Chlorpheniramine

Overview

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.

Indication

For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.

Associated Conditions

Allergic Conjunctivitis (AC)
Allergic Contact Dermatitis
Allergic Reaction
Allergic Rhinitis (AR)
Allergic cough
Allergies caused by Serum
Allergy to Tree Pollen
Allergy to vaccine
Angioneurotic Edema
Asthma
Bronchial Asthma
Bronchitis
Common Cold
Conjunctival congestion
Conjunctivitis
Cough
Cough caused by Common Cold
Coughing caused by Flu caused by Influenza
Drug Allergy
Epiphora
Eye allergy
Fever
Flu caused by Influenza
Food Allergy
Headache
Headache caused by Allergies
House Dust Mite Allergy
Itching of the nose
Itching of the throat
Migraine
Nasal Congestion
Nasal Congestion caused by Common Cold
Productive cough
Pruritus
Rash
Rhinorrhoea
Seasonal Allergic Conjunctivitis
Sinus Congestion
Sinusitis
Sneezing
Transfusion Reactions
Upper Respiratory Tract Infection
Upper respiratory tract congestion
Upper respiratory tract hypersensitivity reaction, site unspecified
Urticaria
Vasomotor Rhinitis
Acute Rhinitis
Allergic purpura
Conjunctival hyperemia
Dry cough
Excess mucus or phlegm
Itchy throat
Mild bacterial upper respiratory tract infections
Ocular hyperemia
Throat inflammation
Upper respiratory symptoms
Watery itchy eyes

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Efficacy of Placebo Versus Chlorpheniramine for the Prevention of Allergic Transfusion Reactions.	2020/12/30	NCT04688736	Phase 2	Recruiting	Institute of Hematology & Blood Diseases Hospital, China
Effect of the Antihistamine Injection to Prevent Paradoxical Reaction During Sedative Endoscopy	2019/05/07	NCT03940391	Not Applicable	UNKNOWN	Seoul National University Hospital
Dose-Ranging Study of Mometasone Furoate (MK-0887/SCH 032088) Nasal Spray in the Treatment of Children (Ages 6-11) With Seasonal Allergic Rhinitis (C95-161)	2019/03/19	NCT03879772	Phase 3	Completed	Organon and Co
Anti-histamines Promote Electroacupuncture Analgesia: Basic and Clinical Research	2019/01/15	NCT03805035	Not Applicable	Completed	China Medical University Hospital
Effect of Anti-histamine in Prevention Systolic Hypotension After Protamine	2018/07/11	NCT03583567	Phase 4	Completed	Mahidol University
Clinical Trial of the Safety and Efficacy of SP160412 in the Temporary Relief of Mild to Moderate Sunburn	2017/11/06	NCT03332524	Phase 2	Terminated	Sephoris Pharmaceuticals LLC
Exploratory Study for Allergy Relief Onset	2016/03/29	NCT02722083	Phase 2	Terminated	Bayer
A Multicenter Study to Determine the Depth and Duration of Hepatitis B Surface Antigen (HBsAg) Reduction After Single or Multiple Doses of ARC-520, in Combination With Entecavir in Patients With Chronic Hepatitis B Virus (HBV) Infection	2014/02/19	NCT02065336	Phase 2	Terminated	Arrowhead Pharmaceuticals
Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects	2010/09/27	NCT01209455	Not Applicable	Completed	University of Edinburgh
Fed Study of Chlorpheniramine Polistirex and Hydrocodone Polistirex Capsules and Tussionex® Pennkinetic® Extended Release Oral Suspension	2009/03/02	NCT00853190	Phase 1	Completed	Mallinckrodt

