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Colistin

Generic Name
Colistin
Brand Names
Cortisporin-TC
Drug Type
Small Molecule
Chemical Formula
C52H98N16O13
CAS Number
1066-17-7
Unique Ingredient Identifier
Z67X93HJG1
Background

Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.

Indication

For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.

Associated Conditions
Ear infection bacterial, External ear infection NOS
Clinical Trials
Related News

Colistin Intravenous Administration in Critically Ill Patients Suffering From Hospital Infections Caused by Multi-antibiotic-resistant Germs.

Phase 4
Conditions
Multi-antibiotic Resistance
Critically Ill
Hospital Infection
Interventions
First Posted Date
2021-08-06
Last Posted Date
2021-08-06
Lead Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Target Recruit Count
20
Registration Number
NCT04995133
Locations
🇮🇹

Fondazione Policlinico A.Gemelli IRCSS, Roma, Italia, Italy

Comparative Clinical Study Between Colistin-Tigecycline Combined Therapy Versus Colistin-Meropenem Combined Therapy in Treatment of Blood Stream Infections With Multidrug-Resistant Klebsiella Pneumoniae

Phase 4
Conditions
Treatment of Blood Stream Infections Due to Multidrug-Resistant Klebsiella Pneumoniae
Interventions
First Posted Date
2020-07-28
Last Posted Date
2020-07-29
Lead Sponsor
Al-Azhar University
Target Recruit Count
60
Registration Number
NCT04489459
Locations
🇪🇬

Qasr El Ainy, Cairo, Egypt

Nebulized Colistin for Gram Negative VAP Prevention.

Not Applicable
Conditions
Pneumonia, Ventilator-associated
Gram-Negative Pneumonia
Interventions
First Posted Date
2019-12-23
Last Posted Date
2019-12-23
Lead Sponsor
University of Thessaly
Target Recruit Count
152
Registration Number
NCT04208945
Locations
🇬🇷

Evangelismos University Hospital of Athens, Athens, Greece

🇬🇷

General Hospital of Volos Thessaly, Volos, Thessaly, Greece

🇬🇷

University Hospital of Larisa, Larisa, Greece/Thessaly, Greece

A Randomized Controlled Trial Comparing Imipenem and Tigecycline Versus Imipenem and Tigecycline With GM-CSF for the Management of Spontaneous Bacterial Peritonitis Presenting With Septic Shock.

Not Applicable
Conditions
Spontaneous Bacterial Peritonitis
Interventions
Drug: GMCSF
First Posted Date
2019-12-23
Last Posted Date
2021-02-16
Lead Sponsor
Institute of Liver and Biliary Sciences, India
Target Recruit Count
90
Registration Number
NCT04208763
Locations
🇮🇳

Institute of Liver and Biliary Sciences, New Delhi, Delhi, India

Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-calcoaceticus Complex

Phase 3
Completed
Conditions
Hospital-acquired Bacterial Pneumonia
Acinetobacter Baumannii-calcoaceticus Complex
Bacteremia
Ventilator-associated Bacterial Pneumonia
Colistin Resistant ABC
Interventions
Drug: Imipenem/Cilastatin 500 mg/500 mg
First Posted Date
2019-03-28
Last Posted Date
2023-02-01
Lead Sponsor
Entasis Therapeutics
Target Recruit Count
207
Registration Number
NCT03894046
Locations
🇹🇷

Entasis Research Site 2, Ankara, Turkey

🇷🇺

Entasis Research Site 3, Novosibirsk, Russian Federation

🇹🇷

Entasis Research Site, Trabzon, Turkey

and more 1 locations

The Effect of Colistin Inhalation on Ventilator Associated Pneumonia

Phase 2
Completed
Conditions
Ventilator Associated Pneumonia
Interventions
Drug: Carbapenem + Aminoglycoside/ Quinolone
First Posted Date
2018-08-09
Last Posted Date
2018-08-09
Lead Sponsor
Nourhan Hassan Osama Thuraya Mohamed
Target Recruit Count
40
Registration Number
NCT03622450

Colistin-rifampin Combination and Colistin Monotherapy in Extensively Drug-resistant Acinetobacter Baumannii

Not Applicable
Completed
Conditions
Rifampin
Acinetobacter Infections
Colistin
Interventions
First Posted Date
2018-08-09
Last Posted Date
2018-08-09
Lead Sponsor
Gangnam Severance Hospital
Target Recruit Count
9
Registration Number
NCT03622918

Combined Dry Powder Tobramycin and Nebulized Colistin Inhalation in CF Patients

Phase 3
Completed
Conditions
Cystic Fibrosis With Pulmonary Manifestations
Interventions
First Posted Date
2017-11-14
Last Posted Date
2017-11-14
Lead Sponsor
University Hospital Tuebingen
Target Recruit Count
26
Registration Number
NCT03341741

IV Colistin for Pulmonary Exacerbations: Improving Safety and Efficacy

Phase 4
Completed
Conditions
Cystic Fibrosis
Interventions
First Posted Date
2016-09-29
Last Posted Date
2023-04-21
Lead Sponsor
National Jewish Health
Target Recruit Count
51
Registration Number
NCT02918409
Locations
🇺🇸

National Jewish Health, Denver, Colorado, United States

Nebulized and Intravenous Colistin in Ventilator Associated-pneumonia

Phase 3
Terminated
Conditions
Ventilator-associated Pneumonia
Interventions
Drug: Intravenous placebo
Drug: Nebulized placebo
First Posted Date
2016-09-20
Last Posted Date
2018-08-13
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
7
Registration Number
NCT02906722
Locations
🇫🇷

Hôpital Pitié-Salpêtriere, Paris, France

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