Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss . Progesterone is used in various contraceptive preparations to prevent ovulation and fertilization , as well as in other formulations to promote and support pregnancy. Please see Medroxyprogesterone acetate, Megestrol acetate, Dydrogesterone and Hydroxyprogesterone entries for information on various other forms of progesterone.
Pharmaceutical progesterone is made from a plant source as a starting material and is chemically identical to progesterone of human ovarian origin . Progesterone is available in gelatinized capsule form, vaginal gel form, tablet form, vaginal insert form, and injection form, all used for various purposes .
Gelatinized capsules
The gelatinized capsules are indicated for use in the prevention of endometrial hyperplasia in non-hysterectomized postmenopausal women who are receiving conjugated estrogens tablets. They are also indicated for use in secondary amenorrhea .
Vaginal gel
Progesterone gel (8%) is indicated as progesterone supplementation or replacement as part of an Assisted Reproductive Technology (“ART”) treatment for infertile women with progesterone deficiency. The lower concentration progesterone gel (4%) is used in the treatment of secondary amenorrhea, with the use of the 8% concentration if there is no therapeutic response to the 4% gel .
Vaginal insert
This form is indicated to support embryo implantation and early pregnancy by supplementation of corpus luteal function as part of an Assisted Reproductive Technology (ART) treatment program for infertile women .
Injection (intramuscular)
This drug is indicated in amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer .
Tablets, contraceptive
The tablet form of progesterone in contraceptive formulations is indicated for the prevention of pregnancy .
Mount Sinai Hospital, Toronto, Ontario, Canada
St. Michael's Hospital, Toronto, Ontario, Canada
Maple Leaf Medical Clinic, Toronto, Ontario, Canada
University of Padua, Padua, Italy
Obstetrics and Gynecology Department in Mansoura University Hospital, Mansoura, Dakahlia, Egypt
Private practice settings, Mansoura, Dakahlia, Egypt
Haemek Medical Center, Afula, Israel
The Nazareth hospital, Nazareth, Israel
University of North Carolina, Chapel Hill, North Carolina, United States
VA Connecticut Healtcase System, West Haven, Connecticut, United States
St. Mary's Hospital, Montreal, Quebec, Canada
CHU Sainte-Justine, Montreal, Quebec, Canada
MUHC Royal Victoria Hospital, Montreal, Quebec, Canada
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
Obstetrics and Gynecology department, Faculty of Medicine, Chiang Mai University, Muang, Chiang Mai, Thailand
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