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release	Tris Pharma Inc	27808-086	ORAL	8 mg in 5 mL	5/31/2021
Advil Allergy and Congestion Relief	Haleon US Holdings LLC	0573-0196	ORAL	4 mg in 1 1	4/9/2025
Bactimicina Childrens Cough and Cold	DLC Laboratories, Inc.	24286-1551	ORAL	1 mg in 5 mL	5/15/2025
Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release	ATLANTIC BIOLOGICALS CORP.	17856-0087	ORAL	8 mg in 5 mL	1/10/2023
TUSSICAPS	Physicians Total Care, Inc.	54868-5957	ORAL	8 mg in 1 1	6/8/2012
Advil Allergy and Congestion Relief	Haleon US Holdings LLC	0573-2161	ORAL	4 mg in 1 1	4/9/2025
Allergy Relief	Strategic Sourcing Services LLC	70677-1016	ORAL	4 mg in 1 1	4/9/2025
Sildec PE DM	Rebel Distributors Corp	21695-900	ORAL	4 mg in 5 mL	1/26/2011
Hydrocodone Polistirex and Chlorpheniramine Polisitrex	Atlantic Biologicals Corps	17856-0235	ORAL	8 mg in 5 mL	10/17/2014
Atuss DS Tannate Suspension	Atley Pharmaceuticals, Inc.	59702-800	ORAL	4 mg in 5 mL	2/22/2010

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
AXCEL CHLORPHENIRAMINE TABLETS 4 mg	KOTRA PHARMA (M) SDN BHD	SIN10511P	TABLET	4 mg	12/5/1998
ANTAMIN TABLET 4 mg	XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD	SIN02658P	TABLET	4 mg	4/27/1989
ALLERSIN-F TABLET 4 mg	SUNWARD PHARMACEUTICAL PRIVATE LIMITED	SIN03180P	TABLET	4 mg	6/2/1989
NAZAL SPRAY	SATO PHARMACEUTICAL CO LTD	SIN03722P	SPRAY	500 mg/100 ml	11/6/1989
CHLORPHENIRAMINE TABLET 4 mg	PT. ACTAVIS INDONESIA	SIN02533P	TABLET	4 mg	4/18/1989
CHLORAMINE TABLET 4 mg	BEACONS PHARMACEUTICALS PTE. LTD.	SIN02632P	TABLET	4 mg	4/21/1989
CHLORSEDYL LINCTUS	BEACONS PHARMACEUTICALS PTE LTD	SIN02933P	ELIXIR	4 mg/5 ml	5/22/1989
CHLORPYRIMINE TABLET 4 mg	ATLANTIC LABORATORIES CORPN LTD	SIN03442P	TABLET	4 mg	6/16/1989
ANTAMIN SYRUP 4 mg/5 ml	XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD	SIN05030P	SYRUP	4 mg/5 ml	8/30/1990
CHLORMINE SYRUP 4 mg/5 ml	PT Actavis Indonesia	SIN02527P	SYRUP	4 mg/5ml	4/18/1989

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
FAST FLU TAB	N/A	AMERICAN UNICORN LABORATORIES LIMITED	N/A	N/A	10/18/2002
SURE-RELIEF COLD AND COUGH CAP	N/A	AMERICAN UNICORN LABORATORIES LIMITED	N/A	N/A	6/30/2000
PFC COUGH SYRUP CM FORMULA	N/A	AMERICAN UNICORN LABORATORIES LIMITED	N/A	N/A	7/9/2010
THURAMIN COUGH SYRUP	N/A	AMERICAN UNICORN LABORATORIES LIMITED	N/A	N/A	7/28/2001
CHLORPHENIRAMINE SYR.4MG/5ML	N/A	NEOCHEM PHARMACEUTICAL LABORATORIES LIMITED	N/A	N/A	1/2/1992
CHLORPHENIRAMINE SYRUP 8MG/5ML	N/A	NEOCHEM PHARMACEUTICAL LABORATORIES LIMITED	N/A	N/A	1/2/1992
UNI-CODPLEX SYRUP	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	12/14/1998
NEW-PRITMIN TAB	N/A	AMERICAN UNICORN LABORATORIES LIMITED	N/A	N/A	7/9/2010
RHINO-COMFORT TAB	N/A	AMERICAN UNICORN LABORATORIES LIMITED	N/A	N/A	11/21/2001
X-COLD CAP	N/A	AMERICAN UNICORN LABORATORIES LIMITED	N/A	N/A	6/30/2000

