Magnesium sulfate

Generic Name
Magnesium sulfate
Brand Names
Concept Ob, Suflave, Suprep Bowel Prep Kit, Tis-U-sol
Drug Type
Small Molecule
Chemical Formula
MgO4S
CAS Number
7487-88-9
Unique Ingredient Identifier
ML30MJ2U7I
Background

A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)

Indication

Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.

Associated Conditions
Constipation, Convulsions, Hypomagnesemia, Torsades de Pointes, Barium poisoning, Severe Exacerbation of asthma
Associated Therapies
Bowel preparation therapy, Soaking aid for minor sprains and bruises

The Analgesic Efficacy of Magnesium and Ketorolac in Ultrasound Supraclavicular Block

First Posted Date
2020-09-18
Last Posted Date
2022-10-05
Lead Sponsor
Fayoum University Hospital
Target Recruit Count
80
Registration Number
NCT04554862
Locations
🇪🇬

Fayoum University hospital, Madīnat Al Fayyūm, Faiyum Governorate, Egypt

Evaluation of Intravenous Infusion of Labetalol Versus Magnesium Sulfate

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2020-09-07
Last Posted Date
2022-11-15
Lead Sponsor
Zagazig University
Target Recruit Count
60
Registration Number
NCT04539379
Locations
🇪🇬

Faculty of Medicine,Zagazig University, Zagazig, Zagazig, Elsharkia,egypt, Egypt

Opioid-free Analgesia for the Management of Acute Post-operative Pain Following Caesarean Section

First Posted Date
2020-09-04
Last Posted Date
2023-07-20
Lead Sponsor
Olakunle Ifeoluwa Makinde
Target Recruit Count
324
Registration Number
NCT04539249
Locations
🇳🇬

Federal Medical Centre, Yenagoa, Yenagoa, Bayelsa State, Nigeria

Magnesium Sulfate and Neuroendocrine Hormone

First Posted Date
2020-08-17
Last Posted Date
2021-09-24
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
30
Registration Number
NCT04514731
Locations
🇰🇷

Seoul National University Bundang Hospital, Seongnam-si, Korea, Republic of

Does Adding Magnesium Sulphate to Low Dose Rocuronium Affects Depth of Blockade

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2020-08-12
Last Posted Date
2021-03-05
Lead Sponsor
National Cancer Institute, Egypt
Target Recruit Count
60
Registration Number
NCT04510337
Locations
🇪🇬

National Cancer Institute, Cairo, Egypt

Magnesium Sulfate in Combination With Dexmedetomidine As Adjuvants to Levobupivacaine

First Posted Date
2020-08-04
Last Posted Date
2022-04-01
Lead Sponsor
Cairo University
Target Recruit Count
130
Registration Number
NCT04498351
Locations
🇪🇬

Faculty of Medicine, Cairo University., Cairo, Egypt

Intravenous Magnesium in Patients Receiving Cisplatin

Phase 1
Completed
Conditions
Interventions
First Posted Date
2020-07-22
Last Posted Date
2022-01-11
Lead Sponsor
Dana-Farber Cancer Institute
Target Recruit Count
5
Registration Number
NCT04481672
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

Double Dose Magnesium Sulphate in Moderate-severe Asthma in Paediatrics

First Posted Date
2020-07-09
Last Posted Date
2020-07-13
Lead Sponsor
Oman Medical Speciality Board
Target Recruit Count
90
Registration Number
NCT04465175

Magnesium Sulphate to Bupivicaine in Serratus Anterior Plane Block in Modified Radical Mastectomy

First Posted Date
2020-06-12
Last Posted Date
2022-08-02
Lead Sponsor
Alexandria University
Target Recruit Count
80
Registration Number
NCT04429893
Locations
🇪🇬

Rehab Abd Elraof Abd Elaziz, Alexandria, Smouha, Egypt

Intravenous Magnesium Sulphate in Acute Ischemic Stroke

Early Phase 1
Conditions
Interventions
First Posted Date
2020-06-02
Last Posted Date
2020-06-02
Lead Sponsor
Dow University of Health Sciences
Target Recruit Count
44
Registration Number
NCT04412850
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