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Oxygen

Generic Name
Oxygen
Brand Names
Alnox, Ez-OX, Heliox, Oxygen, Southern Medical
Drug Type
Small Molecule
Chemical Formula
O2
CAS Number
7782-44-7
Unique Ingredient Identifier
S88TT14065
Background

Oxygen is an element displayed by the symbol O, and atomic number 8. It is an essential element for human survival. Decreased oxygen levels may be treated with medical oxygen therapy. Treatment with oxygen serves to increase blood oxygen levels and also exerts a secondary effect of decreasing blood flow resistance in the diseased lung, leading to decreased cardiovascular workload in an attempt to oxygenate the lungs. Oxygen therapy is used to treat emphysema, pneumonia, some heart disorders (congestive heart failure), some disorders that cause increased pulmonary artery pressure, and any disease that impairs the body's ability to take up and use gaseous oxygen. Higher level of oxygen than ambient air (hyperoxia) can be introduced under normobaric or hyperbaric conditions.

Indication

Oxygen therapy in clinical settings is used across diverse specialties, including various types of anoxia, hypoxia or dyspnea and any other disease states and conditions that reduce the efficiency of gas exchange and oxygen consumption such as respiratory illnesses, trauma, poisonings and drug overdoses. Oxygen therapy tries to achieve hyperoxia to reduce the extent of hypoxia-induced tissue damage and malfunction.

Associated Conditions
Anemia, Cancer, Hypoxemia, Hypoxia, Migraine, Polycythemia, Pulmonary Hypertension (PH), Respiratory Disorders, Sleep Apnea

Effect of Using Oxygen on the Diaper Dermatitis in Infants

Not Applicable
Completed
Conditions
Diaper Dermatitis
Diaper Rash
Interventions
First Posted Date
2022-06-22
Last Posted Date
2024-10-18
Lead Sponsor
Istanbul University - Cerrahpasa (IUC)
Target Recruit Count
103
Registration Number
NCT05427760
Locations
🇹🇷

Istanbul University Cerrahpasa, Istanbul, Turkey

Hyperoxia Induced Pulmonary Inflammation and Organ Injury: a Human in Vivo Model

Not Applicable
Recruiting
Conditions
Pulmonary Injury
Acute Lung Injury
Oxygen Toxicity
Interventions
First Posted Date
2022-06-10
Last Posted Date
2024-01-29
Lead Sponsor
Belfast Health and Social Care Trust
Target Recruit Count
53
Registration Number
NCT05414370
Locations
🇬🇧

Belfast Health and Social Care Trus, Belfast, United Kingdom

Hyperbaric Oxygen Therapy for Pyoderma Gangrenosum

Phase 3
Not yet recruiting
Conditions
Pyoderma Gangrenosum
Interventions
Other: Control group
First Posted Date
2022-04-25
Last Posted Date
2022-07-18
Lead Sponsor
Erasmus Medical Center
Target Recruit Count
30
Registration Number
NCT05343754
Locations
🇳🇱

Erasmus MC, Rotterdam, Netherlands

Neuroprotective Effects of Xenon Treatment in Patients with Cerebral Infarction

Phase 3
Completed
Conditions
Ischemic Stroke
Interventions
First Posted Date
2022-04-19
Last Posted Date
2024-10-03
Lead Sponsor
Negovsky Reanimatology Research Institute
Target Recruit Count
40
Registration Number
NCT05335109
Locations
🇷🇺

V.A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation

The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)

Phase 2
Recruiting
Conditions
Obstructive Sleep Apnea
Overlap Syndrome
Chronic Obstructive Pulmonary Disease
Interventions
Device: bi-level positive pressure non invasive ventilation
First Posted Date
2022-02-14
Last Posted Date
2025-04-18
Lead Sponsor
University of California, San Diego
Target Recruit Count
240
Registration Number
NCT05237505
Locations
🇺🇸

UCSD Sleep Research, La Jolla, California, United States

Air as a Placebo: Increasing the Respiratory Performance of People With COPD Through Simple Expectations of Improvement

Not Applicable
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
Other: Compressed Medical Air
First Posted Date
2022-02-01
Last Posted Date
2022-02-01
Lead Sponsor
Fondazione Don Carlo Gnocchi Onlus
Target Recruit Count
102
Registration Number
NCT05218564
Locations
🇮🇹

IRCCS Santa Maria Nascente, Fondazione Don Carlo Gnocchi, Milan, Italy

Efficacy of Nasal Oxygen Therapy to Reduce Postoperative Complications in Ankle Trauma Surgery in At-risk Patients: a Randomized Pilot Study.

Phase 3
Recruiting
Conditions
Ankle Fractures
Interventions
Other: no oxygen therapy
First Posted Date
2022-01-11
Last Posted Date
2024-11-28
Lead Sponsor
Nantes University Hospital
Target Recruit Count
200
Registration Number
NCT05185115
Locations
🇫🇷

Dr Gadbed, Nantes, France

Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms

Phase 2
Active, not recruiting
Conditions
Concussion Post Syndrome
Persistent Post-concussive Syndrome
Interventions
First Posted Date
2021-12-30
Last Posted Date
2025-01-17
Lead Sponsor
Essentia Health
Target Recruit Count
40
Registration Number
NCT05173818
Locations
🇺🇸

Essentia Health, Fargo, North Dakota, United States

Supplemental Oxygen in Hypovolemia

Phase 1
Completed
Conditions
Hypovolemia
Hyperoxia
Interventions
First Posted Date
2021-12-09
Last Posted Date
2022-07-05
Lead Sponsor
Oslo University Hospital
Target Recruit Count
15
Registration Number
NCT05150418
Locations
🇳🇴

Oslo University Hospital, Oslo, Norway

Restrictive Vs. Liberal Oxygen in Trauma

Phase 4
Completed
Conditions
Trauma
Oxygen Toxicity
Wounds and Injuries
Interventions
First Posted Date
2021-12-07
Last Posted Date
2024-10-22
Lead Sponsor
Rigshospitalet, Denmark
Target Recruit Count
1508
Registration Number
NCT05146700
Locations
🇩🇰

Aarhus University Hospital, Aarhus, Denmark

🇩🇰

Odense University Hospital, Odense, Denmark

🇩🇰

Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

and more 2 locations
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