Norepinephrine

Generic Name
Norepinephrine
Brand Names
Levophed
Drug Type
Small Molecule
Chemical Formula
C8H11NO3
CAS Number
51-41-2
Unique Ingredient Identifier
X4W3ENH1CV
Background

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Indication

Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Associated Conditions
Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
Associated Therapies
-
Clinical Trials
Related News

Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension

Not Applicable
Completed
Conditions
Adverse Effect
Interventions
Drug: Normal saline
Drug: Norepinephrine
First Posted Date
2020-02-17
Last Posted Date
2020-08-04
Lead Sponsor
General Hospital of Ningxia Medical University
Target Recruit Count
99
Registration Number
NCT04272567
Locations
🇨🇳

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

Blood PREssure Augmentation in Large-vessel Occlusion Stroke Study

First Posted Date
2020-01-06
Last Posted Date
2024-10-03
Lead Sponsor
Yale University
Target Recruit Count
40
Registration Number
NCT04218773
Locations
🇺🇸

Yale-New Haven Hospital, New Haven, Connecticut, United States

The Effect of Vasopressors on Cerebral Oxygentaion During Off Pump CABG

First Posted Date
2020-01-02
Last Posted Date
2022-05-09
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
90
Registration Number
NCT04214145
Locations
🇰🇷

Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea, Republic of

Norepinephrine Versus Phenylephrine for Preventing Spinal Anesthesia Induced Hypotension in Elderly

First Posted Date
2019-12-11
Last Posted Date
2021-09-01
Lead Sponsor
Kasr El Aini Hospital
Target Recruit Count
62
Registration Number
NCT04195321
Locations
🇪🇬

Kasr Alaini Hospital, Cairo, Egypt

Norepinephrine and Phenylephrine, Which Better for Elderly?

First Posted Date
2019-08-28
Last Posted Date
2019-10-08
Lead Sponsor
The Second Affiliated Hospital of Dalian Medical University
Target Recruit Count
100
Registration Number
NCT04067817
Locations
🇨🇳

The Second Hospital of Dalian Medical University, Dalian, Liaoning, China

Effects of Ephedrine, Phenylephrine, Norepinephrine and Vasopressin on Contractility of Human Myometrium and Umbilical Vessels: An In-vitro Study

First Posted Date
2019-08-12
Last Posted Date
2024-03-07
Lead Sponsor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Target Recruit Count
144
Registration Number
NCT04053478
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

Prophylactic Norepinephrine Infusion for Spinal Hypotension and Inferior Vena Cava Collapsibility Index

Not Applicable
Completed
Conditions
Adverse Effect
Interventions
Drug: normal saline
Drug: Norepinephrine
First Posted Date
2019-06-25
Last Posted Date
2020-02-17
Lead Sponsor
General Hospital of Ningxia Medical University
Target Recruit Count
195
Registration Number
NCT03997500
Locations
🇨🇳

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

Effect of Norepinephrine Infusion on Hepatic Blood Flow During Goal-directed Haemodynamic Therapy.

Phase 4
Completed
Conditions
General Anesthesia
Interventions
Drug: Norepinephrine
First Posted Date
2019-05-28
Last Posted Date
2022-12-09
Lead Sponsor
University Hospital, Ghent
Target Recruit Count
49
Registration Number
NCT03965117
Locations
🇧🇪

University Hospital Ghent, Gent, Oost-Vlaanderen, Belgium

Effect of Phenylephrine Versus Norepinephrine on Venous Return

First Posted Date
2019-03-13
Last Posted Date
2019-10-11
Lead Sponsor
Algemeen Ziekenhuis Maria Middelares
Target Recruit Count
40
Registration Number
NCT03872570
Locations
🇧🇪

General Hospital Maria Middelares, Ghent, Oost-Vlaanderen, Belgium

Hemodynamics During Induction of General Anesthesia After Prophylactic Ephedrine, Phenylephrine or Norepinephrine.

First Posted Date
2019-03-06
Last Posted Date
2024-10-04
Lead Sponsor
Helse Fonna
Target Recruit Count
128
Registration Number
NCT03864094
Locations
🇳🇴

Helse Fonna, Haugesund Sykehus, Haugesund, Norway

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