Metronidazole

Generic Name: Metronidazole

Brand Names: Flagyl, Flagystatin, Likmez, Metrocream, Metrogel, Metrolotion, Nidagel, Noritate, Nuvessa, Pylera, Rosadan, Vandazole

Drug Type: Small Molecule

Chemical Formula: C_₆H_₉N_₃O_₃

CAS Number: 443-48-1

Unique Ingredient Identifier: 140QMO216E

Background: Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections. Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it ...

Indication: Metronidazole is indicated for the treatment of confirmed trichomoniasis caused by Trichomonas vaginalis (except for in the first trimester of pregnancy) and the patient's sexual partners, bacterial vaginosis, certain types of amebiasis, and various anaerobic infections. The above anaerobic infections may occur on the skin and skin structures, the abdomen, t...

Associated Conditions: Abscess Brain, Abscess, Intra-Abdominal, Anaerobic Bacterial Infection, Bacterial Endocarditis, Bacterial Peritonitis, Bacterial Septicemia, Bacterial Vaginosis (BV), Balantidiasis, Bone and Joint Infections, Central Nervous System Bacterial Infections, Empyema, Endometritis, Endomyometritis, Facial Rosacea, Giardiasis, Gynecological Infection, Helicobacter Pylori Infection, Inflammatory Papule, Inflammatory pustules, Liver Abscess, Amebic, Lower respiratory tract infection bacterial, Lung Abscess, Meningitis, Mixed Vaginal Infections, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Periodontitis, Pneumonia, Postoperative Infections, Pouchitis, Skin and skin structure infections, Tetanus, Trichomonas Vaginitis, Tubo-ovarian abscess, Vaginal Candidiasis, Vaginitis Trichomonal, Vulvovaginitis, Acute Intestinal amebiasis, Asymptomatic Trichomoniasis, Entamoeba histolytica, Hepatic abscess, Intra-abdominal bacterial infections, Post-surgical vaginal cuff infection, Refractory Sinusitis, Symptomatic Trichomoniasis

Associated Therapies: -

Clinical Trials

Efficacy of a 14-Day Bismuth-Containing Quadruple Therapy Guided by Drug Susceptibility Testing in Patients with Extremely Refractory Helicobacter Pylori Infection: an Exploratory Study

Not yet recruiting

Conditions: HELICOBACTER PYLORI INFECTIONS

Interventions: Drug: Bismuth
Drug: Vonoprazan
Drug: Amoxicillin
Drug: Rifabutin
Drug: Metronidazole
Drug: Other antibiotics

First Posted Date: 2024-12-12

Last Posted Date: 2024-12-19

Lead Sponsor: Xiuli Zuo

Target Recruit Count: 30

Registration Number: NCT06731023

Locations: 🇨🇳
Qilu Hospital of Shandong University, Jinan, Shandong, China

Study to Assess the Efficacy and Safety of Meropenem and Pralurbactam in CIAI

Phase 3

Not yet recruiting

Conditions: Intra-abdominal Infections

Interventions: Drug: Meropenem and Pralurbactam
Drug: Ceftazidime-avibactam
Drug: Saline
Drug: Metronidazole

First Posted Date: 2024-10-09

Last Posted Date: 2024-10-09

Lead Sponsor: Qilu Pharmaceutical Co., Ltd.

Target Recruit Count: 786

Registration Number: NCT06633718

Locations: 🇨🇳
Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

Phase 2

Not yet recruiting

Conditions: Oral Squamous Cell Carcinoma
Oral Cancer
Head and Neck Cancer
Head and Neck Carcinoma

Interventions: Drug: Metronidazole
Other: Chlorhexidine

First Posted Date: 2024-10-04

Last Posted Date: 2024-12-19

Lead Sponsor: Case Comprehensive Cancer Center

Target Recruit Count: 30

Registration Number: NCT06627270

Locations: 🇺🇸
Case Comprehensive Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio, United States

Phase II Trial Targeting Gut Bacterial Androgen Production to Reverse Therapeutic Resistance to Abiraterone in Patients With Metastatic Prostate Cancer

Phase 2

Not yet recruiting

Conditions: Prostate Cancer (Adenocarcinoma)
Metastatic Prostate Cancer

Interventions: Drug: Abiraterone acetate
Drug: Dexamethasone
Drug: Metronidazole

First Posted Date: 2024-09-27

Last Posted Date: 2024-12-11

Lead Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Target Recruit Count: 58

Registration Number: NCT06616597

Locations: 🇺🇸
Sibley Memorial Hospital, Washington, District of Columbia, United States
🇺🇸
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States

A Phase II Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy

Phase 2

Recruiting

Conditions: Rectal Adenocarcinoma

Interventions: Drug: Metronidazole

First Posted Date: 2024-08-26

Last Posted Date: 2024-08-26

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 60

Registration Number: NCT06569368

Locations: 🇺🇸
MD Anderson Cancer Center, Houston, Texas, United States

ORal Antibiotics In Acute Mesenteric Ischemia

Phase 3

Not yet recruiting

Conditions: Acute Mesenteric Ischemia

Interventions: Drug: Placebo
Drug: Gentamicin
Drug: Metronidazole

First Posted Date: 2024-04-26

Last Posted Date: 2024-04-26

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 196

Registration Number: NCT06387147

Locations: 🇫🇷
Gastroentérologie-Hépatologie Beaujon, Clichy, France
🇫🇷
Réanimation - Beaujon, Clichy, France
🇫🇷
Chirurgie vasculaire, Paris, France

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