Ketotifen

Generic Name
Ketotifen
Brand Names
Alaway, Zaditen, Zaditor
Drug Type
Small Molecule
Chemical Formula
C19H19NOS
CAS Number
34580-13-7
Unique Ingredient Identifier
X49220T18G
Background

Ketotifen is a benzocycloheptathiophene derivative with potent antihistaminic and mast cell stabilizing properties. It has a similar structure to some other first-generation antihistamines such as cyproheptadine and azatadine.
...

Indication

Administered orally, ketotifen is indicated as an add-on medication in the chronic treatment of mild atopic asthma in children. It is also available as an over-the-counter ophthalmic solution which is indicated for the temporary prevention of itching of the eye due to allergic conjunctivitis.

Associated Conditions
Allergic Rhinitis (AR), Asthma, Allergic, Eye pruritus, Seasonal Allergic Conjunctivitis
Associated Therapies
-
Clinical Trials
Related News

Ketotifen in Non-Alcoholic Fatty Liver Disease Patients

Phase 4
Not yet recruiting
Conditions
Hepatic Disease
Interventions
Drug: Vitamin E
Drug: Ketotifen
First Posted Date
2022-11-15
Last Posted Date
2022-11-15
Lead Sponsor
Tanta University
Target Recruit Count
60
Registration Number
NCT05616442

Ketotifen as a Treatment for Vascular Leakage During Dengue Fever

First Posted Date
2016-02-04
Last Posted Date
2016-02-04
Lead Sponsor
National University Hospital, Singapore
Target Recruit Count
110
Registration Number
NCT02673840
Locations
🇸🇬

Singapore General Hospital, Singapore, Singapore

🇸🇬

National University Hospital (Investigational Medicine Unit), Singapore, Singapore

Ketotifen for Children With Functional Dyspepsia in Association With Duodenal Eosinophilia

Phase 3
Active, not recruiting
Conditions
Functional Dyspepsia
Interventions
Drug: Placebo
Drug: Ketotifen
First Posted Date
2015-06-29
Last Posted Date
2023-09-21
Lead Sponsor
Children's Mercy Hospital Kansas City
Target Recruit Count
40
Registration Number
NCT02484248
Locations
🇺🇸

The Children's Mercy Hospital, Kansas City, Missouri, United States

Investigations of Mechanisms and Treatment in Post-traumatic Joint Contractures

Phase 2
Completed
Conditions
Joint Contractures
Interventions
Drug: Placebo
Drug: Ketotifen
First Posted Date
2013-07-17
Last Posted Date
2018-03-27
Lead Sponsor
University of Calgary
Target Recruit Count
152
Registration Number
NCT01902017
Locations
🇨🇦

Peter Lougheed Centre, Calgary, Alberta, Canada

🇨🇦

Foothills Medical Centre, Calgary, Alberta, Canada

🇨🇦

South Health Campus, Calgary, Alberta, Canada

Pilot Study to Evaluate the Effect of Ketotifen on the Adverse Events Associated With Peanut Desensitization

Phase 2
Conditions
Peanut Allergies in Children
Interventions
Drug: Ketotifen
First Posted Date
2012-06-21
Last Posted Date
2012-06-21
Lead Sponsor
Gordon Sussman Clinical Research
Target Recruit Count
6
Registration Number
NCT01625715
Locations
🇨🇦

GSCRI, Toronto, Ontario, Canada

Novel Use of (Oral) Ketotifen for the Treatment of Fibromyalgia: A Pilot Study

Phase 3
Completed
Conditions
Fibromyalgia
Interventions
Drug: Placebo (Sugar Pill)
Drug: Ketotifen
First Posted Date
2012-03-14
Last Posted Date
2016-11-17
Lead Sponsor
Indiana University
Target Recruit Count
51
Registration Number
NCT01553318
Locations
🇺🇸

IU Clincial Research Center for Pain and Fibromyalgia, Indianapolis, Indiana, United States

Ketotifen/Naphazoline Ophthalmic Solution in the Conjunctival Allergen Challenge Model of Acute Allergic Conjunctivitis.

First Posted Date
2008-10-09
Last Posted Date
2020-10-27
Lead Sponsor
Bausch & Lomb Incorporated
Target Recruit Count
141
Registration Number
NCT00770133
Locations
🇺🇸

Ophthalmic Research Consultants, Inc., North Andover, Massachusetts, United States

Ketotifen/Naphazoline Ophthalmic Solution in the Conjunctival Allergen Challenge Model of Allergic Conjunctivitis.

First Posted Date
2008-10-09
Last Posted Date
2024-04-03
Lead Sponsor
Bausch & Lomb Incorporated
Target Recruit Count
144
Registration Number
NCT00769886
Locations
🇺🇸

Ophthalmic Research Consultants, Inc., North Andover, Massachusetts, United States

Efficacy and Safety of Cetirizine Tablets Versus Ketotifen Dry Syrup in Children With Perennial Allergic Rhinitis

Phase 3
Completed
Conditions
Rhinitis, Allergic, Perennial
First Posted Date
2008-03-20
Last Posted Date
2009-09-04
Lead Sponsor
UCB Pharma
Target Recruit Count
149
Registration Number
NCT00639587

Ketotifen Ophthalmic Solution With Emedastine in Patients With Seasonal Allergic Conjunctivitis

Phase 4
Completed
Conditions
Seasonal Allergic Conjunctivitis
First Posted Date
2005-08-23
Last Posted Date
2011-11-17
Lead Sponsor
Novartis
Target Recruit Count
229
Registration Number
NCT00133627
Locations
🇨🇳

Hospital of Shanghai Medical University, Shanghai, China

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