Colistin
- Generic Name
- Colistin
- Brand Names
- Cortisporin-TC
- Drug Type
- Small Molecule
- Chemical Formula
- C52H98N16O13
- CAS Number
- 1066-17-7
- Unique Ingredient Identifier
- Z67X93HJG1
- Background
Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.
- Indication
For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.
- Associated Conditions
- Ear infection bacterial, External ear infection NOS
Aerosolized Plus Intravenous vs. Intravenous Colistin for VAP Due to Pandrugs-resistant A. Baumannii in Neonates
- Conditions
- Pneumonia, Ventilator-AssociatedColistin Adverse ReactionInfection Due to Multidrug Resistant AcinetobacterInfection Resistant to Multiple Drugs
- Interventions
- Drug: Aerosolized plus intravenous colistin
- First Posted Date
- 2016-06-20
- Last Posted Date
- 2018-08-02
- Lead Sponsor
- Hat Yai Medical Education Center
- Target Recruit Count
- 204
- Registration Number
- NCT02806141
- Locations
- 🇹🇭
Narongsak Nakwan, Hat Yai, Songkhla, Thailand
Effect of Aerosolised Colistin in Ventilator Associated Pneumonia
- Conditions
- Pneumonia, Ventilator-Associated
- Interventions
- First Posted Date
- 2016-02-17
- Last Posted Date
- 2016-02-17
- Lead Sponsor
- Tunis University
- Target Recruit Count
- 133
- Registration Number
- NCT02683603
- Locations
- 🇹🇳
intensive care unit of the University Hospital Center La Rabta, Tunis, Tunisia
Therapy of Ventilator-associated Tracheobronchitis Caused by Gram Negative Bacteria With Nebulized Colistin
- First Posted Date
- 2015-12-02
- Last Posted Date
- 2015-12-02
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 62
- Registration Number
- NCT02619786
Impact of Treatment With Colistin on Mortality Bacteremia Multiresistant Acinetobacter Baumannii Sensitive Colistin in Patients Critical
- Conditions
- Acinetobacter Infections
- First Posted Date
- 2015-10-09
- Last Posted Date
- 2015-10-09
- Lead Sponsor
- Maimónides Biomedical Research Institute of Córdoba
- Target Recruit Count
- 113
- Registration Number
- NCT02573064
Eradication of Antibiotic-resistant Bacteria Through Antibiotics and Fecal Bacteriotherapy
- Conditions
- Intestinal Colonization With Multidrug-resistant Bacteria
- Interventions
- First Posted Date
- 2015-06-16
- Last Posted Date
- 2017-12-07
- Lead Sponsor
- Stephen Harbarth
- Target Recruit Count
- 39
- Registration Number
- NCT02472600
- Locations
- 🇫🇷
Assistance Publique-Hôpitaux de Paris, Hôpital Beaujon, Clichy, France
🇳🇱Universitair Medisch Centrum Utrecht,, Utrecht, Netherlands
🇨🇭Geneva University Hospitals, Geneva, Switzerland
Optimization Dose Study on Pharmacokinetics and Pharmacodynamics of Colistin in Critically Ill Patients
- Conditions
- Critical Illness
- Interventions
- First Posted Date
- 2015-04-03
- Last Posted Date
- 2016-02-03
- Target Recruit Count
- 20
- Registration Number
- NCT02408185
- Locations
- 🇪🇸
Hospital Universitario Virgen del Rocío, Seville, Spain
Safety and Efficacy Study of High Dose Colistin
- Conditions
- Infectious Diseases
- Interventions
- First Posted Date
- 2014-06-13
- Last Posted Date
- 2015-04-01
- Lead Sponsor
- King Saud Medical City
- Target Recruit Count
- 330
- Registration Number
- NCT02162966
- Locations
- 🇸🇦
King Saud Medical City, Riyadh, Saudi Arabia
Efficacy and Mortality of a Loading Dose of Colistin in Critical Ill Patients
- First Posted Date
- 2014-04-21
- Last Posted Date
- 2018-03-13
- Lead Sponsor
- Hospital Barros Luco Trudeau
- Target Recruit Count
- 200
- Registration Number
- NCT02117986
- Locations
- 🇨🇱
Hospital Barros Luco Trudeau, Santiago, Region Metropolitana, Chile
🇨🇱Hospital de Puerto Montt, Puerto Montt, Chile
Colistin Pharmacokinetics in Continuous Renal Replacement Therapy
- First Posted Date
- 2014-03-07
- Last Posted Date
- 2014-03-07
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 10
- Registration Number
- NCT02081560
- Locations
- 🇨🇭
University Hospital of Zurich, Dept. of Pharmacology and Toxicology, Zurich, ZH, Switzerland
A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE)
- Conditions
- Bloodstream Infections (BSI) Due to CREHospital-Acquired Bacterial Pneumonia (HABP) Due to CREVentilator-Associated Bacterial Pneumonia (VABP) Due to CREComplicated Urinary Tract Infection (cUTI) Due to CREAcute Pyelonephritis (AP) Due to CRE
- Interventions
- Drug: antibiotic of Investigator's choice
- First Posted Date
- 2013-10-28
- Last Posted Date
- 2018-10-16
- Lead Sponsor
- Achaogen, Inc.
- Target Recruit Count
- 69
- Registration Number
- NCT01970371
Drug Development Updates
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