Effects of Magnesium Sulfate on Onset and Duration of Low Dose Rocuronium in Patients Undergoing Laparoscopic Cholecystectomy
试验速览
- 阶段
- 2 期
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- The time of onset the action of Rocuronium
研究概览
简要总结
This study aims to evaluate effects of magnesium sulfate on onset and duration of low dose rocuronium, intubation condition and surgical condition in patients undergoing laparoscopic cholecystectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists physical status 1 or
- •BMI of 25-34.9 kg/m
- •Patients scheduled for laparoscopic cholecystectomy.
排除标准
- •Severe respiratory or cardiac disease.
- •Hepatic or renal function impairment.
- •Neuromuscular disease.
- •Patients on medications affecting neuromuscular function.
- •Patients with known allergy to the drugs.
研究组 & 干预措施
Standard dose Rocuronium
Pretreatment of saline 100ml then giving Rocuronium 0.6 mg/kg at induction of anesthesia.
干预措施: Saline (Drug)
Standard dose Rocuronium
Pretreatment of saline 100ml then giving Rocuronium 0.6 mg/kg at induction of anesthesia.
干预措施: Standard dose Rocuronium (Drug)
Low dose Rocuronium
Pretreatment of saline 100ml then giving Rocuronium 0.45 mg/kg at induction of anesthesia.
干预措施: Saline (Drug)
Low dose Rocuronium
Pretreatment of saline 100ml then giving Rocuronium 0.45 mg/kg at induction of anesthesia.
干预措施: Low dose Rocuronium (Drug)
Low dose Rocuronium + Magnesium Sulfate
Pretreatment of Magnesium sulfate 30 mg/kg then giving Rocuronium 0.45 mg/kg at induction of anesthesia.
干预措施: Magnesium Sulfate (Drug)
Low dose Rocuronium + Magnesium Sulfate
Pretreatment of Magnesium sulfate 30 mg/kg then giving Rocuronium 0.45 mg/kg at induction of anesthesia.
干预措施: Low dose Rocuronium (Drug)
结局指标
主要结局
The time of onset the action of Rocuronium
时间窗: Time from injection of Rocuronium till T1 suppression more than 95% up to 10 minutes.
by using the TOF watch nerve stimulator
The time at which Maximal suppression
时间窗: Time from the injection of Rocuronium to T1 maximal suppression time (TOF=0) up to an hour.
by using the TOF watch nerve stimulator
Reversal of Rocuronium
时间窗: Time from injection of Rocuronium till reversal of T1 (TOF=25%) around an hour after induction of anesthesia
by using the TOF watch nerve stimulator
次要结局
- Surgical condition(During surgery)
- Intubation condition(Within 10 minutes after induction of anesthesia)