Norepinephrine
- Generic Name
- Norepinephrine
- Brand Names
- Levophed
- Drug Type
- Small Molecule
- Chemical Formula
- C8H11NO3
- CAS Number
- 51-41-2
- Unique Ingredient Identifier
- X4W3ENH1CV
- Background
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a symp...
- Indication
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
- Associated Conditions
- Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
- Associated Therapies
- -
Early Neurovascular Adaptations in Aging Women
- Conditions
- Interventions
- First Posted Date
- 2024-07-25
- Last Posted Date
- 2024-10-01
- Lead Sponsor
- University of Missouri-Columbia
- Target Recruit Count
- 64
- Registration Number
- NCT06520982
- Locations
- 🇺🇸
University of Missouri-Columbia, Columbia, Missouri, United States
Epinephrine Vs Norepinephrine Infusion During Caesarean Delivery
- Conditions
- Interventions
- First Posted Date
- 2024-07-22
- Last Posted Date
- 2024-07-22
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 212
- Registration Number
- NCT06512402
- Locations
- 🇪🇬
Cairo University, Cairo, Egypt
Norepinephrine and Phenylephrine for Spinal Anesthesia-induced Hypotension.
- Conditions
- Interventions
- First Posted Date
- 2024-07-18
- Last Posted Date
- 2024-07-18
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Target Recruit Count
- 2000
- Registration Number
- NCT06508359
Norepinephrine on Maternal Hypotension After Combined Lumbar and Epidural Anaesthesia
- First Posted Date
- 2024-07-12
- Last Posted Date
- 2024-07-12
- Lead Sponsor
- The Third People's Hospital of Bengbu
- Target Recruit Count
- 100
- Registration Number
- NCT06498115
- Locations
- 🇨🇳
The Third People's Hospital of Bengbu, Bengbu, Anhui, China
Management of Postspinal Anesthesia Hypotension During Elective Cesarean Section: Baby Norepinephrine Versus Ephedrine
- Conditions
- Interventions
- First Posted Date
- 2024-07-12
- Last Posted Date
- 2024-10-23
- Lead Sponsor
- Hopital Charles Nicolle
- Target Recruit Count
- 126
- Registration Number
- NCT06498076
- Locations
- 🇹🇳
Charles Nicolle Hospital, Tunis, Tunisia
Leg Wrapping and Norepinephrine for Prevention of Post Spinal Hypotension in C.S
- Conditions
- Interventions
- First Posted Date
- 2024-07-11
- Last Posted Date
- 2024-07-11
- Lead Sponsor
- Fayoum University
- Target Recruit Count
- 168
- Registration Number
- NCT06496061
- Locations
- 🇪🇬
Fayoum University hospital, Madīnat Al Fayyūm, Faiyum Governorate, Egypt
Dobutamine for Management of Surgical Patients with Septic Shock
- Conditions
- Interventions
- First Posted Date
- 2024-06-17
- Last Posted Date
- 2024-12-04
- Lead Sponsor
- First Affiliated Hospital of Zhejiang University
- Target Recruit Count
- 584
- Registration Number
- NCT06462313
- Locations
- 🇨🇳
The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock
- First Posted Date
- 2024-06-17
- Last Posted Date
- 2024-06-20
- Lead Sponsor
- Indonesia University
- Target Recruit Count
- 42
- Registration Number
- NCT06461390
- Locations
- 🇮🇩
Cipto Mangunkusumo Hospital, Jakarta Pusat, DKI Jakarta, Indonesia
Low-dose Arginine-vasopressin Supplementation on Post-transplant Acute Kidney Injury After Liver Transplantation (AVENIR Trial)
- Conditions
- Interventions
- First Posted Date
- 2024-04-03
- Last Posted Date
- 2024-06-03
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 304
- Registration Number
- NCT06344442
- Locations
- 🇫🇷
URC Lariboisière-Fernand Widal-saint Louis, Paris, France
Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study
- Conditions
- Interventions
- First Posted Date
- 2024-02-29
- Last Posted Date
- 2024-04-12
- Target Recruit Count
- 24
- Registration Number
- NCT06285396
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Drug Development Updates
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