Outcome of Adding Desmopressin to Tamsulosin for Treatment of Nocturnal Polyurea in Patients With Benign Prostatic Obstruction
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Change of symptoms and nocturia disappears or improve
研究概览
简要总结
In this study investigators will add desmopressin for treatment of patients with benign prostatic hyperplasia and nocturnal polyurea
详细描述
Investigators will give a group of patients tamsulosin and desmopressin and the other group will take tamsulosin and placepo and compare the outcome regarding symptoms of being prostatic hyperplasia especially nocturia and the effect on nocturnal polyurea in patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Men with BPH Age more than 50years Patients with nocturia (2voids per night or More) Patients with nocturnal polyurea (urine volume More than 33%of urine allover the day) IPSS more than 12 Obstructed flow curve Post voiding residual less than 150
排除标准
- •men with BPH with : Acute urine retention Neurogenic bladder dysfunction Cardiovascular disease Hyponatremia Urethral stricture Bladder calculi Prostate cancer
研究组 & 干预措施
Desmopressin arm
This arm will receive tamsulosin and desmopressin
干预措施: Desmopressin Acetate (Drug)
Placebo arm
This arm will receive tamsulosin and placepo
干预措施: Placebo (Drug)
结局指标
主要结局
Change of symptoms and nocturia disappears or improve
时间窗: Follow up for 6 months
Investigators will compare symptoms in the pretreatment period and follow up symptoms following treatment and record the outcome
次要结局
未报告次要终点