Tetracycline

Generic Name: Tetracycline

Brand Names: Pylera, Sumycin

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₄N_₂O_₈

CAS Number: 60-54-8

Unique Ingredient Identifier: F8VB5M810T

Background: Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells.

The FDA withdrew its approval for the use of all liquid oral drug products formulated for pediatric use containing tetracycline in a concentration greater than 25 mg/ml. Other formulations of tetracycline continue to be used.

Indication: Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical organisms (C. pneumoniae, M. pneumoniae, L. pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin.

Associated Conditions: Acinetobacter Infections, Actinomycosis, Anthrax, Bacterial Infections, Bartonellosis, Brucellosis, Campylobacter Infection, Chancroid, Chlamydial Infections, Cholera (Disorder), Clostridium Infections, Conjunctivitis, Inclusion, Cystitis, Endometritis, Entamoebic histolytica infection, Escherichia infections, Granuloma Inguinale, Helicobacter Pylori Infection, Infection, Infection, Bacteroides, Klebsiella Infections, Listeria infection, Lower respiratory tract infection bacterial, Lymphogranuloma Venereum, Necrotizing ulcerative gingivostomatitis, Neisseria Gonorrhoeae Infection, Nephritis, Ornithosis, Plague, Prostatitis, Psittacosis, Q Fever, Relapsing Fever, Rickettsialpox, Rocky Mountain Spotted Fever, Rosacea, Severe Acne, Shigella Infection, Skin Infections caused by Staphylococcus Aureus, Skin and Subcutaneous Tissue Bacterial Infections, Syphilis, Trachoma, Tularemia, Typhus, Upper respiratory tract infection bacterial, Urinary Tract Infection, Yaws, Grade 1, grade 2, grade 3, grade 4 Urinary Tract Infection

Clinical Trials

Tegoprazan-Based Dual Therapy With Amoxicillin vs Tetracycline for H. Pylori Eradication

Not Applicable

Not yet recruiting

Conditions: Helicobacter Pylori Eradication
High-dose Dual Therapy

Interventions: Drug: Tegoprazan
Drug: Amoxicillin 250Mg Cap
Drug: Tetracycline 500 Mg
Drug: Bismuth

First Posted Date: 2025-05-18

Last Posted Date: 2025-05-20

Lead Sponsor: Zhongshan Hospital (Xiamen), Fudan University

Target Recruit Count: 87

Registration Number: NCT06977841

Locations: 🇨🇳
Zhongshan Hospital (Xiamen), Fudan University, Xiamen, Fujian, China

Effect of Tetracycline Socked Pack on Acceleration of Healing During Marsupialization

Not Applicable

Completed

Conditions: Ameloblastoma

Interventions: Drug: Tetracyclin

First Posted Date: 2025-01-06

Last Posted Date: 2025-01-06

Lead Sponsor: Minia University

Target Recruit Count: 14

Registration Number: NCT06759610

Locations: 🇪🇬
Faculty of Dentistry, Minia University, Minya, Egypt

Optimal Duration of Bismuth Quadruple Therapy for Helicobacter Pylori Eradication in Females As Compared with Males

Phase 4

Conditions: Helicobacter Pylori Infection
Sex
Bismuth Quadruple Therapy

Interventions: Drug: Esomeprazole 40mg
Drug: Metronidazole 250 MG
Drug: Tetracycline Pill

First Posted Date: 2024-07-19

Last Posted Date: 2024-11-07

Lead Sponsor: National Cheng-Kung University Hospital

Target Recruit Count: 661

Registration Number: NCT06509139

Locations: 🇨🇳
Helicobacter pylori study group, National Cheng Kung University Hospital, Tainan, Taiwan

Weekly Isotretinoin vs Tetracycline for Moderate Acne

Early Phase 1

Recruiting

Conditions: Acne Vulgaris

Interventions: Drug: Isotretinoin
Drug: Tetracycline

First Posted Date: 2024-01-26

Last Posted Date: 2025-04-08

Lead Sponsor: Medical University of South Carolina

Target Recruit Count: 50

Registration Number: NCT06225570

Locations: 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States

Helicobacter Rescue Therapy With Vonorazon and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy

Phase 4

Recruiting

Conditions: Gastritis Dyspepsia Helicobacter Pylori Infection Gastric Cancer Peptic Ulcer

Interventions: Drug: Bismuth
Drug: Vonoprazan
Drug: amoxicillin
Drug: Esomeprazole
Drug: Tetracycline
Drug: Furazolidone

First Posted Date: 2023-12-13

Last Posted Date: 2024-07-30

Lead Sponsor: Yongquan Shi

Target Recruit Count: 688

Registration Number: NCT06168084

Locations: 🇨🇳
Xijing Hosipital of Digestive Disease, Xi'an, Shanxi, China

Doxycycline for Helicobacter Pylori Rescue Treatment

Phase 4

Recruiting

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Esomeprazole
Drug: Bismuth Potassium Citrate
Drug: Tetracycline
Drug: Doxycycline
Drug: Metronidazole

First Posted Date: 2023-05-25

Last Posted Date: 2024-12-30

Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Target Recruit Count: 368

Registration Number: NCT05874570

Locations: 🇨🇳
Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China

Rescue Therapy for Helicobacter Pylori Infection

Phase 4

Recruiting

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Vonoprazan
Drug: Bismuth Potassium Citrate
Drug: Amoxicillin
Drug: Tetracycline
Drug: Rifabutin
Drug: Metronidazole

First Posted Date: 2023-05-25

Last Posted Date: 2024-12-30

Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Target Recruit Count: 360

Registration Number: NCT05874544

Locations: 🇨🇳
Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China
🇨🇳
Shanghai Songjiang District Central Hospital, Shanghai, Shanghai, China
🇨🇳
The Second Affiliated Hospital of Zhejiang University school of Medicine, Hangzhou, Zhejiang, China

Bismuth Quadruple Therapy in Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies.

Phase 4

Recruiting

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Tetracycline 500mg tid
Drug: Tetracycline 500mg qid

First Posted Date: 2023-04-07

Last Posted Date: 2023-04-07

Lead Sponsor: Shandong University

Target Recruit Count: 260

Registration Number: NCT05802888

Locations: 🇨🇳
Department of Gastroenterology,QiLu Hospital,Shandong University, Jinan, Shandong, China

Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies.

Phase 4

Recruiting

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Tetracyclin

First Posted Date: 2022-06-27

Last Posted Date: 2023-01-31

Lead Sponsor: Shandong University

Target Recruit Count: 407

Registration Number: NCT05432115

Locations: 🇨🇳
Qilu Hospital, Jinan, Shandong, China

Bismuth-containing Quadruple Therapy for Helicobacter Pylori First-line Treatment of Different Tetracycline Doses

Phase 4

Completed

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Amoxicillin
Drug: Tetracycline tid
Drug: Tetracycline qid
Drug: Bismuth Potassium Citrate
Drug: Colloidal Bismuth Pectin
Drug: Esomeprazole 20mg

First Posted Date: 2022-06-24

Last Posted Date: 2024-03-27

Lead Sponsor: Shandong University

Target Recruit Count: 406

Registration Number: NCT05431075

Locations: 🇨🇳
Zhengzhou Central Hospital, Zhengzhou, Henan, China
🇨🇳
Qilu hosipital, Jinan, Shandong, China
🇨🇳
Taierzhuang District People's Hospital, Taierzhuang, Shandong, China

and more 3 locations

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