奋乃静

概览

Perphenazine is a phenothiazine used to treat schizophrenia as well as nausea and vomiting.

作用机制

Binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre. Perphenazine also binds the alpha andrenergic receptor. This receptor's action is mediated by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

适应症

For use in the management of the manifestations of psychotic disorders and for the control of severe nausea and vomiting in adults.

• Anxiety
• Depression
• Schizophrenia
• Moderate Agitation
• Moderate Anxiety
• Moderate Depressed mood
• Severe Anxiety
• Severe Depressed mood
• Severe Nausea and vomiting
• Severe agitation