Desmopressin
- Generic Name
- Desmopressin
- Brand Names
- Ddavp, Nocdurna, Octostim
- Drug Type
- Small Molecule
- Chemical Formula
- C46H64N14O12S2
- CAS Number
- 16679-58-6
- Unique Ingredient Identifier
- ENR1LLB0FP
- Background
Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the stimulation of increased plasm...
- Indication
1.治疗中枢性尿崩症，可减少尿量、提高尿渗透压、降低血浆渗透压；
2.用于尿崩症的诊断和鉴别诊断；
3.用于治疗夜间遗尿症（六岁或以上的患者）；
4.部分类型（甲型血友病和Ⅰ型血管性假血友病）的血友病及其他出血性疾病。
- Associated Conditions
- Bleeding, Hypothalamic Injury-induced Obesity (HIO), Nocturia, Nocturnal Polyuria, Polydipsia, Polyuria, Primary Nocturnal Enuresis
- Associated Therapies
- -
Desmopressin Melt Therapy in Nocturnal Polyuria Patients: Pharmacodynamic Study
- First Posted Date
- 2011-09-23
- Last Posted Date
- 2022-12-15
- Lead Sponsor
- University Hospital, Ghent
- Target Recruit Count
- 5
- Registration Number
- NCT01439997
- Locations
- 🇧🇪
University Hospital Ghent, Ghent, Belgium
Desmopressin Melt Therapy in Patients With Nocturnal Polyuria: a Pharmacokinetic/Dynamic Study
- First Posted Date
- 2011-09-15
- Last Posted Date
- 2014-12-05
- Lead Sponsor
- University Hospital, Ghent
- Target Recruit Count
- 50
- Registration Number
- NCT01435083
- Locations
- 🇧🇪
University Hospital Ghent, Ghent, Belgium
Investigation of the Superiority Effect of Orally Disintegrating Desmopressin Tablets to Placebo in Terms of Night Voids Reduction in Nocturia Adult Male Patients
- First Posted Date
- 2010-12-17
- Last Posted Date
- 2015-10-15
- Lead Sponsor
- Ferring Pharmaceuticals
- Target Recruit Count
- 395
- Registration Number
- NCT01262456
- Locations
- 🇺🇸
Avail Clinical Research, LLC, DeLand, Florida, United States
🇺🇸FutureCare Studies, Inc., Springfield, Massachusetts, United States
🇺🇸Urology Center Research Institute, Englewood, New Jersey, United States
Investigation of the Superiority Effect of Desmopressin to Placebo in Terms of Night Voids Reduction in Nocturia Adult Female Patients
- First Posted Date
- 2010-10-19
- Last Posted Date
- 2015-10-15
- Lead Sponsor
- Ferring Pharmaceuticals
- Target Recruit Count
- 268
- Registration Number
- NCT01223937
- Locations
- 🇺🇸
Medical Affiliated Research Center Inc., Huntsville, Alabama, United States
🇺🇸Family Medical Center, Foothill Ranch, California, United States
🇺🇸Front Range Clinical Research, Wheatridge, Colorado, United States
Comparative Trial to Investigate the Dose-Response of 4 Different Dose Levels of Minirin Melt and Placebo
- First Posted Date
- 2010-08-19
- Last Posted Date
- 2012-05-25
- Lead Sponsor
- Ferring Pharmaceuticals
- Target Recruit Count
- 116
- Registration Number
- NCT01184859
- Locations
- 🇯🇵
National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
🇯🇵Jyusendo General Hospital, Koriyama, Fukushima, Japan
🇯🇵Kawahara Hinyoukika, Kagoshima, Japan
Study With Two Different Doses of Desmopressin Orally Lyophilisate Tablet With Nocturnal Enuresis
- First Posted Date
- 2010-03-02
- Last Posted Date
- 2011-11-02
- Lead Sponsor
- Ferring Pharmaceuticals
- Target Recruit Count
- 89
- Registration Number
- NCT01078753
- Locations
- 🇯🇵
Kansai Medical University Hirakata Hospital, Hirakata, Osaka, Japan
🇯🇵Tamura Children's Clinic, Mito, Ibaraki, Japan
🇯🇵Shinbo Child Clinic, Yokohama, Kanagawa, Japan
Efficacy and Safety of Desmopressin (Nocturin®) 0.1 mg Tablets in Treatment of Nocturia in Participants With Benign Prostate Syndrome (BPS)
- First Posted Date
- 2009-05-15
- Last Posted Date
- 2011-04-19
- Lead Sponsor
- Ferring Pharmaceuticals
- Target Recruit Count
- 138
- Registration Number
- NCT00902265
- Locations
- 🇩🇪
Investigational Site - Kurfürstendamm 33, Berlin, Germany
🇩🇪Investigational Site - Marburger Straße 12/13, Berlin, Germany
🇩🇪Investigational Site - Mehrower Allee 22, Berlin, Germany
Desmopressin in the Treatment of Mixed Nocturia With Nocturnal Polyuria and Low Nocturnal Bladder Capacity
- First Posted Date
- 2009-05-15
- Last Posted Date
- 2009-05-15
- Lead Sponsor
- Samsung Medical Center
- Target Recruit Count
- 103
- Registration Number
- NCT00902655
- Locations
- 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of
🇰🇷Keimyung University School of Medicine, Daegu, Korea, Republic of
🇰🇷College of Medicine Inha University, Inchon, Korea, Republic of
Desmopressin for Bleeding Related to Low Body Temperature
- Conditions
- Interventions
- First Posted Date
- 2009-05-14
- Last Posted Date
- 2009-05-14
- Lead Sponsor
- The University of Hong Kong
- Target Recruit Count
- 48
- Registration Number
- NCT00902057
- Locations
- 🇨🇳
The University of Hong Kong, Hong Kong, Hong Kong, China
Desmopressin as Treatment for Postoperative Bleeding After Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2009-04-22
- Last Posted Date
- 2015-04-08
- Lead Sponsor
- St. Olavs Hospital
- Target Recruit Count
- 17
- Registration Number
- NCT00885924
- Locations
- 🇳🇴
StOlavs Hopital, Trondheim, Norway
Drug Development Updates
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