Desmopressin

Generic Name: Desmopressin

Brand Names: Ddavp, Nocdurna, Octostim

Drug Type: Small Molecule

Chemical Formula: C_₄₆H_₆₄N_₁₄O_₁₂S_₂

CAS Number: 16679-58-6

Unique Ingredient Identifier: ENR1LLB0FP

Background: Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the stimulation of increased plasm...

Indication: 1.治疗中枢性尿崩症，可减少尿量、提高尿渗透压、降低血浆渗透压；

2.用于尿崩症的诊断和鉴别诊断；

3.用于治疗夜间遗尿症（六岁或以上的患者）；

4.部分类型（甲型血友病和Ⅰ型血管性假血友病）的血友病及其他出血性疾病。

Associated Conditions: Bleeding, Hypothalamic Injury-induced Obesity (HIO), Nocturia, Nocturnal Polyuria, Polydipsia, Polyuria, Primary Nocturnal Enuresis

Associated Therapies: -

Clinical Trials

Study of Minirin Melt® in Adult Patients With Nocturia

Terminated

Conditions: Nocturia

First Posted Date: 2017-03-24

Last Posted Date: 2021-02-05

Lead Sponsor: Ferring Pharmaceuticals

Target Recruit Count: 835

Registration Number: NCT03089073

Locations: 🇰🇷
Daegu Fatima Hospital (there may be other sites in this country), Daegu, Korea, Republic of

Intranasal Desmopressin vs IV Ketorolac in Renal Colic Pain Control

Not Applicable

Completed

Conditions: Renal Colic

Interventions: Drug: Ketorolac
Drug: Desmopressin
Drug: Normal Saline

First Posted Date: 2016-10-19

Last Posted Date: 2016-10-19

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Target Recruit Count: 40

Registration Number: NCT02937896

Trial of Desmopressin Orally Disintegrating Tablets (ODT) for Nocturia Due to Nocturnal Polyuria in Japanese Male Subjects

Phase 3

Completed

Conditions: Nocturia

Interventions: Drug: Placebo
Drug: Desmopressin

First Posted Date: 2016-09-19

Last Posted Date: 2019-09-11

Lead Sponsor: Ferring Pharmaceuticals

Target Recruit Count: 342

Registration Number: NCT02904759

Locations: 🇯🇵
Investigational site (there may be other sites in this country), Tokyo, Japan

Trial of Desmopressin Orally Disintegrating Tablets (ODT) for Nocturia Due to Nocturnal Polyuria in Japanese Female Subjects

Phase 3

Completed

Conditions: Nocturia

Interventions: Drug: Placebo
Drug: Desmopressin

First Posted Date: 2016-09-19

Last Posted Date: 2019-09-11

Lead Sponsor: Ferring Pharmaceuticals

Target Recruit Count: 190

Registration Number: NCT02905682

Locations: 🇯🇵
Investigational site (there may be other sites in this country), Tokyo, Japan

Desmopressin as a Therapy for Bedwetting in Children With Sickle Cell Disease

Terminated

Conditions: Nocturnal Enuresis
Anemia, Sickle Cell

Interventions: Drug: Desmopressin

First Posted Date: 2015-12-21

Last Posted Date: 2022-05-31

Lead Sponsor: Montefiore Medical Center

Target Recruit Count: 14

Registration Number: NCT02636387

Locations: 🇺🇸
Children's Hospital at Montefiore, Bronx, New York, United States

Pharmacokinetics and Pharmacodynamics of Desmopressin Oral Lyophilisate Formulation in the Paediatric Population

Phase 4

Completed

Conditions: Monosymptomatic Nocturnal Enuresis

Interventions: Drug: desmopressin

First Posted Date: 2015-10-22

Last Posted Date: 2019-02-06

Lead Sponsor: University Ghent

Target Recruit Count: 25

Registration Number: NCT02584231

Locations: 🇧🇪
Ghent University Hospital - Department of Paediatric Nephrology, Ghent, Belgium

Minirin Versus Oxybutynin for Nocturnal Enuresis in Children

Phase 3

Completed

Conditions: Nocturnal Enuresis

Interventions: Drug: Minirin
Drug: Oxybutynin

First Posted Date: 2015-09-02

Last Posted Date: 2015-09-02

Lead Sponsor: Hormozgan University of Medical Sciences

Target Recruit Count: 66

Registration Number: NCT02538302

Locations: 🇮🇷
Shahid Mohammadi hospital, Bandar Abbas, Hormozgan, Iran, Islamic Republic of

Characterization of Laboratory Response to DDAVP in Adult Hemophilia A Carriers

Phase 1

Completed

Conditions: Hemophilia A

Interventions: Drug: Desmopressin

First Posted Date: 2015-07-22

Last Posted Date: 2018-07-16

Lead Sponsor: Emory University

Target Recruit Count: 2

Registration Number: NCT02506023

Locations: 🇺🇸
Emory University, Atlanta, Georgia, United States
🇺🇸
Children's Hospital of Atlanta Egleston, Atlanta, Georgia, United States

Documentation of the Efficacy of Desmopressin Within the Context of Surgical Procedures

Completed

Conditions: Platelet Dysfunction

Interventions: Drug: desmopressin

First Posted Date: 2015-02-23

Last Posted Date: 2017-06-02

Lead Sponsor: Ferring Pharmaceuticals

Target Recruit Count: 23

Registration Number: NCT02368730

Locations: 🇩🇪
Charité - Universitätsmedizin Berlin (there may be other sites in this country), Berlin, Germany

Comparison Between Desmopressin and Fesoterodine for Treatment of Night Time Voiding in Women Aged 65 and Older

Phase 2

Terminated

Conditions: Nocturia

Interventions: Drug: Desmopressin
Drug: Fesoterodine

First Posted Date: 2014-10-13

Last Posted Date: 2016-11-15

Lead Sponsor: Mount Sinai Hospital, Canada

Target Recruit Count: 4

Registration Number: NCT02262936

Locations: 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada

Drug Development Updates

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