Gentamicin

Generic Name
Gentamicin
Brand Names
Gentak, Pred-G, Valisone-G
Drug Type
Small Molecule
Chemical Formula
C60H123N15O21
CAS Number
1403-66-3
Unique Ingredient Identifier
T6Z9V48IKG
Background

Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from Micromonospora purpurea in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability. Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment ...

Indication

1.本品适用于敏感铜绿假单胞菌、变形杆菌(吲哚阳性和阴性)属、大肠埃希菌、克雷伯菌属、肠杆菌属、沙雷菌属、柠檬酸杆菌属以及葡萄球菌属(不包括耐甲氧西林菌株)所致的严重感染;临床上本品常与β内酰胺类或其他抗菌药物联合应用。本品与青霉素G(或氨苄西林)联合应用治疗肠球菌感染;

2.本品用于铜绿假单胞菌或葡萄球菌属所致的严重中枢神经系统感染(如脑膜炎、脑室炎)时,可同时用本品鞘内注射作为辅助治疗;

3.本品不适用于单纯性尿路感染初治,除非病原菌对其他毒性较低的抗菌药物不敏感,本品对链球菌属中多数菌种(尤其D组)、肺炎链球菌和厌氧菌(如拟杆菌属或梭状芽孢杆菌属)无效;

4.本品口服可用于肠道感染或结肠手术前准备,也可用本品肌注合并克林霉素或甲硝唑以减少结肠手术后感染率。
...

Associated Conditions
Allergic Conjunctivitis (AC), Bacterial Conjunctivitis, Bacterial Infections, Bacterial Keratitis, Bacterial Peritonitis, Bacterial dacryocystitis, Blepharoconjunctivitis, Central Nervous System Infections, Corneal infection, Dermatitis infected, Ecthyma, Eczematous dermatitis infected, Folliculitis, Furunculosis, Gram-negative enteric bacilli neonatal sepsis, Impetigo contagious, Inflammation, Keratoconjunctivitis, Meibomianitis, Meningitis, Bacterial, Ocular Inflammation, Pustular Psoriasis (PP), Pustular acne, Pyoderma Gangrenosum, Seborrheic Dermatitis, Septicemia gram-negative, Skin Infections, Skin and Subcutaneous Tissue Bacterial Infections, Sycosis barbae, Bacterial blepharitis, Bacterial corneal ulcers, Bacterial skin infections, Complicated Respiratory tract infection bacterial, Complicated Urinary Tract Infection caused by susceptible bacteria, Corticosteroid-responsive dermatoses, Ocular bacterial infections, Severe Endocarditis enterococcal, Severe Infection Pseudomonas aeruginosa, Severe Staphylococcal infection
Associated Therapies
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Irrisept vs Traditional Antibiotic Irrigation for Virgin Penile Prosthesis Placement

First Posted Date
2024-07-05
Last Posted Date
2024-08-26
Lead Sponsor
Rush University Medical Center
Target Recruit Count
100
Registration Number
NCT06489431
Locations
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ORal Antibiotics In Acute Mesenteric Ischemia

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2024-04-26
Last Posted Date
2024-04-26
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196
Registration Number
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Locations
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Gastroentérologie-Hépatologie Beaujon, Clichy, France

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Réanimation - Beaujon, Clichy, France

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Chirurgie vasculaire, Paris, France

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Phase 4
Not yet recruiting
Conditions
Interventions
First Posted Date
2024-03-27
Last Posted Date
2024-03-28
Lead Sponsor
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Target Recruit Count
30
Registration Number
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Gentamicin Bladder Instillation on CAUTI

Phase 4
Recruiting
Conditions
Interventions
First Posted Date
2024-03-26
Last Posted Date
2024-03-26
Lead Sponsor
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400
Registration Number
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St. Jpseph's Hospital and Medical Center, Phoenix, Arizona, United States

The Safety and Efficacy of Addition of Gentamicin on Irrigation Fluid in Prevention of Post-Transurethral Resection of the Prostate Infectious Complications.

First Posted Date
2023-12-13
Last Posted Date
2023-12-13
Lead Sponsor
Tanta University
Target Recruit Count
220
Registration Number
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Locations
🇪🇬

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Use of Antibiotic Based Irrigation for Ureteroscopic Treatment of Urolithiasis

Phase 2
Not yet recruiting
Conditions
Interventions
First Posted Date
2023-08-23
Last Posted Date
2024-07-23
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412
Registration Number
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First Posted Date
2023-08-04
Last Posted Date
2023-08-04
Lead Sponsor
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Registration Number
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Westchester Medical Center, Valhalla, New York, United States

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Sinai Health System, Toronto, Canada

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Last Posted Date
2024-12-02
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Target Recruit Count
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Locations
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Atrium Health Cabarrus, Concord, North Carolina, United States

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Pennsylvania State University, Hershey, Pennsylvania, United States

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University of Kentucky, Lexington, Kentucky, United States

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Single Dose Aminoglycosides for Acute Uncomplicated Cystitis in the Emergency Department Setting

First Posted Date
2023-01-27
Last Posted Date
2023-01-27
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Target Recruit Count
160
Registration Number
NCT05702762
Locations
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St. Elizabeth Youngstown Hospital, Youngstown, Ohio, United States

Antibiotic Loaded Cement After TKA

First Posted Date
2022-06-23
Last Posted Date
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Lead Sponsor
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Target Recruit Count
50
Registration Number
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Locations
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Rothman Orthopaedic Institute, Philadelphia, Pennsylvania, United States

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