Effects of Magnesium Sulfate on Onset and Duration of Low Dose Rocuronium

Not Applicable

Completed

• Conditions: Observation of Neuromuscular Block; Intubation Condition; Surgical Condition
• Interventions: Drug: saline; Drug: magnesium sulfate 30 mg/kg

• Registration Number: NCT02100293
• Lead Sponsor: Seoul National University Hospital

Brief Summary

This study aims to evaluate effects of magnesium sulfate on onset and duration of low dose rocuronium, intubation condition and surgical condition.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10
• Study First Submitted: 2013-12-11
• Study First Submitted QC: 2014-03-26
• Study First Posted: 2014-03-31
• Primary Completion: 2014-12
• Study Completion: 2014-12
• Status Verified: 2015-07
• Last Update Submitted: 2016-04-15
• Last Update Posted: 2016-04-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

• 18-75 yr American Society of Anesthesiologists physical status 1 or 2, BMI of 20-24.9 kg/m2 scheduled for elective laryngeal microsurgery

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Exclusion Criteria

• severe respiratory or cardiac disease hepatic or renal function impairment neuromuscular disease on medications affecting neuromuscular function with known allergy to the drugs

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
standard dose rocuronium group	saline	pretreatment of saline 100ml and rocuronium 0.6 mg/kg
low dose rocuronium group	saline	pretreatment of saline 100ml and rocuronium 0.45 mg/kg
low dose rocuronium plus magnesium group	magnesium sulfate 30 mg/kg	pretreatment of magnesium sulfate 30 mg/kg and rocuronium 0.45 mg/kg

Primary Outcome Measures

Name	Time	Method
onset time of rocuronium	from injection of rocuronium to T1 suppression more than 95% up to 10 minutes	from injection of rocuronium to T1 suppression more than 95% up to 10 minutes

Secondary Outcome Measures

Name	Time	Method
maximal suppression time and duration of rocuronium	time from the injection of rocuronium to T1 maximal suppression time and reversal of T1 25% up to 1 hours

Trial Locations

Locations (1)

Seoul National Univ. Bundang Hospita; 🇰🇷 Seongnam-si, Gyeonggi-do, Korea, Republic of