Simvastatin
- Generic Name
- Simvastatin
- Brand Names
- Cholib, FloLipid, Simcor, Vytorin, Zocor
- Drug Type
- Small Molecule
- Chemical Formula
- C25H38O5
- CAS Number
- 79902-63-9
- Unique Ingredient Identifier
- AGG2FN16EV
- Background
Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of Aspergillus terreus. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liv...
- Indication
Simvastatin is indicated for the treatment of hyperlipidemia to reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL‑C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C).
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- Associated Conditions
- Cardiovascular Events, Diabetes Mellitus, Heterozygous Familial Hypercholesterolemia (HeFH), High Cholesterol, Homozygous Familial Hypercholesterolaemia (HoFH), Mixed Hyperlipidemia, History of coronary heart disease cardiovascular event, History of stroke or other cerebrovascular disease cardiovascular event
- Associated Therapies
- -
Simvastatin Nasal Rinses for the Treatment of COVID-19 Mediated Dysomsia
- First Posted Date
- 2022-09-15
- Last Posted Date
- 2023-06-12
- Lead Sponsor
- Washington University School of Medicine
- Registration Number
- NCT05542095
Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer
- First Posted Date
- 2022-07-19
- Last Posted Date
- 2023-12-05
- Lead Sponsor
- Emory University
- Target Recruit Count
- 40
- Registration Number
- NCT05464810
- Locations
- 🇺🇸
Emory University Hospital Midtown, Atlanta, Georgia, United States
🇺🇸Emory Saint Joseph's Hospital, Atlanta, Georgia, United States
🇺🇸Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States
Drug-Drug Interaction Study to Investigate Effects of Voclosporin on Pharmacokinetics of Simvastatin
- First Posted Date
- 2022-04-01
- Last Posted Date
- 2022-04-20
- Lead Sponsor
- Aurinia Pharmaceuticals Inc.
- Target Recruit Count
- 24
- Registration Number
- NCT05306379
- Locations
- 🇺🇸
Labcorp Clinical Research Unit, Dallas, Texas, United States
Effect of Statin Therapy on Mortality in Patients With Ventilator Associated Pneumonia
- First Posted Date
- 2022-02-09
- Last Posted Date
- 2022-02-09
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 161
- Registration Number
- NCT05230472
- Locations
- 🇪🇬
Ain Shams University, Cairo, Egypt
Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia
- First Posted Date
- 2021-11-24
- Last Posted Date
- 2022-01-04
- Lead Sponsor
- Hospital General de Mexico
- Target Recruit Count
- 108
- Registration Number
- NCT05133310
- Locations
- 🇲🇽
Hospital General de México "Dr. Eduardo Liceaga", Mexico City, Mexico
Effect of Local Application of Platelet-rich Fibrin Scaffold Loaded With Simvastatin on Peri-implant Bone Changes
- First Posted Date
- 2021-08-17
- Last Posted Date
- 2021-08-17
- Lead Sponsor
- British University In Egypt
- Target Recruit Count
- 8
- Registration Number
- NCT05008068
- Locations
- 🇪🇬
The British University in EGYPT, Cairo, Egypt
Combined Simvastatin and Irinotecan in Treating ES-SCLC Patients Relapsed From 1st Chemotherapy
- First Posted Date
- 2021-08-02
- Last Posted Date
- 2021-08-09
- Lead Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
- Target Recruit Count
- 40
- Registration Number
- NCT04985201
- Locations
- 🇨🇳
Shanghai pulmonary hospital, Tongji University, Shanghai, Shanghai, China
🇨🇳CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, Shanghai, China
The Use of Injectable Plasma Versus the Use of Simvastatin Gel in Surgical Management of Bony Defect in Dentistry
- Conditions
- Interventions
- First Posted Date
- 2021-04-01
- Last Posted Date
- 2021-04-01
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 24
- Registration Number
- NCT04824898
- Locations
- 🇪🇬
Ain Shams University, Cairo, New Cairo, Egypt
Simvastatin Around Immediate Implant
- Conditions
- Interventions
- First Posted Date
- 2021-03-17
- Last Posted Date
- 2021-03-17
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 10
- Registration Number
- NCT04803500
Combined Simvastatin and Albumin Paclitaxel in Treating ES-SCLC Patients Relapsed From 1st Chemotherapy
- First Posted Date
- 2021-01-07
- Last Posted Date
- 2021-07-29
- Lead Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
- Target Recruit Count
- 40
- Registration Number
- NCT04698941
- Locations
- 🇨🇳
CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, Shanghai, China
🇨🇳Shanghai pulmonary hospital, Tongji University, Shanghai, Shanghai, China
Drug Development Updates
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