DeepMed Research

Norepinephrine

Generic Name: Norepinephrine

Brand Names: Levophed

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₁NO_₃

CAS Number: 51-41-2

Unique Ingredient Identifier: X4W3ENH1CV

Background: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Indication: Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Associated Conditions: Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension

Clinical Trials

Vasopressor Outcomes in Spine Surgery

Early Phase 1

Recruiting

Conditions: Hypotension

Interventions: Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2023-09-25

Last Posted Date: 2025-01-03

Lead Sponsor: University of Texas Southwestern Medical Center

Target Recruit Count: 120

Registration Number: NCT06053398

Locations: 🇺🇸
Clements University Hospital at Dallas, Dallas, Texas, United States

Norepinephrine Prevent Post-induction Hypotension in High-risk Patients

Phase 4

Not yet recruiting

Conditions: Anesthesia
Blood Pressure
Norepinephrine

Interventions: Drug: Norepinephrine Hydrochloride
Drug: Placebo

First Posted Date: 2023-09-08

Last Posted Date: 2023-09-08

Lead Sponsor: First Affiliated Hospital of Kunming Medical University

Target Recruit Count: 180

Registration Number: NCT06028256

Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences

Phase 4

Suspended

Conditions: Vasoconstriction
Vasodilation

Interventions: Drug: Norepinephrine Bitartrate
Drug: Phenylephrine Hydrochloride
Drug: Phentolamine Mesylate
Drug: Propranolol Hydrochloride
Drug: Isoproterenol Hydrochloride

First Posted Date: 2023-08-18

Last Posted Date: 2024-10-09

Lead Sponsor: University of Alberta

Target Recruit Count: 30

Registration Number: NCT05997732

Locations: 🇨🇦
University of Alberta, Edmonton, Alberta, Canada

Hypotension Prediction Index vs Norepinephrine Infusion for Prevention of Spinal Hypotension for Cesarean Delivery

Phase 4

Not yet recruiting

Conditions: Hypotension During Surgery
Hypotension Drug-Induced

Interventions: Device: Hypotension Prediction Index
Drug: Norepinephrine

First Posted Date: 2023-08-01

Last Posted Date: 2023-08-03

Lead Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Target Recruit Count: 150

Registration Number: NCT05970770

Early Initiated Vasopressor Therapy in the Emergency Department

Phase 3

Recruiting

Conditions: Shock
Hypovolemic Shock
Hypovolemic
Shock, Septic
Hypovolemia
Hypotension
Hypotension and Shock
Hypotension Symptomatic

Interventions: Drug: Noradrenaline

First Posted Date: 2023-07-05

Last Posted Date: 2025-04-09

Lead Sponsor: Odense University Hospital

Target Recruit Count: 320

Registration Number: NCT05931601

Locations: 🇩🇰
Bispebjerg Hospital, Copenhagen, Denmark
🇩🇰
Esbjerg Hospital, Esbjerg, Denmark
🇩🇰
Gødstrup Regional Hospital, Herning, Denmark

and more 2 locations

Norepinephrine Weaning Guided by the Hypotension Prediction Index in Vasoplegic Shock After Cardiac Surgery

Not Applicable

Recruiting

Conditions: Norepinephrine
Vasoplegia
Surgery
Shock

Interventions: Drug: norepinephrine weaning protocol
Drug: norepinephrine weaning protocol and guided by the HPI

First Posted Date: 2023-06-28

Last Posted Date: 2024-07-03

Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Target Recruit Count: 142

Registration Number: NCT05922982

Locations: 🇫🇷
CHU Amiens Picardie, Amiens, France

The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized Therapy for Shock Patients

Phase 4

Recruiting

Conditions: Septic Shock

Interventions: Drug: norepinephrine+vasopressin
Drug: Norepinephrine

First Posted Date: 2023-06-02

Last Posted Date: 2023-06-02

Lead Sponsor: Peking Union Medical College Hospital

Target Recruit Count: 60

Registration Number: NCT05886192

Locations: 🇨🇳
Peking Union Medical College Hospital, Beijing, Beijing, China

Early Administration of Norepinephrine in Sepsis

Phase 4

Recruiting

Conditions: Sepsis, Severe

Interventions: Drug: Norepinephrine Bitartrate
Other: Placebo

First Posted Date: 2023-05-01

Last Posted Date: 2024-12-04

Lead Sponsor: Tunis University

Target Recruit Count: 200

Registration Number: NCT05836272

Locations: 🇹🇳
intensive care unit of the University Hospital Center La Rabta, Tunis, Tunisia

Effect of Preemptive Low Dose Norepinephrine Infusion on Intraoperative Hemodynamic Stability and Postoperative Outcomes in Patients Undergoing Brain Tumor Resection With a Craniotomy

Not Applicable

Not yet recruiting

Conditions: Brain Tumor

Interventions: Drug: norepinephrine

First Posted Date: 2023-04-18

Last Posted Date: 2023-04-18

Lead Sponsor: Yonsei University

Target Recruit Count: 70

Registration Number: NCT05814601

Locations: 🇰🇷
Yonsei University College of Medicine, Seoul, Korea, Republic of

The Impact of Early Norepinephrine Administration on Outcomes of Patients With Sepsis-induced Hypotension

Not Applicable

Completed

Conditions: Sepsis
Norepinephrine
Hypotension

Interventions: Drug: Crystalloid
Drug: noradrenaline

First Posted Date: 2023-03-17

Last Posted Date: 2023-03-24

Lead Sponsor: Tanta University

Target Recruit Count: 64

Registration Number: NCT05774054

Locations: 🇪🇬
Faculty of medicine, Tanta university, Tanta, El Gharbyia, Egypt

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