Norepinephrine

Generic Name: Norepinephrine

Brand Names: Levophed

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₁NO_₃

CAS Number: 51-41-2

Unique Ingredient Identifier: X4W3ENH1CV

Background: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a symp...

Indication: Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Associated Conditions: Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension

Associated Therapies: -

Clinical Trials

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

Early Phase 1

Recruiting

Conditions: Obesity
Vasodilation
Healthy

Interventions: Drug: Propranolol Hydrochloride
Drug: Isoproterenol
Drug: Phentolamine Mesylate
Drug: Norepinephrine

First Posted Date: 2022-02-02

Last Posted Date: 2024-02-20

Lead Sponsor: University of Missouri-Columbia

Target Recruit Count: 72

Registration Number: NCT05219799

Locations: 🇺🇸
University of Missouri, Columbia, Missouri, United States

Hot Flashes and Neurovascular Function in Women

Not Applicable

Recruiting

Conditions: Hot Flashes
Menopause
Vasomotor System; Labile

Interventions: Other: Sympathoexcitatory stressors
Drug: Sodium Nitroprusside
Drug: Acetylcholine
Drug: Terbutaline
Drug: Norepinephrine

First Posted Date: 2022-01-18

Last Posted Date: 2024-05-24

Lead Sponsor: Mayo Clinic

Target Recruit Count: 120

Registration Number: NCT05193968

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Early Vasopressors in Sepsis

Phase 3

Recruiting

Conditions: Sepsis

Interventions: Other: Balanced Crystalloid
Drug: Norepinephrine

First Posted Date: 2022-01-05

Last Posted Date: 2023-12-21

Lead Sponsor: NHS Greater Glasgow and Clyde

Target Recruit Count: 3286

Registration Number: NCT05179499

Locations: 🇬🇧
Fairfield General Hospital, Bury, United Kingdom
🇬🇧
Royal Derby Hospital, Derby, United Kingdom
🇬🇧
Glasgow Royal Infirmary, Glasgow, United Kingdom

and more 22 locations

Effects of Vasopressor on the Graft Blood Flow in TRAM

Not Applicable

Completed

Conditions: Flap Necrosis
Flap Ischemia
Blood Flow
Anastomotic Failure of Flap

Interventions: Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2021-09-20

Last Posted Date: 2023-05-03

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 20

Registration Number: NCT05049278

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of

Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension

Not Applicable

Completed

Conditions: Adverse Effect

Interventions: Drug: Norepinephrine
Drug: Phenylephrine

First Posted Date: 2021-09-05

Last Posted Date: 2023-01-05

Lead Sponsor: General Hospital of Ningxia Medical University

Target Recruit Count: 80

Registration Number: NCT05035888

Locations: 🇨🇳
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

Prophylactic Norepinephrine and Phenylephrine Infusion for Hemodynamic Effects in Patients With Preeclampsia

Not Applicable

Recruiting

Conditions: Hemodynamic Instability

Interventions: Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2021-09-05

Last Posted Date: 2024-02-02

Lead Sponsor: General Hospital of Ningxia Medical University

Target Recruit Count: 72

Registration Number: NCT05035498

Locations: 🇨🇳
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

The Potency of Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension

Not Applicable

Conditions: Adverse Effect

Interventions: Drug: Norepinephrine
Drug: Phenylephrine

First Posted Date: 2021-09-05

Last Posted Date: 2021-09-13

Lead Sponsor: General Hospital of Ningxia Medical University

Target Recruit Count: 80

Registration Number: NCT05035472

Maternal Cardiac Output Response to Rescue Norepinephrine and Phenylephrine Boluses in Patients With Severe Preeclampsia

Not Applicable

Completed

Conditions: Hemodynamic Instability

Interventions: Drug: Norepinephrine
Drug: Phenylephrine

First Posted Date: 2021-09-05

Last Posted Date: 2024-02-02

Lead Sponsor: General Hospital of Ningxia Medical University

Target Recruit Count: 40

Registration Number: NCT05035485

Locations: 🇨🇳
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation

Phase 3

Not yet recruiting

Conditions: Respiratory Failure
Critical Illness

Interventions: Drug: Noradrenaline

First Posted Date: 2021-08-20

Last Posted Date: 2023-11-21

Lead Sponsor: University of Turin, Italy

Target Recruit Count: 420

Registration Number: NCT05014581

Locations: 🇮🇹
University Hospital San Luigi Gonzaga, Orbassano, Turin, Italy
🇫🇷
CHU de Nantes, Nantes, France
🇮🇪
Galway University Hospitals, Galway, Ireland

Effect of Three Weight-adjusted Vasopressors for Elective Cesarean Delivery

Phase 4

Completed

Conditions: Cesarean Section Complications

Interventions: Drug: Phenylephrine
Drug: Norepinephrine
Drug: metaraminol

First Posted Date: 2021-08-05

Last Posted Date: 2021-12-30

Lead Sponsor: Xuzhou Medical University

Target Recruit Count: 78

Registration Number: NCT04991662

Locations: 🇨🇳
Department of Anesthesiology and Operating Room, Affiliated Hospital of Peking University People's Hospital, Peking, Beijing, China

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