇳
Department of Interventional Radiology and Vascular Surgery, the Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China
Safety and Efficacy Study of Urokinase for the Treatment of Diabetic Foot Syndrome and Critical Limb Ischemia
- First Posted Date
- 2012-07-11
- Last Posted Date
- 2014-04-07
- Lead Sponsor
- GWT-TUD GmbH
- Target Recruit Count
- 34
- Registration Number
- NCT01638585
- Locations
- 🇩🇪
Städtisches Krankenhaus DD-Neustadt, Dresden, Germany
🇩🇪Klinikum Westfalen/Klinikum am Park, Lünen, Germany
🇩🇪Vivantes Klinikum im Friedrichshain, Berlin, Germany
Local Thrombolytics Before Thrombectomy in STEMI
- First Posted Date
- 2012-04-02
- Last Posted Date
- 2020-04-08
- Lead Sponsor
- University of Roma La Sapienza
- Target Recruit Count
- 100
- Registration Number
- NCT01568931
Intrapleural Urokinase for Retained Hemothorax
- First Posted Date
- 2010-05-31
- Last Posted Date
- 2010-05-31
- Lead Sponsor
- National Taiwan University Hospital
- Target Recruit Count
- 32
- Registration Number
- NCT01134237
- Locations
- 🇨🇳
Chin-Chih Chang, Taipei, Taiwan
Recombinant Streptokinase Versus Urokinase in Pulmonary Embolism in China (RESUPEC)
- Conditions
- Interventions
- First Posted Date
- 2009-08-31
- Last Posted Date
- 2009-09-01
- Lead Sponsor
- Beijing Chao Yang Hospital
- Target Recruit Count
- 83
- Registration Number
- NCT00968929
- Locations
- 🇨🇳
The General Hospital of Shenyang Military Command, Shenyang, Liaoning, China
🇨🇳Shenzhen People's Hospital, Shenzhen, Guangdong, China
🇨🇳Guangdong Institute of Respiratory Disease, Guangzhou Medical University,, Guangzhou, Guangdong, China
Drug Development Updates
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