Amifampridine
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Amifampridine is a voltage gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome.
Amifampridine is a voltage gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome.
Amifampridine is a symptomatic treatment that increases acetylcholine concentrations at the neuromuscular junction. It selectively blocks presynaptic fast voltage-gated potassium channels, thereby prolonging cell membrane depolarization and action potential, and augmenting calcium transport into the nerve endings. Increased intracellular calcium enhances the exocytosis of acetylcholine-containing vesicles and enhances impulse transmission at central, autonomic, and neuromuscular synapses . Amifampridine improves muscle strength and resting compound muscle action potential (CMAP) amplitudes with an overall weighted mean difference of 1.69 mV .
用于治疗6岁及以上的成人和儿童患者的一种罕见病自身免疫疾病兰伯特-伊顿（Lambert Eaton）肌无力综合征（LEMS）。LEMS最常见的表现是肌无力，容易疲劳，可导致行走及爬楼梯困难。
共 1 项相关疾病
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