Tramadol

Generic Name: Tramadol

Brand Names: Conzip, Durela, Qdolo, Ralivia, Ryzolt, Seglentis, Tridural, Ultracet, Ultram, Zytram

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₂₅NO_₂

CAS Number: 27203-92-5

Unique Ingredient Identifier: 39J1LGJ30J

Background: Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is consider...

Indication: Tramadol is approved for the management of moderate to severe pain in adults.

Tramadol is also used off-label in the treatment of premature ejaculation.

Associated Conditions: Acute Pain, Premature Ejaculation, Severe Pain, Acute, moderate, severe Pain, Moderate Pain

Associated Therapies: -

Clinical Trials

Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients

Phase 2

Active, not recruiting

Conditions: Head and Neck Squamous Cell Carcinoma

Interventions: Drug: Buprenorphine
Drug: Tramadol
Device: Oral Mucositis (OM) Pain App

First Posted Date: 2021-02-12

Last Posted Date: 2024-05-16

Lead Sponsor: Medical College of Wisconsin

Target Recruit Count: 20

Registration Number: NCT04752384

Locations: 🇺🇸
Froedtert & the Medical College of Wisconsin, Milwaukee, Wisconsin, United States

OTC Naproxen and Acetaminophen Anti-Inflammatory Action in Dental Implant Patients

Phase 4

Completed

Conditions: Osseointegrated Dental Implantation
Pain, Acute

Interventions: Drug: Naproxen
Drug: Acetaminophen
Drug: Tramadol

First Posted Date: 2021-01-05

Last Posted Date: 2024-05-16

Lead Sponsor: Hersh, Elliot V., DMD, MS, PhD

Target Recruit Count: 30

Registration Number: NCT04694300

Locations: 🇺🇸
University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, United States

Continuous Erector Spinae Block for Post Analgesia in Pediatric Patients

Phase 3

Completed

Conditions: Pediatric Cancer

Interventions: Drug: Tramadol hydrochloride
Drug: Bupivacaine Hydrochloride

First Posted Date: 2020-11-03

Last Posted Date: 2023-02-03

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT04613830

Locations: 🇪🇬
South Egypt Cancer instIitute, Assuit, Egypt

Pain Management After Transnasal Transsphenoidal Surgery for Pituitary Adenomas

Not Applicable

Conditions: Pituitary Adenoma
Surgery
Pain

Interventions: Drug: NSAID
Drug: Tramadol

First Posted Date: 2020-11-02

Last Posted Date: 2020-11-03

Lead Sponsor: Peking Union Medical College Hospital

Target Recruit Count: 202

Registration Number: NCT04611685

Locations: 🇨🇳
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Beijing, China

Efficacy and Safety of Tiradentes Association in the Treatment of Acute Pain

Phase 2

Withdrawn

Conditions: Acute Pain

Interventions: Drug: TIRADENTES ASSOCIATION
Drug: TRAMADOL
Drug: DIPYRONE
Other: TIRADENTES ASSOCIATION PLACEBO
Other: DIPYRONE PLACEBO
Other: TRAMADOL PLACEBO

First Posted Date: 2020-10-20

Last Posted Date: 2023-09-08

Lead Sponsor: EMS

Registration Number: NCT04593329

Effect of Tramadol Versus Morphine on PD1 and PD1-ligand in Patients With Chronic Cancer Pain

Phase 2

Conditions: Chronic Pain

Interventions: Drug: Tramadol Hydrochloride

First Posted Date: 2020-10-19

Last Posted Date: 2021-01-14

Lead Sponsor: Assiut University

Target Recruit Count: 15

Registration Number: NCT04589494

Locations: 🇪🇬
Assiut University, Assiut, Egypt

Safety and Efficacy of Tramadol in COVID-19 Egyptian Patients

Phase 1

Conditions: COVID-19

Interventions: Other: Standard care delivered in the isolation hospitals.
Drug: Tramadol

First Posted Date: 2020-07-01

Last Posted Date: 2020-07-02

Lead Sponsor: Tanta University

Target Recruit Count: 100

Registration Number: NCT04454307

Effect of Continue RISS Block in Thoracotomy

Not Applicable

Completed

Conditions: Thoracotomy
Postoperative Pain

Interventions: Other: IV PCA
Drug: Tramadol

First Posted Date: 2020-06-23

Last Posted Date: 2021-04-20

Lead Sponsor: Konya Meram State Hospital

Target Recruit Count: 40

Registration Number: NCT04443556

Locations: 🇹🇷
Konya Education and Training Hospital, Konya, Turkey

Comparison of Tramadol and Dexmedetomidine in the Prevention of Urinary Catheter Discomfort in Urinary Surgery

Not Applicable

Completed

Conditions: Catheter Related Complication

Interventions: Other: control
Drug: Dexmedetomidine
Drug: Tramadol

First Posted Date: 2020-03-18

Last Posted Date: 2021-11-09

Lead Sponsor: Ankara Diskapi Training and Research Hospital

Target Recruit Count: 135

Registration Number: NCT04314050

Locations: 🇹🇷
Diskapi Training and Research Hospital, Ankara, Turkey

Transversus Abdominis Plane Block and Quadratus Lumborum Block in Pediatric Patients

Not Applicable

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Tramadol hydrochloride

First Posted Date: 2019-12-24

Last Posted Date: 2020-01-13

Lead Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Target Recruit Count: 40

Registration Number: NCT04209478

Locations: 🇹🇷
Döndü Genç Moralar, Istanbul, Turkey

Drug Development Updates

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