Adding Desmopressin to Tamsulosin for Treatment of BPH
- Conditions
- Nocturnal Polyurea in Patients With BPH
- Interventions
- Drug: Placebo
- Registration Number
- NCT05945420
- Lead Sponsor
- Mansoura University
- Brief Summary
In this study investigators will add desmopressin for treatment of patients with benign prostatic hyperplasia and nocturnal polyurea
- Detailed Description
Investigators will give a group of patients tamsulosin and desmopressin and the other group will take tamsulosin and placepo and compare the outcome regarding symptoms of being prostatic hyperplasia especially nocturia and the effect on nocturnal polyurea in patients
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Male
- Target Recruitment
- 160
Men with BPH Age more than 50years Patients with nocturia (2voids per night or More) Patients with nocturnal polyurea (urine volume More than 33%of urine allover the day) IPSS more than 12 Obstructed flow curve Post voiding residual less than 150
- men with BPH with : Acute urine retention Neurogenic bladder dysfunction Cardiovascular disease Hyponatremia Urethral stricture Bladder calculi Prostate cancer
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo arm Placebo This arm will receive tamsulosin and placepo Desmopressin arm Desmopressin Acetate This arm will receive tamsulosin and desmopressin
- Primary Outcome Measures
Name Time Method Change of symptoms and nocturia disappears or improve Follow up for 6 months Investigators will compare symptoms in the pretreatment period and follow up symptoms following treatment and record the outcome
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Urology and nephrology center
🇪🇬Mansoura, Outside U.S./Canada, Egypt