Lithium carbonate

Generic Name
Lithium carbonate
Brand Names
Carbolith, Lithane, Lithmax, Lithobid
Drug Type
Small Molecule
Chemical Formula
CLi2O3
CAS Number
554-13-2
Unique Ingredient Identifier
2BMD2GNA4V
Background

Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects.

Indication

Lithium carbonate is indicated as a monotherapy for the treatment of acute manic and mixed episodes associated with bipolar 1 disorder in patients ≥7 years of age. It is also indicated as a maintenance treatment for bipolar 1 disorder in patients ≥7 years of age.

Associated Conditions
Bipolar 1 Disorder, Mixed manic depressive episode, Acute Manic episode
Associated Therapies
-
Clinical Trials
Related News

A Study of Lithium and Enlicitide in Healthy Adult Participants (MK-0616-034)

Phase 1
Not yet recruiting
Conditions
Healthy
Interventions
Drug: lithium carbonate
Drug: enlicitide
First Posted Date
2024-12-06
Last Posted Date
2024-12-13
Lead Sponsor
Merck Sharp & Dohme LLC
Target Recruit Count
16
Registration Number
NCT06719544

Effects of Lithium on Suicide Prevention in Adolescents and Young Adults With Bipolar Disorder in China

First Posted Date
2024-05-22
Last Posted Date
2024-05-22
Lead Sponsor
Peking University
Target Recruit Count
600
Registration Number
NCT06424613
Locations
🇨🇳

Mental Health Institute of Peking University, Beijing, Beijing, China

Lithium Versus Lamotrigine in Bipolar Disorder, Type II

Phase 4
Recruiting
Conditions
Bipolar II Disorder
Interventions
Drug: Lithium Carbonate
Drug: Lamotrigine
First Posted Date
2023-12-28
Last Posted Date
2024-06-07
Lead Sponsor
Mental Health Services in the Capital Region, Denmark
Target Recruit Count
200
Registration Number
NCT06184581
Locations
🇩🇰

Psychiatric Center Copenhagen, Copenhagen, Denmark

Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)

First Posted Date
2023-04-18
Last Posted Date
2023-08-14
Lead Sponsor
First Affiliated Hospital of Chongqing Medical University
Target Recruit Count
520
Registration Number
NCT05814640
Locations
🇨🇳

The First Affiliated Hospital of Chongqing Medical University, Chongqing, Province, China

The CHAMP-study: The CHemopreventive Effect of Lithium in Familial AdenoMatous Polyposis

Phase 2
Completed
Conditions
Familial Adenomatous Polyposis
Interventions
Drug: Lithium Carbonate
First Posted Date
2022-06-02
Last Posted Date
2024-10-04
Lead Sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Target Recruit Count
12
Registration Number
NCT05402891
Locations
🇳🇱

Academic Medical Centre, Amsterdam, Noord-Holland, Netherlands

Efficacy of Lithium Against Chemotherapy Induced Neutropenia in Breast Cancer Patients

Phase 3
Completed
Conditions
Neutropenia
Interventions
Drug: Lithium Carbonate
First Posted Date
2022-02-03
Last Posted Date
2022-10-21
Lead Sponsor
Al-Azhar University
Target Recruit Count
50
Registration Number
NCT05221593
Locations
🇪🇬

Al-Azhar University, Cairo, Non-US/Non-Canadian, Egypt

A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction

First Posted Date
2021-11-18
Last Posted Date
2024-01-25
Lead Sponsor
Negovsky Reanimatology Research Institute
Target Recruit Count
500
Registration Number
NCT05126238
Locations
🇷🇺

Vishnevsky Center of Surgery, Moscow, Russian Federation

🇷🇺

Demikhov Municipal Clinical Hospital 68, Moscow, Russian Federation

Effect of Lithium in Patients With Autism Spectrum Disorder and Phelan-McDermid Syndrome (SHANK3 Haploinsufficiency)

Phase 3
Active, not recruiting
Conditions
Autism Spectrum Disorder
Interventions
Drug: Placebo
Drug: Lithium Carbonate
First Posted Date
2020-11-10
Last Posted Date
2024-05-28
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
22
Registration Number
NCT04623398
Locations
🇫🇷

Hôpital Robert Debré, Paris, France

Effect of Regulated Add -on Sodium Chloride Intake on Stabilization of Serum Lithium Concentration in Bipolar Disorder

First Posted Date
2020-01-10
Last Posted Date
2022-01-25
Lead Sponsor
All India Institute of Medical Sciences, Bhubaneswar
Target Recruit Count
60
Registration Number
NCT04222816
Locations
🇮🇳

Aiims Bhubaneswar, Khorda, Orissa, India

Study of Lithium Carbonate to Treat Niemann-Pick Type C1 Disease

Early Phase 1
Conditions
Niemann-Pick Disease, Type C1
Interventions
Drug: Lithium Carbonate
First Posted Date
2017-06-28
Last Posted Date
2019-09-24
Lead Sponsor
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Target Recruit Count
18
Registration Number
NCT03201627
Locations
🇨🇳

Xin Hua Hospital, Shanghai, Shanghai, China

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