Trimethobenzamide
- Generic Name
- Trimethobenzamide
- Brand Names
- Tigan
- Drug Type
- Small Molecule
- Chemical Formula
- C21H28N2O5
- CAS Number
- 138-56-7
- Unique Ingredient Identifier
- W2X096QY97
- Background
Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.
- Indication
For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.
- Associated Conditions
- Nausea, Nausea and vomiting
- Associated Therapies
- -
Apokyn for Motor IMProvement of Morning AKinesia Trial (AM IMPAKT)
- Conditions
- Interventions
- First Posted Date
- 2013-01-17
- Last Posted Date
- 2023-08-14
- Target Recruit Count
- 127
- Registration Number
- NCT01770145
- Locations
- 🇺🇸
Henry Ford West Bloomfield Hospital, Bloomfield Hills, Michigan, United States
🇺🇸University of Texas Health Science Center, Houston, Department of Neurology, Houston, Texas, United States
🇺🇸Center for Neurological Care and Research, San Antonio, Texas, United States
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