Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated inflammation and immune responses.
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In the US and Europe, baricitinib is indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more TNF blockers. Baricitinib may be used as monotherapy or in combination with methotrexate or other DMARDs.
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Hamamatsu University School of Medicine University Hospital, Hamamatsu, Shizuoka, Japan
University of Alabama at Birmingham, Birmingham, Alabama, United States
Coastal Clinical Research, Inc, Mobile, Alabama, United States
University of Utah MidValley Dematology, Murray, Utah, United States
First OC Dermatology, Fountain Valley, California, United States
Wallace Medical Group, Inc., Los Angeles, California, United States
Care Access Research-Walnut Creek, Walnut Creek, California, United States
GWU/Medical Faculty Associates, Washington, District of Columbia, United States
Hamzavi Dermatology, Fort Gratiot, Michigan, United States
KA Rudolfstiftung, Wien, Austria
Universitätsklinik Innsbruck, Innsbruck, Tyrol, Austria
Cliniques Universitaires Saint-Luc, Brussels, Belgium
University of Nebraska Medical Center, Omaha, Nebraska, United States
Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
Fremantle Dermatology, Perth, Western Australia, Australia
Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg, Germany
SZTE AOK Borgyogyaszati es Allergologiai Klinika, Szeged, Csongrad, Hungary
Hospital Univ. Dr. Jose Eleuterio Gonzalez, Monterrey, Nuevo León, Mexico
RM Pharma Specialists S.A. de C.V., Distrito Federal, Mexico
National Cheng Kung University Hospital, Tainan City, Taiwan
Oroshaza Varosi Onkormanyzat Korhaza, Oroshaza, Hungary
Nomura Dermatology Clinic, Yokohama-shi, Kanagawa, Japan
Yamate Dermatological Clinic, Shinjuku, Tokyo, Japan
Mayo Clinic, Rochester, Minnesota, United States
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