MedPath

Cetirizine

Generic Name
Cetirizine
Brand Names
Aller-tec, Aller-tec D, Quzyttir, Reactine, Wal Zyr 24 Hour Allergy, Wal Zyr D, Wal-zyr, Zerviate, Zyrtec, Zyrtec-D
Drug Type
Small Molecule
Chemical Formula
C21H25ClN2O3
CAS Number
83881-51-0
Unique Ingredient Identifier
YO7261ME24

Overview

Cetirizine, also commonly known as Zyrtec, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms , . One of the most common uses for this drug is for a condition called allergic rhinitis. The prevalence of allergic rhinitis in the United States is about 15% according to physician diagnoses, and up to 30%, according to self-reported nasal symptoms. Allergic rhinitis is associated with multiple missed or unproductive days at work and school, problems with sleep, and other difficulties with day to day activities for many individuals . Furthermore, some antihistamine agents that are used to treat this condition cause undesirable, sedating effects . Cetirizine is one of the first second-generation H1 antihistamines (SGAHs) formulated to selectively inhibit the H1 receptor without sedating effects .

Background

Cetirizine, also commonly known as Zyrtec, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms , . One of the most common uses for this drug is for a condition called allergic rhinitis. The prevalence of allergic rhinitis in the United States is about 15% according to physician diagnoses, and up to 30%, according to self-reported nasal symptoms. Allergic rhinitis is associated with multiple missed or unproductive days at work and school, problems with sleep, and other difficulties with day to day activities for many individuals . Furthermore, some antihistamine agents that are used to treat this condition cause undesirable, sedating effects . Cetirizine is one of the first second-generation H1 antihistamines (SGAHs) formulated to selectively inhibit the H1 receptor without sedating effects .

Indication

Seasonal Allergic Rhinitis: Indicated for the relief of symptoms associated with seasonal allergic rhinitis caused by allergens such as ragweed, grass and tree pollens in adults and children 2 years of age and above. Symptoms treated effectively include sneezing, rhinorrhea, nasal pruritus, ocular pruritus, tearing, and redness of the eyes . Perennial allergic rhinitis: This drug is indicated for the relief of symptoms associated with perennial allergic rhinitis due to allergens including dust mites, animal dander, and molds in adults and children 6 months of age and older. Symptoms treated effectively include sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, and tearing . Chronic urticaria: Cetirizine is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 months of age and older. It markedly reduces the occurrence, severity, and duration of hives and significantly reduces pruritus .

Associated Conditions

  • Allergy to Tree Pollen
  • Chronic Idiopathic Urticaria
  • Flu caused by Influenza
  • Perennial Allergic Rhinitis (PAR)
  • Respiratory Allergy
  • Seasonal Allergic Rhinitis

FDA Approved Products

Cetirizine Hydrochloride
Manufacturer:A-S Medication Solutions
Route:ORAL
Strength:1 mg in 1 mL
Approved: 2019/01/21
NDC:50090-3885
Cetirizine Hydrochloride
Manufacturer:PAI Holdings, LLC dba PAI Pharma
Route:ORAL
Strength:1 mg in 1 mL
Approved: 2024/03/20
NDC:0121-0874
Cetirizine Hydrochloride
Manufacturer:Proficient Rx LP
Route:ORAL
Strength:1 mg in 1 mL
Approved: 2020/03/01
NDC:71205-435
Cetirizine Hydrochloride
Manufacturer:Padagis Israel Pharmaceuticals Ltd
Route:ORAL
Strength:1 mg in 1 mL
Approved: 2017/06/14
NDC:45802-626
Cetirizine Hydrochloride
Manufacturer:BAJAJ MEDICAL, LLC
Route:ORAL
Strength:1 mg in 1 mL
Approved: 2023/09/12
NDC:61037-479

Singapore Approved Products

ALNIX TABLET 10mg
Manufacturer:Amherst Laboratories, Inc
Form:TABLET
Strength:10mg
Online:Yes
Approved: 2017/07/14
Approval:SIN15298P
ADEZIO TABLET 10 mg
Manufacturer:XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD
Form:TABLET, FILM COATED
Strength:10 mg
Online:Yes
Approved: 2003/02/07
Approval:SIN12197P
SUNIZINE TABLET 10MG
Manufacturer:Sunward Pharmaceutical Sdn Bhd
Form:TABLET, FILM COATED
Strength:10mg
Online:Yes
Approved: 2012/09/28
Approval:SIN14240P
AGELMIN TABLET 10 mg
Manufacturer:KLEVA S.A.
Form:TABLET, FILM COATED
Strength:10 mg
Online:Yes
Approved: 2003/08/20
Approval:SIN12396P
CERITEC SYRUP 1MG/ML
Manufacturer:Y.S.P. Industries (M) Sdn. Bhd.
Form:SYRUP
Strength:1mg/ml
Online:Yes
Approved: 2016/12/01
Approval:SIN15125P

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