Does Adding Magnesium Sulphate to Low Dose Rocuronium Affects Depth of Blockade

Not Applicable

Completed

• Conditions: Anesthesia
• Interventions: Drug: standard rocuronium dose; Drug: Magnesium sulfate

• Registration Number: NCT04510337
• Lead Sponsor: National Cancer Institute, Egypt

Brief Summary

This study aim is to compare the effect of magnesium sulphate combined with low dose rocuronium versus standard dose rocuronium

Detailed Description

Comparing the effect of magnesium sulphate combined to low dose rocuronium versus standard dose rocuronium in cancer patients undergoing direct laryngoscopy for laryngeal tumors regarding intubating conditions, intraoperative relaxation, depth of anesthesia and recovery time.

Study Timeline

• Study Start: 2018-04-02
• Study First Submitted: 2020-08-10
• Study First Submitted QC: 2020-08-11
• Study First Posted: 2020-08-12
• Primary Completion: 2021-02-20
• Study Completion: 2021-02-20
• Status Verified: 2021-03
• Last Update Submitted: 2021-03-04
• Last Update Posted: 2021-03-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients with Laryngeal tumors

ASA I-II

Age 30-70 years

Exclusion Criteria

Renal and or hepatic insufficiency

Neuromuscular disease

Large glottic and/or supra-glottic lesions with or without breathing difficulties

Known allergy to any of the used drug

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Standard rocuronium	standard rocuronium dose	patients received rocuronium 0.6mg/kg
Magnesium	Magnesium sulfate	patients received 100 ml saline with 50mg/kg magnesium sulphate infusion over 10 minutes

Primary Outcome Measures

Name	Time	Method
Onset and duration of muscle relaxant	90 minutes	Onset time of muscle relaxant and duration

Secondary Outcome Measures

Name	Time	Method
Degree of muscle relaxation	90 minutes	depth of blockade

Trial Locations

Locations (1)

National Cancer Institute; 🇪🇬 Cairo, Egypt