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
AVALLON COLD & FLU DAY + NIGHT RELIEF PE tablet blister pack	300169	NOUMED PHARMACEUTICALS PTY LTD	Medicine	A	3/1/2018
CHEMISTS' OWN CHILDREN'S COLD AND ALLERGY RELIEF LIQUID 6 YEARS TO ADULT oral liquid bottle	71041	Arrotex Pharmaceuticals Pty Ltd	Medicine	A	9/14/1999
TRUST FOR KIDS DECONGESTANT & ANTIHISTAMINE ELIXIR oral liquid - solution bottle	214691	NOUMED PHARMACEUTICALS PTY LTD	Medicine	A	9/17/2013
DEMAZIN KIDS 6+ COLD RELIEF BLUE SYRUP bottle	18813	iNova Pharmaceuticals (Australia) Pty Ltd	Medicine	A	10/8/1991
APOHEALTH COLD RELIEF paracetamol 500 mg and chlorphenamine maleate 2 mg tablet blister pack	254172	Arrotex Pharmaceuticals Pty Ltd	Medicine	A	8/11/2015
APOHEALTH COLD & FLU RELIEF DAY/NIGHT uncoated tablet blister pack	236266	Arrotex Pharmaceuticals Pty Ltd	Medicine	A	4/16/2015
DEMAZIN ORIGINAL COLD + FLU RELIEF DAY + NIGHT tablet blister pack	286002	iNova Pharmaceuticals (Australia) Pty Ltd	Medicine	A	2/22/2017
BLOOMS THE CHEMIST PE DAY + NIGHT COLD & FLU RELIEF tablet blister pack	294345	Arrotex Pharmaceuticals Pty Ltd	Medicine	A	9/26/2017
SUDAFED PE NIGHT tablet blister pack	123048	Johnson & Johnson Pacific Pty Ltd	Medicine	A	10/25/2005
LOGICIN HAY FEVER tablet blister pack	54165	Aspen Pharmacare Australia Pty Ltd	Medicine	A	12/12/1995

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
COLD MEDICATION REGULAR NIGHTTIME TABLETS	cellchem pharmaceuticals inc.	N/A	Tablet - Oral	2 MG	N/A
ADVIL COLD & SINUS PLUS	haleon canada ulc	N/A	Tablet - Oral	2 MG	8/2/2004
ADVIL COLD, SINUS & FLU EXTRA STRENGTH	haleon canada ulc	02471604	Tablet - Oral	4 MG	8/17/2018
VASOFRINIC DH	laboratoires trianon inc.	00472549	Syrup - Oral	2 MG / 5 ML	12/31/1979
FLU MULTI SYMPTOM RELIEF	vita health products inc	02404818	Kit , Tablet - Oral	2 MG	N/A
CHLOR-TRIPOLON DECON EXT STR REPETABS 12	schering-plough canada inc	00576417	Tablet (Extended-Release) - Oral	12 MG	12/31/1983
CORICIDIN COUGH & COLD	Bayer Inc	02245637	Tablet - Oral	4 MG	1/12/2004
BENYLIN D-AH FOR CHILDREN	mcneil consumer healthcare division of johnson & johnson inc	02248334	Syrup - Oral	1 MG / 5 ML	N/A
EXTRA STRENGTH NEOCITRAN FLU NIGHT	novartis consumer health canada inc.	02196174	Package , Powder - Oral	4 MG / PCK	11/11/1997
CHILDREN'S TYLENOL COLD AND COUGH	mcneil consumer healthcare division of johnson & johnson inc	00870455	Tablet - Oral	.5 MG	12/31/1990

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
VINCIGRIP CAPSULAS DURAS	Laboratorios Salvat S.A.	59239	CÁPSULA DURA	Sin Receta	Commercialized

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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