MedPath

Oxygen

Generic Name
Oxygen
Brand Names
Alnox, Ez-OX, Heliox, Oxygen, Southern Medical
Drug Type
Small Molecule
Chemical Formula
O2
CAS Number
7782-44-7
Unique Ingredient Identifier
S88TT14065
Background

Oxygen is an element displayed by the symbol O, and atomic number 8. It is an essential element for human survival. Decreased oxygen levels may be treated with medical oxygen therapy. Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing blood flow resistance in the diseased lung, leading to decreased cardiovascular workload in an attempt to oxygenate the lungs. Oxygen therapy is used to treat emphysema, pneumonia, some heart disorders (congestive heart failure), some disorders that cause increased pulmonary artery pressure, and any disease that impairs the body's ability to take up and use gaseous oxygen. Higher level of oxygen than ambient air (hyperoxia) can be introduced under normobaric or hyperbaric conditions.

Indication

Oxygen therapy in clinical settings is used across diverse specialties, including various types of anoxia, hypoxia or dyspnea and any other disease states and conditions that reduce the efficiency of gas exchange and oxygen consumption such as respiratory illnesses, trauma, poisonings and drug overdoses. Oxygen therapy tries to achieve hyperoxia to reduce the extent of hypoxia-induced tissue damage and malfunction.

Associated Conditions
Anemia, Cancer, Hypoxemia, Hypoxia, Migraine, Polycythemia, Pulmonary Hypertension (PH), Respiratory Disorders, Sleep Apnea
Associated Therapies
-

Effect of Using Oxygen on the Diaper Dermatitis in Infants

Not Applicable
Completed
Conditions
Diaper Dermatitis
Diaper Rash
Interventions
First Posted Date
2022-06-22
Last Posted Date
2024-10-18
Lead Sponsor
Istanbul University - Cerrahpasa (IUC)
Target Recruit Count
103
Registration Number
NCT05427760
Locations
🇹🇷

Istanbul University Cerrahpasa, Istanbul, Turkey

Efficacy of Nasal Oxygen Therapy to Reduce Postoperative Complications in Ankle Trauma Surgery in At-risk Patients: a Randomized Pilot Study.

Phase 3
Recruiting
Conditions
Ankle Fractures
Interventions
Other: no oxygen therapy
Drug: Oxygen
First Posted Date
2022-01-11
Last Posted Date
2024-11-28
Lead Sponsor
Nantes University Hospital
Target Recruit Count
200
Registration Number
NCT05185115
Locations
🇫🇷

Dr Gadbed, Nantes, France

Substudy of Protocol 2019-002498-80 - NCT04223050: Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation (O2flow-COPD)

Phase 4
Recruiting
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
First Posted Date
2021-09-22
Last Posted Date
2024-02-29
Lead Sponsor
Mikkel Brabrand
Target Recruit Count
50
Registration Number
NCT05052125
Locations
🇩🇰

Hospital of Southern Denmark, Esbjerg, Esbjerg, Denmark

🇩🇰

Kolding Hospital, Sygehus Lillebælt, Kolding, Denmark

Impact of Oxygen Therapy on Fatigue in Patients With Hypermobile-type Ehlers-Danlos Syndrome

Phase 4
Conditions
Ehlers-Danlos Syndrome
Interventions
Drug: Placebo
Drug: Oxygen
First Posted Date
2021-05-18
Last Posted Date
2022-03-31
Lead Sponsor
Hospital St. Joseph, Marseille, France
Target Recruit Count
82
Registration Number
NCT04890431
Locations
🇫🇷

Hopital Raymond Poincaré, Garches, France

🇫🇷

Hopital Saint Joseph, Marseille, France

🇫🇷

Clinique de la Mitterie, Lille, France

Comparative Study Between Liberal and Conservative Oxygen Therapy in Mechanically Ventilated Intensive Care Patients

Not Applicable
Completed
Conditions
Oxygen Therapy
Interventions
First Posted Date
2021-04-01
Last Posted Date
2024-04-30
Lead Sponsor
Aswan University Hospital
Target Recruit Count
106
Registration Number
NCT04824703
Locations
🇪🇬

Aswan university hospital, Aswan, Egypt

Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery

Not Applicable
Recruiting
Conditions
Coronary Artery Disease
Anesthesia
Interventions
First Posted Date
2021-03-22
Last Posted Date
2024-12-13
Lead Sponsor
Insel Gruppe AG, University Hospital Bern
Target Recruit Count
110
Registration Number
NCT04808401
Locations
🇨🇭

Bern University Hospital, Inselspital, Bern, Switzerland

The Effect of Oxygen Given to Patients in the Postoperative Period on Nausea and Vomiting

Phase 3
Conditions
Oxygen
Postoperative Nausea and Vomiting
Interventions
First Posted Date
2020-10-22
Last Posted Date
2020-10-22
Lead Sponsor
Selcuk University
Target Recruit Count
111
Registration Number
NCT04597723
Locations
🇹🇷

Pınar tunç tuna, Konya, Turkey

High-flow Oxygen Therapy During Exercise in Idiopathic Pulmonary Fibrosis

Not Applicable
Completed
Conditions
Idiopathic Pulmonary Fibrosis
Interventions
First Posted Date
2020-09-25
Last Posted Date
2021-08-13
Lead Sponsor
Parc de Salut Mar
Target Recruit Count
10
Registration Number
NCT04564664
Locations
🇪🇸

Hospital del Mar, Barcelona, Spain

Hyperbaric Versus Normobaric Oxygen Therapy for COVID-19 Patients

Phase 2
Conditions
Covid19
Interventions
First Posted Date
2020-08-05
Last Posted Date
2021-11-01
Lead Sponsor
Ottawa Hospital Research Institute
Target Recruit Count
234
Registration Number
NCT04500626
Locations
🇨🇦

The Ottawa Hospital, Ottawa, Ontario, Canada

🇨🇦

Rouge Valley Hyperbaric Medical Centre, Scarborough, Ontario, Canada

Myocardial Strain Analysis in Anaesthetized Coronary Artery Disease Patients During Hyperoxia and Normoxaemia

Not Applicable
Completed
Conditions
Coronary Artery Disease
Anesthesia
Interventions
First Posted Date
2020-06-11
Last Posted Date
2021-06-09
Lead Sponsor
Insel Gruppe AG, University Hospital Bern
Target Recruit Count
106
Registration Number
NCT04424433
Locations
🇨🇭

Bern University Hospital, Inselspital, Bern, Switzerland

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