Tramadol

Generic Name: Tramadol

Brand Names: Conzip, Durela, Qdolo, Ralivia, Ryzolt, Seglentis, Tridural, Ultracet, Ultram, Zytram

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₂₅NO_₂

CAS Number: 27203-92-5

Unique Ingredient Identifier: 39J1LGJ30J

Background: Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is consider...

Indication: Tramadol is approved for the management of moderate to severe pain in adults.

Tramadol is also used off-label in the treatment of premature ejaculation.

Associated Conditions: Acute Pain, Premature Ejaculation, Severe Pain, Acute, moderate, severe Pain, Moderate Pain

Associated Therapies: -

Clinical Trials

Oral Use of Dexketoprofen/Tramadol for Acute Postoperative Pain in Total Hip Replacement With a Direct Anterior Approach.

Phase 2

Completed

Conditions: Postoperative Pain
Pain, Acute

Interventions: Drug: Dexketoprofen/tramadol (27mg/75mg)
Drug: Tramadol hydrochloride
Drug: Ropivacaine Hydrochloride 7.5 MG/ML
Drug: Paracetamol
Drug: Levobupivacaine Hydrochloride

First Posted Date: 2019-11-26

Last Posted Date: 2019-11-26

Lead Sponsor: KAT General Hospital

Target Recruit Count: 226

Registration Number: NCT04178109

Locations: 🇬🇷
Elena Nikolakopoulou, Athens, Kifissia, Greece

Multimodal Analgesia Strategies After Major Shoulder Ambulatory Surgery

Phase 4

Conditions: Tendon Injuries

Interventions: Drug: Tramadol
Drug: Morphine Sulfate
Drug: Nefopam 20 MG/ML
Drug: Oxycodone 20mg

First Posted Date: 2019-10-01

Last Posted Date: 2019-10-01

Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Target Recruit Count: 200

Registration Number: NCT04110665

Locations: 🇫🇷
CHU de Nimes, Nîmes, France

The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty

Not Applicable

Completed

Conditions: Osteo Arthritis Knee

Interventions: Drug: Oxycodone
Drug: Tramadol
Drug: Tylenol
Drug: Meloxicam
Drug: Gabapentin
Drug: Metaxalone
Drug: Esomeprazole 20mg

First Posted Date: 2019-07-01

Last Posted Date: 2019-07-01

Lead Sponsor: Rothman Institute Orthopaedics

Target Recruit Count: 216

Registration Number: NCT04003350

Locations: 🇺🇸
Rothman Institute, Philadelphia, Pennsylvania, United States

Effect of Increased Pain Tolerance on Exercise Performance

Not Applicable

Completed

Conditions: Opioid Use
Exercise

Interventions: Drug: Tramadol
Other: Placebo

First Posted Date: 2019-05-01

Last Posted Date: 2019-05-01

Lead Sponsor: University of Copenhagen

Target Recruit Count: 16

Registration Number: NCT03934411

Locations: 🇩🇰
Department of Nutrition, Exercise and Sports, Copenhagen, Denmark

Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function

Phase 4

Recruiting

Conditions: Osteoarthritis of Multiple Joints of Ankle or Foot
Healthy

Interventions: Drug: Diclofenac
Drug: Paracetamol
Drug: Tramadol

First Posted Date: 2018-12-20

Last Posted Date: 2024-05-17

Lead Sponsor: University of Zurich

Target Recruit Count: 90

Registration Number: NCT03781544

Locations: 🇨🇭
University Heart Center Zurich, Zurich, Switzerland

Drug-Drug Interaction Study of "CG100650" in Healthy Volunteers

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Polmacoxib and Tramadol combination
Drug: Tramadol hydrochloride
Drug: Polmacoxib

First Posted Date: 2018-12-14

Last Posted Date: 2022-05-27

Lead Sponsor: CrystalGenomics, Inc.

Target Recruit Count: 41

Registration Number: NCT03775629

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of

Tramadol Versus Placebo and Morphine in the Management of Post-Operative Pain Abdominoplasty

Phase 3

Active, not recruiting

Conditions: Pain Management

Interventions: Drug: Tramadol
Drug: Morphine
Other: Placebo

First Posted Date: 2018-12-13

Last Posted Date: 2019-05-09

Lead Sponsor: Avenue Therapeutics, Inc.

Target Recruit Count: 360

Registration Number: NCT03774836

Locations: 🇺🇸
Lotus Clinical Research, Pasadena, California, United States
🇺🇸
Hermann Drive Research, Houston, Texas, United States
🇺🇸
Endeavor Clinical Trials, San Antonio, Texas, United States

The Effect of Intrauterine Lidocaine Infusion and Oral Tramadol on Pain During Diagnostic Office Hysteroscopy

Phase 4

Completed

Conditions: Hysteroscopy

Interventions: Drug: Tramadol
Drug: placebo
Drug: Lidocaine

First Posted Date: 2018-10-10

Last Posted Date: 2019-11-18

Lead Sponsor: Cairo University

Target Recruit Count: 156

Registration Number: NCT03701984

Locations: 🇪🇬
faculty of medicine Cairo university, Giza, Egypt

Oral Tramadol Versus Oral Celecoxib for Post-perineal Repair Analgesia

Phase 4

Conditions: Perineal Pain

Interventions: Drug: Celecoxib 200mg
Drug: Tramadol Hydrochloride

First Posted Date: 2018-10-03

Last Posted Date: 2018-10-03

Lead Sponsor: Cairo University

Target Recruit Count: 200

Registration Number: NCT03694873

Quadratus Lumborum Block in Pediatric Patients

Not Applicable

Completed

Conditions: Postoperative Pain

Interventions: Drug: Tramadol Hydrochloride
Drug: Morphine Sulfate

First Posted Date: 2018-10-02

Last Posted Date: 2018-10-04

Lead Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Target Recruit Count: 40

Registration Number: NCT03693222

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

© Copyright 2024. All Rights Reserved by MedPath

Home Terms & Conditions Privacy Policy